African swine fever vaccine: Turning a dream into reality.
ASF
control
immunisation
protection
review
vaccine
Journal
Transboundary and emerging diseases
ISSN: 1865-1682
Titre abrégé: Transbound Emerg Dis
Pays: Germany
ID NLM: 101319538
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
revised:
10
06
2021
received:
02
06
2021
accepted:
13
06
2021
pubmed:
18
6
2021
medline:
26
11
2021
entrez:
17
6
2021
Statut:
ppublish
Résumé
African swine fever (ASF) is currently threatening the swine industry at a global level. The disease originated in Africa has spread to Europe, Asia and Oceania, since 2007, reaching a pandemic dimension. Currently, the spread of ASF is unstoppable and that the development of a safe and effective vaccine is urgently required. The objective of this paper is to review the vaccine candidates tested during the 20th and 21st centuries, to identify the strengths and weaknesses of these studies and to highlight what we should learn. Several strategies have been explored to date, some of which have shown positive and negative results. Inactivated preparations and subunit vaccines are not a viable option. The most promising strategy would appear to be live attenuated vaccines, because these vaccine candidates are able to induce variable percentages of protection against certain homologous and heterologous virus isolates. The number of studies on live attenuated vaccine candidates has steadily increased in the 21st century thanks to advances in molecular biology and an in-depth knowledge of ASF virus, which have allowed the development of vaccines based on deletion mutants. The deletion of virulence-related genes has proved to be a useful tool for attenuation, although attenuation does not always mean protection and even less, cross protection. Therefore, ASF vaccine development has proved to be one of the top priorities in ASF research. Efforts are still being made to fill the gaps in the knowledge regarding immune response, safety and cross protection, and these efforts will hopefully help to find a safe and effective vaccine that could be commercialised soon, thus making it possible to turn a dream into reality.
Substances chimiques
Vaccines, Attenuated
0
Viral Proteins
0
Viral Vaccines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2657-2668Subventions
Organisme : European Project H2020 VACDIVA - 'A Safe DIVA vaccine for African Swine Fever control and eradication'
ID : 862874
Informations de copyright
© 2021 The Authors. Transboundary and Emerging Diseases published by Wiley-VCH GmbH.
Références
Abrams, C. C., Goatley, L., Fishbourne, E., Chapman, D., Cooke, L., Oura, C. A., Netherton, C. L., Takamatsu, H. H., & Dixon, L. K. (2013). Deletion of virulence associated genes from attenuated African swine fever virus isolate OUR T88/3 decreases its ability to protect against challenge with virulent virus. Virology, 443(1), 99-105. https://doi.org/10.1016/j.virol.2013.04.028
Achenbach, J. E., Gallardo, C., Nieto-Pelegrín, E., Rivera-Arroyo, B., Degefa-Negi, T., Arias, M., Jenberie, S., Mulisa, D. D., Gizaw, D., Gelaye, E., Chibssa, T. R., Belaye, A., Loitsch, A., Forsa, M., Yami, M., Diallo, A., Soler, A., Lamien, C. E., & Sánchez-Vizcaíno, J. M. (2017). Identification of a new genotype of African swine fever virus in domestic pigs from Ethiopia. Transboundary and Emerging Diseases, 64(5), 1393-1404. https://doi.org/10.1111/tbed.12511
Alejo, A., Matamoros, T., Guerra, M., & Andrés, G. (2018). A proteomic atlas of the African swine fever virus particle. Journal of Virology, 92(23), e01293-18. https://doi.org/10.1128/jvi.01293-18
Andrés, G., Charro, D., Matamoros, T., Dillard, R. S., & Abrescia, N. G. A. (2020). The cryo-EM structure of African swine fever virus unravels a unique architecture comprising two icosahedral protein capsids and two lipoprotein membranes. Journal of Biological Chemistry, 295(1), 1-12. https://doi.org/10.1074/jbc.AC119.011196
Argilaguet, J. M., Pérez-Martín, E., Gallardo, C., Salguero, F. J., Borrego, B., Lacasta, A., Accensi, F., Díaz, I., Nofrarías, M., Pujols, J., Blanco, E., Pérez-Filgueira, M., Escribano, J. M., & Rodríguez, F. (2011). Enhancing DNA immunization by targeting ASFV antigens to sla-ii bearing cells. Vaccine, 29(33), 5379-5385. https://doi.org/10.1016/j.vaccine.2011.05.084
