Mortality in Patients With Genetic and Environmental Risk of Liver Disease.
Journal
The American journal of gastroenterology
ISSN: 1572-0241
Titre abrégé: Am J Gastroenterol
Pays: United States
ID NLM: 0421030
Informations de publication
Date de publication:
01 08 2021
01 08 2021
Historique:
received:
25
02
2021
accepted:
06
05
2021
pubmed:
17
6
2021
medline:
26
10
2021
entrez:
16
6
2021
Statut:
ppublish
Résumé
The increasing liver-related mortality calls for hepatic surveillance programs. To design them, factors selectively increasing liver-related vs overall mortality need to be identified. We analyzed mortality data from 467,558 individuals recruited by the community-based UK Biobank. The mean follow-up was 11.4 years. While all assessed genetic factors associated with increased liver-specific mortality, only homozygous TM6SF2 mutation and SERPINA1 mutation conferred elevated overall mortality. Among the environmental factors, obesity and metabolic syndrome disproportionately contributed to liver-related deaths. Our data demonstrate an interplay between genetics and environment and provide a basis for hepatic surveillance programs.
Identifiants
pubmed: 34131090
doi: 10.14309/ajg.0000000000001326
pii: 00000434-202108000-00030
doi:
Substances chimiques
Membrane Proteins
0
SERPINA1 protein, human
0
TM6SF2 protein, human
0
alpha 1-Antitrypsin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1741-1745Subventions
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Informations de copyright
Copyright © 2021 by The American College of Gastroenterology.
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