Identification of H3N2 NA and PB1-F2 genetic variants and their association with disease symptoms during the 2014-15 influenza season.
H3N2
NA
PB1-F2
antigenic drift
human
influenza
symptoms
Journal
Virus evolution
ISSN: 2057-1577
Titre abrégé: Virus Evol
Pays: England
ID NLM: 101664675
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
entrez:
16
6
2021
pubmed:
17
6
2021
medline:
17
6
2021
Statut:
epublish
Résumé
The 2014-15 influenza season saw the emergence of an H3N2 antigenic drift variant that formed the 3C.2a HA clade. Whole viral genomes were sequenced from nasopharyngeal swabs of ninety-four patients with confirmed influenza A virus infection and primary human nasal epithelial cell cultures used to efficiently isolate H3N2 viruses. The isolates were classified by HA clade and the presence of a new set of co-selected mutations in NA (a glycosylation site, NAg+) and PB1-F2 (H75P). The NA and PB1-F2 mutations were present in a subset of clade 3C.2a viruses (NAg+F2P), which dominated during the subsequent influenza seasons. In human nasal epithelial cell cultures, a virus with the novel NAg+F2P genotype replicated less well compared with a virus with the parental genotype. Retrospective analyses of clinical data showed that NAg+F2P genotype viruses were associated with increased cough and shortness of breath in infected patients.
Identifiants
pubmed: 34131512
doi: 10.1093/ve/veab047
pii: veab047
pmc: PMC8197029
doi:
Types de publication
Journal Article
Langues
eng
Pagination
veab047Subventions
Organisme : NIAID NIH HHS
ID : HHSN272201400007C
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007417
Pays : United States
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press.
Références
Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11217-11222
pubmed: 28874549
PLoS One. 2012;7(3):e33166
pubmed: 22412998
FEBS Lett. 2004 Dec 17;578(3):331-6
pubmed: 15589841
Cell Rep. 2015 Jul 7;12(1):1-6
pubmed: 26119736
Crit Care Med. 2010 Apr;38(4 Suppl):e10-20
pubmed: 20048675
Virology. 1984 May;135(1):257-65
pubmed: 6203216
Wkly Epidemiol Rec. 2015 Jun 5;90(23):281-96
pubmed: 26050269
Euro Surveill. 2015 Feb 05;20(5):21025
pubmed: 25677050
Arch Virol. 2016 Jun;161(6):1505-15
pubmed: 26973232
Vaccine. 2017 Oct 27;35(45):6112-6121
pubmed: 28967519
J Virol. 2002 Dec;76(23):12274-80
pubmed: 12414967
Sci Rep. 2015 Oct 16;5:15279
pubmed: 26472175
MMWR Morb Mortal Wkly Rep. 2014 Jun 6;63(22):483-90
pubmed: 24898165
PLoS One. 2011;6(10):e25755
pubmed: 21998692
Vaccine. 2017 Dec 4;35(48 Pt B):6691-6699
pubmed: 29079099
MMWR Morb Mortal Wkly Rep. 2015 Jun 5;64(21):583-90
pubmed: 26042650
Euro Surveill. 2015 Jan 29;20(4):
pubmed: 25655052
Emerg Infect Dis. 2015 Apr;21(4):664-7
pubmed: 25811540
J Virol. 2009 Oct;83(19):10309-13
pubmed: 19605485
Am J Rhinol. 2007 Jan-Feb;21(1):110-6
pubmed: 17283572
Euro Surveill. 2015 May 07;20(18):
pubmed: 25990233
Clin Infect Dis. 2001 Oct 15;33(8):1375-8
pubmed: 11565078
Rev Med Virol. 2003 Mar-Apr;13(2):85-97
pubmed: 12627392
J Virol. 2010 Sep;84(17):8765-76
pubmed: 20573832
CMAJ. 2010 Nov 23;182(17):1851-6
pubmed: 20956500
Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):91-6
pubmed: 21173275
J Virol. 2014 Nov;88(22):13269-83
pubmed: 25210166
J Gen Virol. 2016 Oct;97(10):2516-2527
pubmed: 27558742
J Infect Dis. 2016 Oct 1;214(7):1010-9
pubmed: 27190176
mSphere. 2018 Jan 3;3(1):
pubmed: 29299534
J Virol. 2017 May 12;91(11):
pubmed: 28356532
J Biol Chem. 1995 Jun 16;270(24):14756-61
pubmed: 7782341
J Virol. 2005 Mar;79(6):3595-605
pubmed: 15731254
Eur Respir J. 2019 Aug 15;54(2):
pubmed: 31097520
Nature. 2015 Jul 9;523(7559):217-20
pubmed: 26053121
Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20748-53
pubmed: 22143798
J Virol. 2003 Aug;77(15):8418-25
pubmed: 12857911
Arch Virol. 2016 Sep;161(9):2417-23
pubmed: 27316440
J Virol. 2012 Dec;86(24):13371-83
pubmed: 23015718
J Virol. 2019 Dec 12;94(1):
pubmed: 31597767
J Virol. 2003 Jul;77(13):7214-24
pubmed: 12805420
J Virol. 2015 Oct 14;90(1):222-31
pubmed: 26468540
Clin Infect Dis. 2016 Jul 1;63(1):21-32
pubmed: 27025838
Clin Infect Dis. 2016 Dec 15;63(12):1564-1573
pubmed: 27702768
Vaccine. 2015 Aug 26;33(36):4495-504
pubmed: 26196325
Biochem Biophys Res Commun. 2009 Feb 13;379(3):749-53
pubmed: 19133226
PLoS Pathog. 2020 Jun 29;16(6):e1008411
pubmed: 32598381
J Virol. 2013 Oct;87(19):10539-51
pubmed: 23864615
PLoS Pathog. 2005 Sep;1(1):e4
pubmed: 16201016
Nat Microbiol. 2019 Dec;4(12):2216-2225
pubmed: 31406333
PLoS One. 2012;7(11):e49224
pubmed: 23133677
J Virol. 2011 Dec;85(23):12324-33
pubmed: 21937639
J Biol Chem. 2007 Jan 5;282(1):353-63
pubmed: 17052982
J Virol. 2014 Nov;88(22):13436-46
pubmed: 25210184