Argilaguet, J. M., Pérez-Martín, E., López, S., Goethe, M., Escribano, J. M., Giesow, K., Keil, G. M., & Rodríguez, F. (2013). BacMam immunization partially protects pigs against sublethal challenge with African swine fever virus. Antiviral Research, 98(1), 61-65. https://doi.org/10.1016/j.antiviral.2013.02.005
Argilaguet, J. M., Pérez-Martín, E., Nofrarías, M., Gallardo, C., Accensi, F., Lacasta, A., Mora, M., Ballester, M., Galindo-Cardiel, I., López-Soria, S., Escribano, J. M., Reche, P. A., & Rodríguez, F. (2012). DNA vaccination partially protects against African swine fever virus lethal challenge in the absence of antibodies. PLoS ONE, 7(9), e40942. https://doi.org/10.1371/journal.pone.0040942
Arias, M., de la Torre, A., Dixon, L., Gallardo, C., Jori, F., Laddomada, A., Martins, C., Parkhouse, R. M., Revilla, Y., Jose-Manuel Rodriguez, F., & Sanchez-Vizcaino, J. M. (2017). Approaches and perspectives for development of African swine fever virus vaccines. Vaccines, 5(4), 35. https://doi.org/10.3390/vaccines5040035
Arias, M., Jurado, C., Gallardo, C., Fernández-Pinero, J., & Sánchez-Vizcaíno, J. M. (2018). Gaps in African swine fever: Analysis and priorities. Transboundary and Emerging Diseases, 63(1), 235-347. https://doi.org/10.1111/tbed.12695
Arias, M., Sánchez-Vizcaíno, J. M., Morilla, A., Yoon, K.J., & Zimmerman, J. J. (2002). African swine fever eradication: The Spanish model. In A. Morilla, K. J. Yoon, & J. J. Zimmerman (Eds.), Trends in emerging viral infections of swine (pp. 133-139). Iowa State Press. https://doi.org/10.1002/9780470376812.ch4c
Barasona, J. A., Gallardo, C., Cadenas-Fernández, E., Jurado, C., Rivera, B., Rodríguez-Bertos, A., Arias, M., & Sánchez-Vizcaíno, J. M. (2019). First oral vaccination of Eurasian wild boar against African swine fever virus genotype II. Frontiers in Veterinary Science, 6, 137. https://doi.org/10.3389/fvets.2019.00137
Barderas, M. G., Rodríguez, F., Gómez-Puertas, P., Avilés, M., Beitia, F., Alonso, C., & Escribano, J. M. (2001). Antigenic and immunogenic properties of a chimera of two immunodominant African swine fever virus proteins. Archives of Virology, 146(9), 1681-1691. https://doi.org/10.1007/s007050170056
Bastos, A. D. S., Penrith, M. L., Crucière, C., Edrich, J. L., Hutchings, G., Roger, F., Couacy-Hymann, E., & Thomson, G. R. (2003). Genotyping field strains of African swine fever virus by partial p72 gene characterisation. Archives of Virology, 148(4), 693-706. https://doi.org/10.1007/s00705-002-0946-8
Beltrán-Alcrudo, D., Lubroth, J., Depner, K., Rocque, S. D. La, Beltran-Alcrudo, D., Lubroth, J., … De La Rocque, S. (2008). African swine fever in the Caucasus. FAO, Empres Watch.
Blome, S., Gabriel, C., & Beer, M. (2014). Modern adjuvants do not enhance the efficacy of an inactivated African swine fever virus vaccine preparation. Vaccine, 32(31), 3879-3882. https://doi.org/10.1016/j.vaccine.2014.05.051
Boinas, F. S., Hutchings, G. H., Dixon, L. K., & Wilkinson, P. J. (2004). Characterization of pathogenic and non-pathogenic African swine fever virus isolates from Ornithodoros erraticus inhabiting pig premises in Portugal. Journal of General Virology, 85(Pt8), 2177-2187. https://doi.org/10.1099/vir.0.80058-0
Bommeli, W., Kihm, U., & Ehrensperger, F. (1981). Preliminary study on immunization of pigs against African swine fever. In Proceedings of the CEC/FAO Research Seminar Held in Sassari, Sardinia, Italy, 23-25 September 1981. https://agris.fao.org/agris-search/search.do?recordID=XF8224647
Borca, M. V., O'Donnell, V., Holinka, L. G., Risatti, G. R., Ramirez-Medina, E., Vuono, E. A., Shi, J., Pruitt, S., Rai, A., Silva, E., Velazquez-Salinas, L., & Gladue, D. P. (2020). Deletion of CD2-like gene from the genome of African swine fever virus strain Georgia does not attenuate virulence in swine. Scientific Reports, 10(1), 494. https://doi.org/10.1038/s41598-020-57455-3
Borca, M. V., Ramirez-Medina, E., Silva, E., Vuono, E., Rai, A., Pruitt, S., Holinka, L. G., Velazquez-Salinas, L., Zhu, J., & Gladue, D. P. (2020). Development of a highly effective African swine fever virus vaccine by deletion of the I177L gene results in sterile immunity against the current epidemic Eurasia strain. Journal of Virology, 94(7), e02017-19. https://doi.org/10.1128/jvi.02017-19
