Predicting Long-Term Hepatocellular Carcinoma Response to Transarterial Radioembolization Using Contrast-Enhanced Ultrasound: Initial Experiences.
Contrast-enhanced ultrasound
Fractional vascularity
Hepatocellular carcinoma
Perfusion
Transarterial radioembolization
Yttrium-90
Journal
Ultrasound in medicine & biology
ISSN: 1879-291X
Titre abrégé: Ultrasound Med Biol
Pays: England
ID NLM: 0410553
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
21
10
2020
revised:
26
02
2021
accepted:
06
05
2021
pubmed:
17
6
2021
medline:
15
12
2021
entrez:
16
6
2021
Statut:
ppublish
Résumé
Conventional cross-sectional imaging done shortly after radioembolization of hepatocellular carcinoma (HCC) does not reliably predict long-term response to treatment. This study evaluated whether quantitative contrast-enhanced ultrasound (CEUS) can predict the long-term response of HCC to yttrium-90 (Y-90) treatment. Fifteen patients underwent CEUS at three time points: immediately following treatment and 1 and 2 wk post-treatment. Response 3-6 mo after treatment was categorized on contrast-enhanced magnetic resonance imaging by two experienced radiologists using the Modified Response Evaluation Criteria in Solid Tumors. CEUS data were analyzed by quantifying tumor perfusion and residual fractional vascularity using time-intensity curves. Patients with stable disease on magnetic resonance imaging had significantly greater fractional vascularity 2 wk post-treatment (65.15%) than those with partial or complete response (13.8 ± 9.9%, p = 0.007, and 14.9 ± 15.4%, p = 0.009, respectively). Complete responders had lower tumor vascularity at 2 wk than at post-operative examination (-38.3 ± 15.4%, p = 0.045). Thus, this pilot study suggests CEUS may provide an earlier indication of Y-90 treatment response than cross-sectional imaging.
Identifiants
pubmed: 34130880
pii: S0301-5629(21)00218-0
doi: 10.1016/j.ultrasmedbio.2021.05.006
pmc: PMC8355136
mid: NIHMS1705414
pii:
doi:
Substances chimiques
Contrast Media
0
Yttrium Radioisotopes
0
Yttrium-90
1K8M7UR6O1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2523-2531Subventions
Organisme : NIAMS NIH HHS
ID : F32 AR072491
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA194307
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA238241
Pays : United States
Informations de copyright
Copyright © 2021 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest disclosure The authors declare no competing interests.
Références
Ultrasound Med Biol. 2003 Aug;29(8):1093-103
pubmed: 12946512
Abdom Radiol (NY). 2018 Apr;43(4):762-772
pubmed: 29508011
Hepatology. 2003 Feb;37(2):429-42
pubmed: 12540794
Am J Transplant. 2009 Aug;9(8):1920-8
pubmed: 19552767
Liver Int. 2015 Jun;35(6):1715-21
pubmed: 25443863
Clin Gastroenterol Hepatol. 2013 Oct;11(10):1358-1365.e1
pubmed: 23644386
Abdom Radiol (NY). 2018 Jan;43(1):218-230
pubmed: 28780679
Cochrane Database Syst Rev. 2020 Jan 24;1:CD011313
pubmed: 31978267
Ann Surg. 2011 Apr;253(4):745-58
pubmed: 21475015
Am J Clin Oncol. 1982 Dec;5(6):649-55
pubmed: 7165009
Ultrasound Med Biol. 2012 Jun;38(6):953-61
pubmed: 22475696
Cancer Biol Med. 2018 Aug;15(3):299-310
pubmed: 30197797
Hepatogastroenterology. 2011 Sep-Oct;58(110-111):1431-5
pubmed: 21940325
Ultrasound Med Biol. 2003 Oct;29(10):1421-30
pubmed: 14597339
World J Gastroenterol. 2019 Aug 28;25(32):4614-4628
pubmed: 31528090
Interface Focus. 2011 Aug 6;1(4):520-39
pubmed: 22866229
Science. 2003 May 16;300(5622):1155-9
pubmed: 12750523
Biomed Phys Eng Express. 2018 May;4(3):035039
pubmed: 29887989
Hepatology. 2009 Apr;49(4):1185-93
pubmed: 19133645
Semin Liver Dis. 1999;19(3):329-38
pubmed: 10518312
CA Cancer J Clin. 2020 Jan;70(1):7-30
pubmed: 31912902
Liver Transpl. 2004 Feb;10(2 Suppl 1):S107-10
pubmed: 14762849
Radiology. 2021 Feb;298(2):450-457
pubmed: 33320067
Cancer Lett. 2017 Dec 28;411:100-105
pubmed: 28969964
Gastroenterology. 2018 Oct;155(4):1128-1139.e6
pubmed: 29981779
Korean J Radiol. 2019 Mar;20(3):449-458
pubmed: 30799576
Invest Radiol. 2000 Jan;35(1):72-9
pubmed: 10639038
Adv Exp Med Biol. 2014;772:263-83
pubmed: 24272363
Hepatology. 2013 Dec;58(6):2188-97
pubmed: 23512791
Semin Liver Dis. 2010 Feb;30(1):52-60
pubmed: 20175033
Cancer Treat Rev. 2012 Oct;38(6):641-9
pubmed: 22169503
Eur J Radiol. 2013 May;82(5):e205-11
pubmed: 23273822
Nat Rev Gastroenterol Hepatol. 2019 Oct;16(10):589-604
pubmed: 31439937
J Vasc Interv Radiol. 2007 Jan;18(1 Pt 1):57-65
pubmed: 17296705
J Ultrasound Med. 2015 May;34(5):859-67
pubmed: 25911704
Cardiovasc Intervent Radiol. 2010 Dec;33(6):1143-52
pubmed: 19967371
J Natl Cancer Inst. 2017 Sep 1;109(9):
pubmed: 28376154
J Hepatol. 2013 Nov;59(5):1014-21
pubmed: 23811306
Gastroenterology. 2011 Feb;140(2):497-507.e2
pubmed: 21044630
Abdom Imaging. 2009 Sep-Oct;34(5):566-81
pubmed: 18777189
Radiology. 1998 May;207(2):339-47
pubmed: 9577478