Development of [
Animals
Cytochrome P-450 CYP11B2
/ analysis
Cytochrome P-450 Enzyme Inhibitors
/ chemical synthesis
Dose-Response Relationship, Drug
Drug Development
Female
Fluorine Radioisotopes
Humans
Hyperaldosteronism
/ diagnostic imaging
Mice
Mice, Inbred BALB C
Molecular Structure
Positron-Emission Tomography
Structure-Activity Relationship
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
08 07 2021
08 07 2021
Historique:
pubmed:
18
6
2021
medline:
8
9
2021
entrez:
17
6
2021
Statut:
ppublish
Résumé
The purpose of this study was to synthesize a fluorine-18 labeled, highly selective aldosterone synthase (
Identifiants
pubmed: 34137616
doi: 10.1021/acs.jmedchem.1c00539
pmc: PMC8273890
doi:
Substances chimiques
Cytochrome P-450 Enzyme Inhibitors
0
Fluorine Radioisotopes
0
Cytochrome P-450 CYP11B2
EC 1.14.15.4
Fluorine-18
GZ5I74KB8G
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9321-9329Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 102407/Z/13/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T005769/1
Pays : United Kingdom
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