Brown, V. R., Miller, R. S., McKee, S. C., Ernst, K. H., Didero, N. M., Maison, R. M., Grady, M. J., & Shwiff, S. A. (2021). Risks of introduction and economic consequences associated with African swine fever, classical swine fever and foot-and-mouth disease: A review of the literature. Transboundary and Emerging Diseases, 68(4), 1910-1065. https://doi.org/10.1111/tbed.13919
Burmakina, G., Malogolovkin, A., Tulman, E. R., Zsak, L., Delhon, G., Diel, D. G., Shobogorov, N. M., Morgunov, Y. P., Morgunov, S. Y., Kutish, G. F., Kolbasov, D., & Rock, D. L. (2016). African swine fever virus serotype-specific proteins are significant protective antigens for African swine fever. Journal of General Virology, 97(7), 1670-1675. https://doi.org/10.1099/jgv.0.000490
Cadenas-Fernández, E., Sánchez-Vizcaíno, J. M., Kosowska, A., Rivera, B., Mayoral-Alegre, F., Rodríguez-Bertos, A., Yao, J., Bray, J., Lokhandwala, S., Mwangi, W., & Barasona, J. A. (2020). Adenovirus-vectored African swine fever virus antigens cocktail is not protective against virulent Arm07 isolate in Eurasian wild boar. Pathogens, 28(9), 171. https://doi.org/10.3390/pathogens9030171
Cadenas-Fernández, E., Sánchez-Vizcaíno, J. M., van den Born, E., Kosowska, A., van Kilsdonk, E., Fernández-Pacheco, P., Gallardo, C., Arias, M., & Barasona, J. A. (2021). High doses of inactivated African swine fever virus are safe, but do not confer protection against a virulent challenge. Vaccines, 9(3), 242. https://doi.org/10.3390/vaccines9030242
Carlson, J., O'Donnell, V., Alfano, M., Salinas, L. V., Holinka, L. G., Krug, P. W., Gladue, D. P., Higgs, S., & Borca, M. V. (2016). Association of the host immune response with protection using a live attenuated African swine fever virus model. Viruses, 8(10), 291. https://doi.org/10.3390/v8100291
Carrascosa, A. L., Sastre, I., & Viñuela, E. (1995). Production and purification of recombinant African swine fever virus attachment protein p12. Journal of Biotechnology, 40(2), 73-86. https://doi.org/10.1016/0168-1656(95)00035-O
Chen, W., Zhao, D., He, X., Liu, R., Wang, Z., Zhang, X., Li, F., Shan, D., Chen, H., Zhang, J., Wang, L., Wen, Z., Wang, X., Guan, Y., Liu, J., & Bu, Z. (2020). A seven-gene-deleted African swine fever virus is safe and effective as a live attenuated vaccine in pigs. Science China Life Sciences, 63(5), 623-634. https://doi.org/10.1007/s11427-020-1657-9
Coggins, L., Moulton, J. E., & Colgrove, G. S. (1968). Studies with hinde attenuated African swine fever virus. Cornell Veterinarian, 48(4), 525-540.
De Kock, G., Robinson, E. M., & Keppel, J. J. G. (1940). Swine fever in South Africa (East African swine fever). Onderstepoort Journal of Veterinary Science and Animal Industry, 14, 31-39. https://repository.up.ac.za/handle/2263/59428
Detray, D. E. (1957). African swine fever in wart hogs (Phacochoerus aethiopicus). Journal of the American Veterinary Medical Association, 18, 811-816.
Dixon, L. K., Chapman, D. A. G., Netherton, C. L., & Upton, C. (2013). African swine fever virus replication and genomics. Virus Research, 173(1), 3-14. https://doi.org/10.1016/j.virusres.2012.10.020
Dixon, L. K., Islam, M., Nash, R., & Reis, A. L. (2019). African swine fever virus evasion of host defences. Virus Research, 266, 25-33. https://doi.org/10.1016/j.virusres.2019.04.002
Dixon, L. K., Sun, H., & Roberts, H. (2019). African swine fever. Antiviral Research, 165, 34-41. https://doi.org/10.1016/j.antiviral.2019.02.018
Escribano, J. M., Galindo, I., & Alonso, C. (2013). Antibody-mediated neutralization of African swine fever virus: Myths and facts. Virus Research, 173(1), 101-109. https://doi.org/10.1016/j.virusres.2012.10.012
Food and Agriculture Organization of the United Nations (FAO). (2021). ASF situation update - African Swine Fever (ASF) - FAO Emergency Prevention System for Animal Health (EMPRES-AH). http://www.fao.org/ag/againfo/programmes/en/empres/ASF/situation_update.html
Forman, A. J., Wardley, R. C., & Wilkinson, P. J. (1982). The immunological response of pigs and Guinea pigs to antigens of African swine fever virus. Archives of Virology, 74(2-3), 91-100. https://doi.org/10.1007/BF01314703
