Estimating serum-ionized magnesium concentration in hemodialysis patients.
calcification
equation
hemodialysis
magnesium
mortality
Journal
Hemodialysis international. International Symposium on Home Hemodialysis
ISSN: 1542-4758
Titre abrégé: Hemodial Int
Pays: Canada
ID NLM: 101093910
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
revised:
17
03
2021
received:
22
10
2020
accepted:
16
05
2021
pubmed:
17
6
2021
medline:
15
12
2021
entrez:
16
6
2021
Statut:
ppublish
Résumé
Cardiovascular mortality is significantly increased in kidney failure with replacement therapy (KFRT) patients, which is partly mediated by enhanced vascular calcification. Magnesium appears to have anticalcifying capabilities, and hypomagnesemia has been associated with increased mortality in KFRT patients. Ionized magnesium represents the biologically and physiologically active form. As serum ionized magnesium (Mg We developed equations to estimate serum Mg The median patient age was 65 years, 67.5% of the patients were male. Median (interquartile range [IQR]) measured Mg Mg
Substances chimiques
Magnesium
I38ZP9992A
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
523-531Subventions
Organisme : NIDDK NIH HHS
ID : T32 DK007777
Pays : United States
Informations de copyright
© 2021 The Authors. Hemodialysis International published by Wiley Periodicals LLC on behalf of International Society for Hemodialysis.
Références
Levey AS, Eckardt KU, Dorman NM, et al. Nomenclature for kidney function and disease: report of a kidney disease: Improving global outcomes (KDIGO) consensus conference. Kidney Int. 2020;97:1117-29.
Goodman WG, Goldin J, Kuizon BD, et al. Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med. 2000;342:1478-83.
Disthabanchong S. Vascular calcification in chronic kidney disease: Pathogenesis and clinical implication. World J Nephrol. 2012;1:43-53.
Henaut L, Massy ZA. Magnesium as a calcification inhibitor. Adv Chronic Kidney Dis. 2018;25:281-90.
Schlieper G, Schurgers L, Brandenburg V, Reutelingsperger C, Floege J. Vascular calcification in chronic kidney disease: An update. Nephrol Dial Transplant. 2016;31:31-9.
Schmaderer C, Braunisch MC, Suttmann Y, et al. Reduced mortality in maintenance haemodialysis patients on high versus low dialysate magnesium: A pilot study. Nutrients. 2017;9:926.
Heaf JG. Chronic kidney disease-mineral bone disorder in the elderly peritoneal dialysis patient. Perit Dial Int. 2015;35:640-4.
Sakaguchi Y, Fujii N, Shoji T, Hayashi T, Rakugi H, Isaka Y. Hypomagnesemia is a significant predictor of cardiovascular and non-cardiovascular mortality in patients undergoing hemodialysis. Kidney Int. 2014;85:174-81.
Reffelmann T, Ittermann T, Dorr M, et al. Low serum magnesium concentrations predict cardiovascular and all-cause mortality. Atherosclerosis. 2011;219:280-4.
Ye H, Cao P, Zhang X, et al. Serum magnesium and cardiovascular mortality in peritoneal dialysis patients: A 5-year prospective cohort study. Br J Nutr. 2018;120:415-23.
Jahnen-Dechent W, Ketteler M. Magnesium basics. Clin Kidney J. 2012;5(Suppl 1):i3-i14.
Workinger JL, Doyle RP, Bortz J. Challenges in the diagnosis of magnesium status. Nutrients. 2018;10:1202.
Sakaguchi Y, Hamano T, Isaka Y. Magnesium in hemodialysis patients: A new understanding of the old problem. Contrib Nephrol. 2018;196:58-63.
Blaine J, Chonchol M, Levi M. Renal control of calcium, phosphate, and magnesium homeostasis. Clin J Am Soc Nephrol. 2015;10:1257-72.
Ben Rayana MC, Burnett RW, Covington AK, et al. IFCC guideline for sampling, measuring and reporting ionized magnesium in plasma. Clin Chem Lab Med. 2008;46:21-6.
Del Giorno R, Riva H, Donato G, Gabutti L. Ionized and total serum magnesium in hemodialysis: predictors and variability. A longitudinal cross-sectional study. Clin Exp Nephrol. 2018;22:620-8.
