Ursodeoxycholic acid in the treatment of pregnancy cholestasis: a data-set available for Meta-analyses.
Intrahepatic cholestasis
data set
meta-analysis
outcome
pregnancy
therapy
Journal
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
ISSN: 1476-4954
Titre abrégé: J Matern Fetal Neonatal Med
Pays: England
ID NLM: 101136916
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
pubmed:
18
6
2021
medline:
24
11
2022
entrez:
17
6
2021
Statut:
ppublish
Résumé
The recent literature on intrahepatic cholestasis of pregnancy raises questions on the best management of such a disease. Improved evidence might be achieved by meta-analyses. Providing data for allowing individual patients meta-analyses and aggregate data meta-analyses. Data were collected retrospectively at the Fabia Mater Hospital of Rome (Italy), between 2013 and 2018. Several variables were collected and analyzed according to low-level bile acid (less than 40 μmol/L) and high-level bile acid (at least 40 μmol/L). Eighty-three cases of pregnancy cholestasis, diagnosed according to itching symptoms and excluding bile diseases, were collected and analyzed, both descriptively and inferentially. The analyzed data do not provide significant evidence supporting the use of ursodeoxycholic acid to prevent composite adverse fetal outcomes but they can be included in further meta-analyses.
Sections du résumé
BACKGROUND
UNASSIGNED
The recent literature on intrahepatic cholestasis of pregnancy raises questions on the best management of such a disease. Improved evidence might be achieved by meta-analyses.
AIM
UNASSIGNED
Providing data for allowing individual patients meta-analyses and aggregate data meta-analyses.
METHODS
UNASSIGNED
Data were collected retrospectively at the Fabia Mater Hospital of Rome (Italy), between 2013 and 2018. Several variables were collected and analyzed according to low-level bile acid (less than 40 μmol/L) and high-level bile acid (at least 40 μmol/L). Eighty-three cases of pregnancy cholestasis, diagnosed according to itching symptoms and excluding bile diseases, were collected and analyzed, both descriptively and inferentially.
CONCLUSION
UNASSIGNED
The analyzed data do not provide significant evidence supporting the use of ursodeoxycholic acid to prevent composite adverse fetal outcomes but they can be included in further meta-analyses.
Identifiants
pubmed: 34134582
doi: 10.1080/14767058.2021.1940128
doi:
Substances chimiques
Ursodeoxycholic Acid
724L30Y2QR
Cholagogues and Choleretics
0
Bile Acids and Salts
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM