CD1-Restricted T Cells in Inflammatory Skin Diseases.

Antigen Presentation Antigens, CD1 Autoimmunity Dermatitis / immunology Immune Tolerance T-Lymphocytes

Journal

The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720

Informations de publication

Date de publication:
03 2022
Historique:
received: 04 03 2021
revised: 17 03 2021
accepted: 21 03 2021
pubmed: 17 6 2021
medline: 10 5 2022
entrez: 16 6 2021
Statut: ppublish

Résumé

Autoimmunity results from the breaking of immune tolerance, leading to inflammation and pathology. Although well studied in the conventional T-cell field, the role of nonconventional T cells in autoimmunity is less understood. CD1-restricted T cells recognize lipid antigens rather than peptide antigens and have been implicated in various autoimmune skin conditions, including psoriasis and atopic dermatitis. In this review, we will discuss the self-lipids that CD1-restricted T cells recognize and how these T cells become aberrantly regulated in pathogenic skin conditions.

Identifiants

DOI: 10.1016/j.jid.2021.03.033 PMID: 34130802 PMC: PMC8665943
pubmed: 34130802
pii: S0022-202X(21)01310-5
doi: 10.1016/j.jid.2021.03.033
pmc: PMC8665943
mid: NIHMS1714889
pii:
doi:

Substances chimiques

Antigens, CD1 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

768-773

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI057460
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI145345
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI146072
Pays : United States

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Samantha Genardi (S)

Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

Eva Morgun (E)

Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

Chyung-Ru Wang (CR)

Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. Electronic address: chyung-ru-wang@northwestern.edu.

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Classifications MeSH

questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Immunité cellulaire › Présentation d'antigène › CD1-Restricted T Cells in Inflammatory Skin Diseases.
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Antigènes CD1 › CD1-Restricted T Cells in Inflammatory Skin Diseases.
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Auto-immunité › CD1-Restricted T Cells in Inflammatory Skin Diseases.
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Dermatite › CD1-Restricted T Cells in Inflammatory Skin Diseases.
questionsmedicales.fr › Phénomènes du système immunitaire › Immunomodulation › Tolérance immunitaire › CD1-Restricted T Cells in Inflammatory Skin Diseases.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › CD1-Restricted T Cells in Inflammatory Skin Diseases.