Gallardo, C., Sánchez, E. G., Pérez-Núñez, D., Nogal, M., de León, P., Carrascosa, Á. L., Nieto, R., Soler, A., Arias, L. M., & Revilla, Y. (2018). African swine fever virus (ASFV) protection mediated by NH/P68 and NH/P68 recombinant live-attenuated viruses. Vaccine, 36(19), 2694-2704. https://doi.org/10.1016/j.vaccine.2018.03.040
Gallardo, C., Soler, A., Rodze, I., Nieto, R., Cano-Gómez, C., Fernandez-Pinero, J., & Arias, M. (2019). Attenuated and non-haemadsorbing (non-HAD) genotype II African swine fever virus (ASFV) isolated in Europe, Latvia 2017. Transboundary and Emerging Diseases, 66(3), 1399-1404. https://doi.org/10.1111/tbed.13132
Ge, S., Li, J., Fan, X., Liu, F., Li, L., Wang, Q., Ren, W., Bao, J., Liu, C., Wang, H., Liu, Y., Zhang, Y., Xu, T., Wu, X., & Wang, Z. (2018). Molecular characterization of African swine fever virus, China, 2018. Emerging Infectious Diseases, 24(11), 2131-2133. https://doi.org/10.3201/eid2411.181274
Gladue, D. P., O´Donnel, V., Ramirez-Medina, E., Rai, A., Pruitt, S., Vuono, E. A., Silva, E., Velazquez-Salinas, L., & Borca, M. V. (2020). Deletion of CD2-like (CD2v) and C-type lectin-like (EP153R) genes from African swine fever virus Georgia-9GL abrogates its effectiveness as an experimental vaccine. Viruses, 12(10), 1185. https://doi.org/10.3390/v12101185
Goatley, L. C., Reis, A. L., Portugal, R., Goldswain, H., Shimmon, G. L., Hargreaves, Z., Ho, C. S., Montoya, M., Sánchez-Cordón, P. J., Taylor, G., Dixon, L. K., & Netherton, C. L. (2020). A pool of eight virally vectored African swine fever antigens protect pigs against fatal disease. Vaccines, 8(2), 234. https://doi.org/10.3390/vaccines8020234
Gómez-Puertas, P., Rodríguez, F., Oviedo, J. M., Brun, A., Alonso, C., & Escribano, J. M. (1998). The African swine fever virus proteins p54 and p30 are involved in two distinct steps of virus attachment and both contribute to the antibody- mediated protective immune response. Virology, 243(2), 461-471. https://doi.org/10.1006/viro.1998.9068
Gómez-Puertas, P., Rodríguez, F., Oviedo, J. M., Ramiro-Ibáñez, F., Ruiz-Gonzalvo, F., Alonso, C., & Escribano, J. M. (1996). Neutralizing antibodies to different proteins of African swine fever virus inhibit both virus attachment and internalization. Journal of Virology, 70(8), 5689-5694. https://doi.org/10.1128/jvi.70.8.5689-5694.1996
Hess, W. R. (1971). African swine fever virus. Virology Monographs Die Virusforschung in Einzeldarstellungen, 9, 1-33. https://doi.org/10.1007/978-3-7091-3987-5_1
Ivanov, V., Efremov, E. E., Novikov, B. V., Balyshev, V. M., Tsibanov, S. Z., Kalinovsky, T., Kolbasov, D. V., Niedzwiecki, A., & Rath, M. (2011). Vaccination with viral protein-mimicking peptides postpones mortality in domestic pigs infected by African swine fever virus. Molecular Medicine Reports, 4(3), 395-401. https://doi.org/10.3892/mmr.2011.454
Jancovich, J. K., Chapman, D., Hansen, D. T., Robida, M. D., Loskutov, A., Craciunescu, F., Borovkov, A., Kibler, K., Goatley, L., King, K., Netherton, C. L., Taylor, G., Jacobs, B., Sykes, K., & Dixon, L. K. (2018). Immunization of pigs by DNA prime and recombinant vaccinia virus boost to identify and rank African swine fever virus immunogenic and protective proteins. Journal of Virology, 96(8), e02219-17. https://doi.org/10.1128/jvi.02219-17
Jurado, C., Fernández-Carrión, E., Mur, L., Rolesu, S., Laddomada, A., & Sánchez-Vizcaíno, J. M. (2018). Why is African swine fever still present in Sardinia? Transboundary and Emerging Diseases, 65(2), 557-566. https://doi.org/10.1111/tbed.12740
King, K., Chapman, D., Argilaguet, J. M., Fishbourne, E., Hutet, E., Cariolet, R., Hutchings, G., Oura, C. A. L., Netherton, C. L., Moffat, K., Taylor, G., Potier, M. F. L., Dixon, L. K., & Takamatsu, H. H. (2011). Protection of European domestic pigs from virulent African isolates of African swine fever virus by experimental immunisation. Vaccine, 29(28), 4593-4600. https://doi.org/10.1016/j.vaccine.2011.04.052
Krug, P. W., Holinka, L. G., O'Donnell, V., Reese, B., Sanford, B., Fernandez-Sainz, I., Gladue, D. P., Arzt, J., Rodriguez, L., Risatti, G. R., Borca, M. V. (2015). The progressive adaptation of a georgian isolate of African swine fever virus to vero cells leads to a gradual attenuation of virulence in swine corresponding to major modifications of the viral genome. Journal of Virology, 89(4), 2324-2332.
