The association between prenatal concentrations of polybrominated diphenyl ether and child cognitive and psychomotor function.
Journal
Environmental epidemiology (Philadelphia, Pa.)
ISSN: 2474-7882
Titre abrégé: Environ Epidemiol
Pays: United States
ID NLM: 101719527
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
22
12
2020
accepted:
09
04
2021
entrez:
16
6
2021
pubmed:
17
6
2021
medline:
17
6
2021
Statut:
epublish
Résumé
Previous studies suggest a negative association between prenatal polybrominated diphenyl ethers (PBDEs) exposure and child cognitive and psychomotor development. However, the timing of the relationship between PBDE exposure and neurodevelopment is still unclear. We examined the association between PBDE concentration at two different prenatal times (early and late pregnancy) and cognitive function in children 6-8 years of age. Eight hundred pregnant women were recruited between 2007 and 2009 from Sherbrooke, Canada. Four PBDE congeners (BDE-47, -99, -100, and -153) were measured in maternal plasma samples collected during early pregnancy (12 weeks of gestation) and at delivery. At 6-8 years of age, 355 children completed a series of subtests spanning multiple neuropsychologic domains: verbal and memory skills were measured using the Wechsler Intelligence Scale for Children, Fourth Edition; visuospatial processing using both Wechsler Intelligence Scale for Children, Fourth Edition and Neuropsychological Assessment second edition; and attention was assessed through the Test of Everyday Attention for Children. Additionally, parents completed subtests from the Developmental Coordination Disorder Questionnaire to measure child motor control. We used linear regression and quantile g-computation models to estimate associations of PBDE congener concentrations and psychologic test scores. In our models, no significant associations were detected between PBDE mixture and any of the child psychologic scores. BDE-99 concentration at delivery was nominally associated with higher scores on short-term and working memory while a decrease in spatial perception and reasoning was nominally associated with higher BDE-100 concentration at delivery. Overall, our results did not show a significant association between PBDEs and child cognitive and motor development.
Identifiants
pubmed: 34131617
doi: 10.1097/EE9.0000000000000156
pmc: PMC8196085
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e156Informations de copyright
Copyright © 2021 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The Environmental Epidemiology. All rights reserved.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest with regard to the content of this report.
Références
Environ Res. 2015 Oct;142:104-11
pubmed: 26133807
Neurotoxicology. 2016 May;54:81-88
pubmed: 26955917
Environ Res. 2008 Oct;108(2):158-67
pubmed: 18949835
Environ Int. 2011 Apr;37(3):605-11
pubmed: 21237513
Am J Epidemiol. 2013 Sep 1;178(5):701-13
pubmed: 23924579
Environ Health Perspect. 2020 Apr;128(4):47004
pubmed: 32255670
N Engl J Med. 1999 Aug 19;341(8):549-55
pubmed: 10451459
Neurotoxicol Teratol. 2015 Nov-Dec;52(Pt B):143-50
pubmed: 26344673
J Toxicol Sci. 2012;37(2):223-33
pubmed: 22467012
J Agric Food Chem. 2003 May 7;51(10):3191-5
pubmed: 12720414
Chemosphere. 2014 Jul;106:1-19
pubmed: 24529398
Environ Res. 2017 Feb;153:83-92
pubmed: 27915227
Toxicol Sci. 2006 Jul;92(1):211-8
pubmed: 16611620
Environ Res. 2018 Jul;164:229-240
pubmed: 29501833
Environ Health Perspect. 2003 Jul;111(9):1249-52
pubmed: 12842781
Environ Sci Technol. 2015 Feb 3;49(3):1521-8
pubmed: 25548829
BMC Med Res Methodol. 2009 Jul 28;9:57
pubmed: 19638200
Arch Environ Contam Toxicol. 1989 Jul-Aug;18(4):495-500
pubmed: 2505694
Environ Int. 2018 Sep;118:9-16
pubmed: 29787900
Hum Exp Toxicol. 2014 Feb 24;:
pubmed: 24567298
Environ Health Perspect. 2008 Oct;116(10):1376-82
pubmed: 18941581
Environ Sci Technol. 2005 Feb 15;39(4):925-31
pubmed: 15773463
Child Neuropsychol. 2001 Dec;7(4):251-64
pubmed: 16210214
Environ Health Perspect. 2017 Apr;125(4):746-752
pubmed: 27385187
J Toxicol Environ Health A. 2005 Apr 9;68(7):501-13
pubmed: 15805045
Horm Behav. 2018 May;101:94-104
pubmed: 29137973
Environ Sci Technol. 2005 Sep 15;39(18):7027-35
pubmed: 16201626
Chemosphere. 2002 Feb;46(5):689-96
pubmed: 11999792
Toxicol Sci. 2003 Nov;76(1):112-20
pubmed: 12915714
Epidemiology. 2016 Jan;27(1):91-7
pubmed: 26484424
Crit Rev Toxicol. 2005 Oct-Nov;35(8-9):771-81
pubmed: 16417044
Environ Health Perspect. 2001 Sep;109(9):903-8
pubmed: 11673118
Chemosphere. 2020 Jan;238:124577
pubmed: 31450111
Environ Health. 2016 Apr 12;15:49
pubmed: 27068391
Environ Res. 2016 May;147:556-64
pubmed: 26832761
Neurotoxicol Teratol. 2009 Mar-Apr;31(2):76-84
pubmed: 19068229
Environ Health Perspect. 2014 Aug;122(8):856-62
pubmed: 24870060
Environ Health Perspect. 2010 May;118(5):712-9
pubmed: 20056561
Int J Environ Res Public Health. 2018 Aug 02;15(8):
pubmed: 30072620
Environ Health. 2016 Nov 25;15(1):113
pubmed: 27884139
Acta Biomed. 2008 Dec;79(3):172-83
pubmed: 19260376
Environ Health Perspect. 2013 Feb;121(2):257-62
pubmed: 23154064
Neurotoxicol Teratol. 2015 Nov-Dec;52(Pt B):151-61
pubmed: 26271888
J Dev Behav Pediatr. 2006 Apr;27(2):127-8
pubmed: 16682876
Phys Occup Ther Pediatr. 2009;29(2):182-202
pubmed: 19401931