Sakaguchi Y, Hamano T, Kubota K, et al. Anion gap as a determinant of ionized fraction of divalent cations in hemodialysis patients. Clin J Am Soc Nephrol. 2018;13:274-81.
Nishikawa M, Shimada N, Kanzaki M, et al. The characteristics of patients with hypermagnesemia who underwent emergency hemodialysis. Acute Med Surg. 2018;5:222-9.
Escuela MP, Guerra M, Añón JM, et al. Total and ionized serum magnesium in critically ill patients. Intensive Care Med. 2005;31:151-6.
Salem M, Stacey J, Chemow B. Ionized magnesium values in critically ill patients-A novel ion selective electrode for determining free extracellular magnesium concentrations. Crit Care Med. 1993;21:S256.
Wilkes NJ, Mallett SV, Peachey T, Di Salvo C, Walesby R. Correction of ionized plasma magnesium during cardiopulmonary bypass reduces the risk of postoperative cardiac arrhythmia. Anesth Analg. 2002;95:828-34.
Yokoyama A, Kikuchi K, Kawamura Y. Heart rate variability, arrhythmia and magnesium in hemodialysis patients. Clin Calcium. 2005;15:226-32.
Basten MI. Dissertation: Beobachtungsstudie zur Bedeutung des ionisierten Magnesiums bei chronischer Niereninsuffizienz [Dissertation / PhD Thesis]. Aachen: Rheinisch-Westfälische Technische Hochschule Aachen 2018.
Abudu N, Miller JJ, Elin RJ. The effect of thiocyanate on the Nova ion-selective electrode for magnesium. Clin Chem. 2006;52(S6):A105.
German Medical Association. Guideline of the German Medical Association on Quality Assurance of Medical Laboratory Examinations (RiliBÄK 2014). Dtsch Ärztebl. 2014;111:A1583-618.
Inker LA, Tighiouart H, Coresh J, et al. GFR estimation using beta-trace protein and beta2-microglobulin in CKD. Am J Kidney Dis. 2016;67:40-8.
Shafi T, Michels WM, Levey AS, et al. Estimating residual kidney function in dialysis patients without urine collection. Kidney Int. 2016;89:1099-110.
Inker LA, Schmid CH, Tighiouart H, et al. Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med. 2012;367:20-9.
Steubl D, Fan L, Michels WM, et al. Development and validation of residual kidney function estimating equations in dialysis patients. Kidney Med. 2019;1:104-14.
Levey AS, Stevens LA, Schmid CH, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150:604-12.
Kulesa A, Krzywinski M, Blainey P, Altman N. Sampling distributions and the bootstrap. Nat Methods. 2015;12:477-8.
Kroll MH, Elin RJ. Relationships between magnesium and protein concentrations in serum. Clin Chem. 1985;31:244-6.
Messer AS, Velander WH, Bajaj SP. Contribution of magnesium in binding of factor IXa to the phospholipid surface: Implications for vitamin K-dependent coagulation proteins. J Thromb Haemost. 2009;7:2151-3.
Thomas L. Labor und Diagnose: Indikation und Bewertung von Laborbefunden für die medizinische Diagnostik 2020. Frankfurt, Germany: 2020; https://www.labor-und-diagnose-2020.de/, https://www.clinical-laboratory-diagnostics-2020.com/.
Saha H, Harmoinen A, Pietilä K, Mörsky P, Pasternack A. Measurement of serum ionized versus total levels of magnesium and calcium in hemodialysis patients. Clin Nephrol. 1996;46:326-31.
Dewitte K, Dhondt A, Lameire N, Stöckl D, Thienpont L. The ionized fraction of serum total magnesium in hemodialysis patients: Is it really lower than in healthy subjects? Clin Nephrol. 2002;58:205-10.
Saha HH, Harmoinen AP, Pasternack AI. Measurement of serum ionized magnesium in CAPD patients. Perit Dial Int. 1997;17:347-52.
Cunningham J, Rodríguez M, Messa P. Magnesium in chronic kidney disease stages 3 and 4 and in dialysis patients. Clin Kidney J. 2012;5(Suppl_1):i39-51.
Jain A, Bhayana S, Vlasschaert M, House A. A formula to predict corrected calcium in haemodialysis patients. Nephrol Dial Transplant. 2008;23:2884-8.