Lacasta, A., Ballester, M., Monteagudo, P. L., Rodriguez, J. M., Salas, M. L., Accensi, F., Pina-Pedrero, S., Bensaid, A., Argilaguet, J., López-Soria, S., Hutet, E., Potier, M. F. L., & Rodriguez, F. (2014). Expression library immunization can confer protection against lethal challenge with African swine fever virus. Journal of Virology, 88(22), 13322-13332. https://doi.org/10.1128/jvi.01893-14
Lacasta, A., Monteagudo, P. L., Jiménez-Marín, Á., Accensi, F., Ballester, M., Argilaguet, J., Galindo-Cardiel, I., Segalés, J., Salas, M. L., Domínguez, J., Moreno, A., Garrido, J. J., & Rodríguez, F. (2015). Live attenuated African swine fever viruses as ideal tools to dissect the mechanisms involved in viral pathogenesis and immune protection. Veterinary Research, 46(1), 135. https://doi.org/10.1186/s13567-015-0275-z
Leitão, A., Cartaxeiro, C., Coelho, R., Cruz, B., Parkhouse, R. M. E., Portugal, F. C., Vigário, J. D., & Martins, C. L. V. (2001). The non-haemadsorbing African swine fever virus isolate ASFV/NH/P68 provides a model for defining the protective anti-virus immune response. Journal of General Virology, 82(Pt3), 513-523. https://doi.org/10.1099/0022-1317-82-3-513
Lewis, T., Zsak, L., Burrage, T. G., Lu, Z., Kutish, G. F., Neilan, J. G., & Rock, D. L. (2000). An African swine fever virus ERV1-ALRHomologue, 9GL, affects virion maturation and viral growth in macrophages and viral virulence in swine. Journal of Virology, 74(3), 1275-1285. https://doi.org/10.1128/jvi.74.3.1275-1285.2000
Liu, S., Luo, Y., Wang, Y., Li, S., Zhao, Z., Bi, Y., Sun, J., Peng, R., Song, H., Zhu, D., Sun, Y., Li, S., Zhang, L., Wang, W., Sun, Y., Qi, J., Yan, J., Shi, Y., Zhang, X., … Gao, G. F. (2019). Cryo-EM Structure of the African swine fever virus. Cell Host and Microbe, 26(6), 836-843. https://doi.org/10.1016/j.chom.2019.11.004
Lokhandwala, S., Petrovan, V., Popescu, L., Sangewar, N., Elijah, C., Stoian, A., Olcha, M., Ennen, L., Bray, J., Bishop, R. P., Waghela, S. D., Sheahan, M., Rowland, R. R. R., & Mwangi, W. (2019). Adenovirus-vectored African swine fever virus antigen cocktails are immunogenic but not protective against intranasal challenge with Georgia 2007/1 isolate. Veterinary Microbiology, 235, 10-20. https://doi.org/10.1016/j.vetmic.2019.06.006
Lopera-Madrid, J., Osorio, J. E., He, Y., Xiang, Z., Adams, L. G., Laughlin, R. C., Mwangi, W., Subramanya, S., Neilan, J., Brake, D., Burrage, T. G., Brown, W. C., Clavijo, A., & Bounpheng, M. A. (2017). Safety and immunogenicity of mammalian cell derived and modified vaccinia Ankara vectored African swine fever subunit antigens in swine. Veterinary Immunology and Immunopathology, 185, 20-33. https://doi.org/10.1016/j.vetimm.2017.01.004
López, E., van Heerden, J., Bosch-Camós, L., Accensi, F., Navas, M. J., López-Monteagudo, P., Argilaguet, J., Gallardo, C., Pina-Pedrero, S., Salas, M. L., Salt, J., & Rodriguez, F. (2020). Live attenuated African swine fever viruses as ideal tools to dissect the mechanisms involved in cross-protection. Viruses, 12(12), 1474. https://doi.org/10.3390/v12121474
Malmquist, W. A. (1963). Serologic and immunologic studies with African swine fever virus. American Journal of Veterinary Research, 24, 450-459. https://pubmed.ncbi.nlm.nih.gov/13932609/
Manso-Ribeiro, J., Nunes-Petisca, J. L., Lopez-Frazao, F., & Sobral, M. (1963). Vaccination against ASF. Bulletin de l'office International des Epizooties, 60, 921-937.
Martins, C. L. V., Lawman, M. J. P., Scholl, T., Mebus, C. A., & Lunney, J. K. (1993). African swine fever virus specific porcine cytotoxic T cell activity. Archives of Virology, 129(1-4), 211-225. https://doi.org/10.1007/BF01316896
Mazur-Panasiuk, N., Woźniakowski, G., & Niemczuk, K. (2019). The first complete genomic sequences of African swine fever virus isolated in Poland. Scientific Reports, 9(1), 4556. https://doi.org/10.1038/s41598-018-36823-0
Monteagudo, P. L., Lacasta, A., López, E., Bosch, L., Collado, J., Pina-Pedrero, S., Correa-Fiz, F., Accensi, F., Navas, M. J., Vidal, E., Bustos, M. J., Rodríguez, J. M., Gallei, A., Nikolin, V., Salas, M. L., & Rodríguez, F. (2017). BA71ΔCD2: A new recombinant live attenuated African swine fever virus with cross-protective capabilities. Journal of Virology, 91(21), e01058-17. https://doi.org/10.1128/jvi.01058-17
