Perceived Social Influences on Women's Decisions to use Medications not Studied in Pregnancy. A Qualitative Ethical Analysis of Preexposure Prophylaxis Implementation Research in Kenya.

consent human immunodeficiency virus prevention partners preexposure prophylaxis pregnancy relational autonomy research ethics social influences

Journal

Journal of empirical research on human research ethics : JERHRE
ISSN: 1556-2654
Titre abrégé: J Empir Res Hum Res Ethics
Pays: United States
ID NLM: 101273949

Informations de publication

Date de publication:
07 2021
Historique:
pubmed: 17 6 2021
medline: 12 10 2021
entrez: 16 6 2021
Statut: ppublish

Résumé

Implementation research ethics can be particularly challenging when pregnant women have been excluded from earlier clinical stages of research given greater uncertainty about safety and efficacy in pregnancy. The evaluation of human immunodeficiency virus (HIV) preexposure prophylaxis (PrEP) during pregnancy offered an opportunity to understand important ethical considerations and social influences shaping women's decisions to participate in the evaluation of PrEP and investigational drugs during pregnancy. We conducted interviews with women (

Identifiants

pubmed: 34133231
doi: 10.1177/15562646211012296
pmc: PMC8261769
mid: NIHMS1691179
doi:

Substances chimiques

Anti-HIV Agents 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

225-237

Subventions

Organisme : Wellcome Trust
ID : 200344/Z/15/Z
Pays : United Kingdom
Organisme : NICHD NIH HHS
ID : R00 HD076679
Pays : United States
Organisme : NIMH NIH HHS
ID : R34 MH100940
Pays : United States
Organisme : NICHD NIH HHS
ID : K99 HD076679
Pays : United States
Organisme : Wellcome Trust
ID : 206536/Z/17/Z
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R01 MH101027
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH095507
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI104449
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_16025
Pays : United Kingdom

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Auteurs

Kenneth Ngure (K)

Department of Community Health, 118985Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya.
Department of Global Health, University of Washington, Seattle, WA, USA.

Susan B Trinidad (SB)

Department of Bioethics and Humanities, University of Washington, Seattle, WA, USA.

Kristin Beima-Sofie (K)

Department of Global Health, University of Washington, Seattle, WA, USA.

John Kinuthia (J)

Department of Global Health, University of Washington, Seattle, WA, USA.
Department of Research and Programs, 285569Kenyatta National Hospital, Nairobi, Kenya.

Daniel Matemo (D)

Department of Research and Programs, 285569Kenyatta National Hospital, Nairobi, Kenya.

Grace Kimemia (G)

Population Dynamic and Reproductive Health, 107883African Population and Health Research Center, Nairobi, Kenya.

Anne Njoroge (A)

Department of Global Health, University of Washington, Seattle, WA, USA.
Department of Research and Programs, 285569Kenyatta National Hospital, Nairobi, Kenya.

Lillian Achiro (L)

Center for Microbiology Research, 118982Kenya Medical Research Institute Nairobi, Kenya.

Jillian Pintye (J)

Department of Global Health, University of Washington, Seattle, WA, USA.

Nelly R Mugo (NR)

Department of Global Health, University of Washington, Seattle, WA, USA.
Center for Clinical Research, Kenya Medical Research Institute Nairobi, Kenya.

Elizabeth A Bukusi (EA)

Department of Global Health, University of Washington, Seattle, WA, USA.
Center for Microbiology Research, 118982Kenya Medical Research Institute Nairobi, Kenya.
Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.

Jared M Baeten (JM)

Department of Global Health, University of Washington, Seattle, WA, USA.
Department of Epidemiology, University of Washington, Seattle, WA, USA.
Department of Medicine, University of Washington, Seattle, WA, USA.

Renee Heffron (R)

Department of Global Health, University of Washington, Seattle, WA, USA.
Department of Epidemiology, University of Washington, Seattle, WA, USA.

Grace John-Stewart (G)

Department of Global Health, University of Washington, Seattle, WA, USA.
Department of Epidemiology, University of Washington, Seattle, WA, USA.
Department of Medicine, University of Washington, Seattle, WA, USA.
Department of Pediatrics, University of Washington, Seattle, WA, USA.

Maureen C Kelley (MC)

Wellcome Centre for Ethics & Humanities and Ethox Centre, Nuffield Department of Population Health, 6396University of Oxford, Oxford, UK.

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Classifications MeSH