Impact of pre-eclampsia on renal outcome in sickle cell disease patients.
chronic kidney disease
pre-eclampsia
risk factors
sickle cell disease
sickle cell nephropathy
Journal
British journal of haematology
ISSN: 1365-2141
Titre abrégé: Br J Haematol
Pays: England
ID NLM: 0372544
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
03
03
2021
accepted:
06
04
2021
pubmed:
17
6
2021
medline:
17
12
2021
entrez:
16
6
2021
Statut:
ppublish
Résumé
The long-term consequences of pre-eclampsia (PrE) for renal function have never been determined in patients with sickle cell disease (SCD). Between 2008 and 2015, we screened 306 pregnancies in women with SCD and identified 40 with PrE (13%). The control group consisted of 65 pregnant SCD patients without PrE. In multivariable analysis, PrE events were associated with an increase of 1 log of lactate dehydrogenase level (adjusted odds ratio, aOR = 3·83, P = 0·05), a decrease of 10 g/l of haemoglobin levels (aOR = 2·48, P = 0·006) and one or more vaso-occlusive crisis during pregnancy (aOR = 16·68, P = 0·002). Estimated glomerular filtration rate (eGFR) was similar in the two groups at steady state but was significantly lower in the PrE group after one year of follow-up and at last follow-up (130 vs 148 ml/min/1·73 m
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1053-1062Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2021 British Society for Haematology and John Wiley & Sons Ltd.
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