Montgomery, E. R. (1921). On a form of swine fever occurring in British East Africa (Kenya Colony). Journal of Comparative Pathology and Therapeutics, 34, 159-191. https://doi.org/10.1016/s0368-1742(21)80031-4
Mulumba-Mfumu, L. K., Goatley, L. C., Saegerman, C., Takamatsu, H. H., & Dixon, L. K. (2016). Immunization of African indigenous pigs with attenuated genotype I African swine fever virus OURT88/3 induces protection against challenge with virulent strains of genotype I. Transboundary and Emerging Diseases, 63(5), e323-e327. https://doi.org/10.1111/tbed.12303
Neilan, J. G., Zsak, L., Lu, Z., Burrage, T. G., Kutish, G. F., & Rock, D. L. (2004). Neutralizing antibodies to African swine fever virus proteins p30, p54, and p72 are not sufficient for antibody-mediated protection. Virology, 319(2), 337-342. https://doi.org/10.1016/j.virol.2003.11.011
Niemi, J. K. (2020). Impacts of African swine fever on pigmeat markets in Europe. Frontiers in Veterinary Science, 7, 634. https://doi.org/10.3389/fvets.2020.00634
Netherton, C. L., Goatley, L. C., Reis, A. L., Portugal, R., Nash, R. H., Morgan, S. B., Gault, L., Nieto, R., Norlin, V., Gallardo, C., Ho, C. S., Sánchez-Cordón, P. K., Taylor, G., & Dixon, L. K. (2019). Identification and immunogenicity of African swine fever virus antigens. Frontiers in Immunology, 10, 1318. https://doi.org/10.3389/fimmu.2019.01318
O'Donnell, V., Holinka, L. G., Gladue, D. P., Sanford, B., Krug, P. W., Lu, X., Arzt, J., Reese, B., Carrillo, C., Risatti, G. R., & Borca, M. V. (2015). African swine fever virus Georgia isolate harboring deletions of MGF360 and MGF505 genes is attenuated in swine and confers protection against challenge with virulent parental virus. Journal of Virology, 89(11), 6048-6056. https://doi.org/10.1128/jvi.00554-15
O'Donnell, V., Holinka, L. G., Krug, P. W., Gladue, D. P., Carlson, J., Sanford, B., Alfano, M., Kramer, E., Lu, Z., Arzt, J., Reese, B., Carrillo, C., Risatti, G. R., & Borca, M. V. (2015). African swine fever virus Georgia 2007 with a deletion of virulence-associated gene 9GL (B119L), when administered at low doses, leads to virus attenuation in swine and induces an effective protection against homologous challenge. Journal of Virology, 89(16), 8556-8566. https://doi.org/10.1128/jvi.00969-15
O'Donnell, V., Holinka, L. G., Sanford, B., Krug, P. W., Carlson, J., Pacheco, J. M., Reese, B., Risatti, G. R., Gladue, D. P., & Borca, M. V. (2016). African swine fever virus Georgia isolate harboring deletions of 9GL and MGF360/505 genes is highly attenuated in swine but does not confer protection against parental virus challenge. Virus Research, 221, 8-14. https://doi.org/10.1016/j.virusres.2016.05.014
O'Donnell, V., Risatti, G. R., Holinka, L. G., Krug, P. W., Carlson, J., Velazquez-Salinas, L., Azzinaro, P. A., Gladue, D. P., & Borca, M. V. (2017). Simultaneous deletion of the 9GL and UK Genes from the African swine fever virus Georgia 2007 isolate offers increased safety and protection against homologous challenge. Journal of Virology, 91(1), e01760-16. https://doi.org/10.1128/jvi.01760-16
OIE (World Organization for Animal Health). (2021a). Listed diseases 2021. https://www.oie.int/en/animal-health-in-the-world/oie-listed-diseases-2021/
OIE (World Organization for Animal Health). (2021b). Self-declared disease status. https://www.oie.int/en/animal-health-in-the-world/self-declared-disease-status/
OIE-WAHIS (World Organization for Animal Health-World Animal Health Information System). (2021). Disease situation. https://wahis.oie.int/#/home
Onisk, D. V., Borca, M. V., Kutish, S., Kramer, E., Irusta, P., & Rock, D. L. (1994). Passively transferred African swine fever virus antibodies protect swine against lethal infection. Virology, 198(1), 350-354. https://doi.org/10.1006/viro.1994.1040
Oura, C. A. L., Denyer, M. S., Takamatsu, H., & Parkhouse, R. M. E. (2005). In vivo depletion of CD8+ T lymphocytes abrogates protective immunity to African swine fever virus. Journal of General Virology, 86(Pt9), 2445-2450. https://doi.org/10.1099/vir.0.81038-0
Penrith, M. L. (2013). History of “swine fever” in Southern Africa. Journal of the South African Veterinary Association, 84(1), a1106. https://doi.org/10.4102/jsava.v84i1.1106
Petisca, N. J. (1965). Quelques aspects morphologiques des suites de la vaccination contre la peste porcine Africaine (virose L) au Portugal. Bulletin de l’Óffice International Des Epizooties, 63, 199-237.
