pH and Proton Sensor GPR65 Determine Susceptibility to Atopic Dermatitis.


Journal

Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R

Informations de publication

Date de publication:
01 07 2021
Historique:
received: 04 12 2020
accepted: 15 04 2021
pubmed: 18 6 2021
medline: 5 1 2022
entrez: 17 6 2021
Statut: ppublish

Résumé

pH sensing by GPR65 regulates various inflammatory conditions, but its role in skin remains unknown. In this study, we performed a phenome-wide association study and report that the T allele of

Identifiants

pubmed: 34135065
pii: jimmunol.2001363
doi: 10.4049/jimmunol.2001363
pmc: PMC8674371
mid: NIHMS1717522
doi:

Substances chimiques

GPR65 protein, mouse 0
Protons 0
Receptors, G-Protein-Coupled 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

101-109

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK117263
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI142784
Pays : United States

Investigateurs

Michelle Agee (M)
Adam Auton (A)
Robert K Bell (RK)
Katarzyna Bryc (K)
Sarah L Elson (SL)
Pierre Fontanillas (P)
Karen E Huber (KE)
Aaron Kleinman (A)
Nadia K Litterman (NK)
Jennifer C McCreight (JC)
Matthew H McIntyre (MH)
Joanna L Mountain (JL)
Elizabeth S Noblin (ES)
Carrie A M Northover (CAM)
Steven J Pitts (SJ)
J Fah Sathirapongsasuti (JF)
Olga V Sazonova (OV)
Janie F Shelton (JF)
Suyash Shringarpure (S)
Chao Tian (C)
Joyce Y Tung (JY)
Vladimir Vacic (V)

Informations de copyright

Copyright © 2021 by The American Association of Immunologists, Inc.

Références

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Auteurs

Liang Xie (L)

Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Hypertension Research Laboratory, School of Biological Sciences, Monash University, Clayton, Victoria, Australia.

Craig I McKenzie (CI)

Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
Department of Allergy, Immunology and Respiratory Medicine, Central Clinical School, Monash University, Melbourne, Victoria, Australia.

Xinyan Qu (X)

School of Pharmaceutical Sciences, Shandong Analysis and Test Center, Qilu University of Technology, Shandong Academy of Sciences, Jinan, China.

Yan Mu (Y)

School of Pharmaceutical Sciences, Shandong Analysis and Test Center, Qilu University of Technology, Shandong Academy of Sciences, Jinan, China.

Quanbo Wang (Q)

School of Pharmaceutical Sciences, Shandong Analysis and Test Center, Qilu University of Technology, Shandong Academy of Sciences, Jinan, China.

Nan Bing (N)

Pfizer, Inc., Cambridge, MA.

Karmella Naidoo (K)

Malaghan Institute of Medical Research, Victoria University of Wellington, Wellington, New Zealand.

Md Jahangir Alam (MJ)

Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.

Di Yu (D)

School of Pharmaceutical Sciences, Shandong Analysis and Test Center, Qilu University of Technology, Shandong Academy of Sciences, Jinan, China.
The University of Queensland Diamantina Institute, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

Fang Gong (F)

Department of Laboratory Medicine, Wuxi Hospital of Integrated Traditional Chinese and Western Medicine, Affiliated Hospital of Jiangnan University, Wuxi, China.

Caroline Ang (C)

Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.

Remy Robert (R)

Department of Physiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.

Francine Z Marques (FZ)

Hypertension Research Laboratory, School of Biological Sciences, Monash University, Clayton, Victoria, Australia.
Heart Failure Research Laboratory, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.

Nicholas Furlotte (N)

23andMe, Inc., Sunnyvale, CA.

David Hinds (D)

23andMe, Inc., Sunnyvale, CA.

Olivier Gasser (O)

Malaghan Institute of Medical Research, Victoria University of Wellington, Wellington, New Zealand.

Ramnik J Xavier (RJ)

Broad Institute, MA.
Center for Computational and Integrative Biology, Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA; and.
Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA.

Charles R Mackay (CR)

Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia; charles.mackay@monash.edu.
School of Pharmaceutical Sciences, Shandong Analysis and Test Center, Qilu University of Technology, Shandong Academy of Sciences, Jinan, China.

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