Petrov, A., Forth, J. H., Zani, L., Beer, M., & Blome, S. (2018). No evidence for long-term carrier status of pigs after African swine fever virus infection. Transboundary and Emerging Diseases, 65(5), 1318-1328. https://doi.org/10.1111/tbed.12881
Quembo, C. J., Jori, F., Vosloo, W., & Heath, L. (2018). Genetic characterization of African swine fever virus isolates from soft ticks at the wildlife/domestic interface in Mozambique and identification of a novel genotype. Transboundary and Emerging Diseases, 665(2), 420-431. https://doi.org/10.1111/tbed.12700
Ramirez-Medina, E., Vuono, E., O'donnell, V., Holinka, L. G., Silva, E., Rai, A., Pruitt, S., Carrillo, C., Gladue, D. P., & Borca, M. V. (2019). Differential effect of the deletion of African swine fever virus virulence-associated genes in the induction of attenuation of the highly virulent Georgia strain. Viruses, 11(7), 599. https://doi.org/10.3390/v11070599
Reis, A. L., Abrams, C. C., Goatley, L. C., Netherton, C., Chapman, D. G., Sánchez-Cordon, P., & Dixon, L. K. (2016). Deletion of African swine fever virus interferon inhibitors from the genome of a virulent isolate reduces virulence in domestic pigs and induces a protective response. Vaccine, 34(39), 4698-4705. https://doi.org/10.1016/j.vaccine.2016.08.011
Reis, A. L., Goatley, L. C., Jabbar, T., Lopez, E., Rathakrishnan, A., & Dixon, L. K. (2020). Deletion of the gene for the type I interferon inhibitor I329L from the attenuated African swine fever virus ourt88/3 strain reduces protection induced in pigs. Vaccines, 8(2), 262. https://doi.org/10.3390/vaccines8020262
Reis, A. L., Goatley, L. C., Jabbar, T., Sánchez-Cordon, P. J., Netherton, C. L., Chapman, D. A. G., & Dixon, L. K. (2017). Deletion of the African swine fever virus gene DP148R does not reduce virus replication in culture but reduces virus virulence in pigs and induces high levels of protection against challenge. Journal of Virology, 91(24), e01428-17. https://doi.org/10.1128/jvi.01428-17
Reuters. (2021). New China swine fever strains point to unlicensed vaccines. https://www.reuters.com/article/us-china-swinefever-vaccines-insight-idUSKBN29R00X
Revilla, Y., Peña, L., & Viñuela, E. (1992). Interferon-gamma production by African swine fever virus-specific lymphocytes. Scandinavian Journal of Immunology, 35(2), 225-230. https://doi.org/10.1111/j.1365-3083.1992.tb02854.x
Ruiz-Gonzalvo, F., Carnero, M. E., Caballero, C., & Martínez, J. (1986). Inhibition of African swine fever infection in the presence of immune sera in vivo and in vitro. American Journal of Veterinary Research, 47(6), 1249-1252.
Ruiz-Gonzalvo, F., Rodríguez, F., & Escribano, J. M. (1996). Functional and immunological properties of the baculovirus-expressed hemagglutinin of African swine fever virus. Virology, 218(1), 285-289. https://doi.org/10.1006/viro.1996.0193
Sánchez-Botija, C. (1963). Modificaciones del virus de la PPA en cultivos celulares. Patogenicidad y propiedades protectivas de las cepas atenuadas. Review of Animal Pathology and Biology, 7, 5-23.
Sánchez-Cordón, P. J., Chapman, D., Jabbar, T., Reis, A. L., Goatley, L., Netherton, C. L., Taylor, G., Montoya, M., & Dixon, L. (2017). Different routes and doses influence protection in pigs immunised with the naturally attenuated African swine fever virus isolate OURT88/3. Antiviral Research, 138, 1-8. https://doi.org/10.1016/j.antiviral.2016.11.021
Sánchez-Cordón, P. J., Jabbar, T., Berrezaie, M., Chapman, D., Reis, A., Sastre, P., Rueda, P., Goatley, L., & Dixon, L. K. (2018). Evaluation of protection induced by immunisation of domestic pigs with deletion mutant African swine fever virus BeninΔMGF by different doses and routes. Vaccine, 36(5), 707-715. https://doi.org/10.1016/j.vaccine.2017.12.030
Sánchez-Cordón, P. J., Jabbar, T., Chapman, D., Dixon, L. K., & Montoya, M. (2020). Absence of long-term protection in domestic pigs immunized with attenuated African swine fever virus isolate OURT88/3 or BeninΔMFG correlates with increased levels of regulatory T cells and IL-10. Journal of Virology, 94(14), e00350-20. https://doi.org/10.1128/jvi.00350-20
Sánchez-Vizcaíno, J. M., Mur, L., Gomez-Villamandos, J. C., & Carrasco, L. (2015). An update on the epidemiology and pathology of African swine fever. Journal of Comparative Pathology, 152(1), 9-21. https://doi.org/10.1016/j.jcpa.2014.09.003
Sánchez-Vizcaíno, J. M., Mur, L., & Martínez-López, B. (2013). African swine fever (ASF): Five years around Europe. Veterinary Microbiology, 165(1-2), 45-50. https://doi.org/10.1016/J.VETMIC.2012.11.030
Sanford, B., Holinka, L. G., O'Donnell, V., Krug, P. W., Carlson, J., Alfano, M., Carrillo, C., Wu, P., Lowe, A., Risatti, G. R., Gladue, D. P., & Borca, M. V. (2016). Deletion of the thymidine kinase gene induces complete attenuation of the Georgia isolate of African swine fever virus. Virus Research, 213, 165-171. https://doi.org/10.1016/j.virusres.2015.12.002
Sereda, A. D., Balyshev, V. M., Kazakova, A. S., Imatdinov, A. R., & Kolbasov, D. V. (2020). Protective properties of attenuated strains of African swine fever virus belonging to seroimmunotypes I-VIII. Pathogens, 9(4), 274. https://doi.org/10.3390/pathogens9040274
Souto, R., Mutowembwa, P., van Heerden, J., Fosgate, G. T., Heath, L., & Vosloo, W. (2016). Vaccine potential of two previously uncharacterized African swine fever virus isolates from southern Africa and heterologous cross protection of an avirulent European isolate. Transboundary and Emerging Diseases, 63(2), 224-231. https://doi.org/10.1111/tbed.12250
Stone, S. S., DeLay, P. D., & Sharman, E. C. (1968). The antibody response in pigs inoculated with attenuated African swine fever virus. Canadian Journal of Comparative Medicine. Revue Canadienne de Medecine Comparee, 32(3), 455-460.
Stone, S. S., & Hess, W. R. (1967). Antibody response to inactivated preparations of African swine fever virus in pigs. American Journal of Veterinary Research, 28(123), 475-481.
Sun, E., Zhang, Z., Wang, Z., He, X., Zhang, X., Wang, L., Wang, W., Huang, L., Xi, F., Huangfu, H., Tsegay, G., Huo, H., Sun, J., Tian, Z., Xia, W., Yu, X., Li, F., Liu, R., Guan, Y., … Bu, Z. (2021). Emergence and prevalence of naturally occurring lower virulent African swine fever viruses in domestic pigs in China in 2020. Science China Life Sciences, 64(5), 752-765. https://doi.org/10.1007/s11427-021-1904-4
Sunwoo, S. Y., Pérez-Núñez, D., Morozov, I., Sánchez, E. G., Gaudreault, N. N., Trujillo, J. D., Mur, L., Nogal, M., Madden, D., Urbaniak, K., Kim, I. J., Ma, W., Revilla, Y., & Richt, J. A. (2019). DNA-protein vaccination strategy does not protect from challenge with African swine fever virus Armenia 2007 strain. Vaccines, 7, 12. https://doi.org/10.3390/vaccines7010012
Titov, I., Burmakina, G., Morgunov, Y., Morgunov, S., Koltsov, A., Malogolovkin, A., & Kolbasov, D. (2017). Virulent strain of African swine fever virus eclipses its attenuated derivative after challenge. Archives of Virology, 162(10), 3081-3088. https://doi.org/10.1007/s00705-017-3471-5
Vigário, J. D., Terrinha, A. M., & Nunes, J. F. M. (1974). Antigenic relationships among strains of African swine fever virus. Archiv Für Die Gesamte Virusforschung, 45(3), 272-277. https://doi.org/10.1007/BF01249690
Walker, J. (1933). East African swine fever. University of Zürich. https://agris.fao.org/agris-search/search.do?recordID=US201300177871
Wang, N., Zhao, D., Wang, J., Zhang, Y., Wang, M., Gao, Y., Li, F., Wang, J., Bu, Z., Rao, Z., & Wang, X. (2019). Architecture of African swine fever virus and implications for viral assembly. Science, 366(6465), 640-644. https://doi.org/10.1126/science.aaz1439
Wardley, R. C., Norley, S. G., Wilkinson, P. J., & Williams, S. (1985). The role of antibody in protection against African swine fever virus. Veterinary Immunology and Immunopathology, 9(3), 201-212. https://doi.org/10.1016/0165-2427(85)90071-6
Wu, K., Liu, J., Wang, L., Fan, S., Li, Z., Li, Y., Yi, L., Ding, H., Zhao, M., & Chen, J. (2020). Current state of global African swine fever vaccine development under the prevalence and transmission of ASF in China. Vaccines, 8(3), 1-26. https://doi.org/10.3390/vaccines8030531
Zhang, J., Zhang, Y., Chen, T., Yang, J., Yue, H., Wang, L., Zhou, X., Qi, Y., Han, X., Ke, J., Wang, S., Yang, J., Miao, F., Zhang, S., Zhang, F., Wang, Y., Li, M., & Hu, R. (2021). Deletion of the L7L-L11L genes attenuates ASFV and induces protection against homologous challenge. Viruses, 13(2), 255. https://doi.org/10.3390/v13020255
Zhao, D., Liu, R., Zhang, X., Li, F., Wang, J., Zhang, J., Liu, X., Wang, L., Zhang, J., Wu, X., Guan, Y., Chen, W., Wang, X., He, X., & Bu, Z. (2019). Replication and virulence in pigs of the first African swine fever virus isolated in China. Emerging Microbes and Infections, 8(1), 438-447. https://doi.org/10.1080/22221751.2019.1590128
Zhou, X., Li, N., Luo, Y., Liu, Y., Miao, F., Chen, T., Zhang, S., Cao, P., Li, X., Tian, K., Qiu, H. J., & Hu, R. (2018). Emergence of African swine fever in China, 2018. Transboundary and Emerging Diseases, 65(6), 1482-1484. https://doi.org/10.1111/tbed.12989
Zsak, L., Onisk, D. V., Afonso, C. L., & Rock, D. L. (1993). Virulent African swine fever virus isolates are neutralized by swine immune serum and by monoclonal antibodies recognizing a 72-kDa viral protein. Virology, 196(2), 596-602. https://doi.org/10.1006/viro.1993.1515