How glucagon-like peptide 1 receptor agonists work.
cardiovascular
diabetes
inflammation
metabolism
obesity
Journal
Endocrine connections
ISSN: 2049-3614
Titre abrégé: Endocr Connect
Pays: England
ID NLM: 101598413
Informations de publication
Date de publication:
17 Jul 2021
17 Jul 2021
Historique:
received:
26
05
2021
accepted:
16
06
2021
pubmed:
18
6
2021
medline:
18
6
2021
entrez:
17
6
2021
Statut:
epublish
Résumé
In recent years, glucagon-like peptide 1 receptor agonists (GLP-1RAs) have become central in the treatment of type 2 diabetes (T2D). In addition to their glucose-lowering properties with low risk of hypoglycaemia, GLP-1RAs reduce body weight and show promising results in reducing cardiovascular risk and renal complications in high-risk individuals with T2D. These findings have changed guidelines on T2D management over the last years, and GLP-1RAs are now widely used in overweight patients with T2D as well as in patients with T2D and cardiovascular disease regardless of glycaemic control. The currently available GLP-1RAs have different pharmacokinetic profiles and differ in their ability to improve glycaemia, reduce body weight and in their cardio- and renal protective potentials. Understanding how these agents work, including insights into their pleiotropic effects on T2D pathophysiology, may improve their clinical utilisation and be useful for exploring other indications such as non-alcoholic steatohepatitis and neurodegenerative disorders. In this review, we provide an overview of approved GLP-1RAs, their clinical effects and mode of action, and we offer insights into the potential of GLP-1RAs for other indications than T2D. Finally, we will discuss the emerging data and therapeutic potential of using GLP-1RAs in combinations with other receptor agonists.
Identifiants
pubmed: 34137731
doi: 10.1530/EC-21-0130
pii: EC-21-0130.R1
pmc: PMC8346189
doi:
pii:
Types de publication
Journal Article
Review
Langues
eng
Pagination
R200-R212Références
Lancet. 2014 Oct 11;384(9951):1349-57
pubmed: 25018121
J Clin Endocrinol Metab. 2021 Jan 23;106(2):388-396
pubmed: 33236115
Front Aging Neurosci. 2016 May 24;8:108
pubmed: 27252647
Diabetes Care. 2016 Oct;39(10):1702-10
pubmed: 27506222
BMJ Open Diabetes Res Care. 2020 Oct;8(2):
pubmed: 33115821
N Engl J Med. 2017 Sep 28;377(13):1228-1239
pubmed: 28910237
J Clin Invest. 2002 Jul;110(1):43-52
pubmed: 12093887
Endocrinology. 2018 Apr 1;159(4):1570-1584
pubmed: 29444223
Atherosclerosis. 2017 Oct;265:283-291
pubmed: 28693828
Lancet Diabetes Endocrinol. 2014 Feb;2(2):152-64
pubmed: 24622719
JAMA Neurol. 2019 Apr 1;76(4):420-429
pubmed: 30640362
Arterioscler Thromb Vasc Biol. 2012 Jun;32(6):1513-9
pubmed: 22492091
Endocr Rev. 2021 Mar 15;42(2):101-132
pubmed: 33320179
Diabetes Care. 2015 Jan;38(1):132-9
pubmed: 25414155
Diabetes Care. 2018 Feb;41(2):258-266
pubmed: 29246950
Diabetes Care. 2017 Jul;40(7):966-972
pubmed: 28476871
Lancet Diabetes Endocrinol. 2020 Apr;8(4):313-324
pubmed: 32135138
Diabetes Care. 2004 Nov;27(11):2628-35
pubmed: 15504997
Lancet Diabetes Endocrinol. 2018 Apr;6(4):275-286
pubmed: 29397376
J Clin Endocrinol Metab. 2020 Mar 1;105(3):
pubmed: 31608926
Diabetes Obes Metab. 2013 Oct;15(10):871-81
pubmed: 23425609
Neurosci Biobehav Rev. 2007;31(7):1046-63
pubmed: 17544131
Circ Res. 2014 May 23;114(11):1788-803
pubmed: 24855202
Arterioscler Thromb Vasc Biol. 2020 Jan;40(1):145-158
pubmed: 31747801
Diabetes Obes Metab. 2017 Jun;19(6):906-908
pubmed: 28105738
Am J Physiol Renal Physiol. 2015 Apr 15;308(8):F867-77
pubmed: 25656368
N Engl J Med. 2019 Aug 29;381(9):841-851
pubmed: 31185157
Clin Med Insights Endocrinol Diabetes. 2020 Feb 14;13:1179551420905844
pubmed: 32110131
Diabetes Care. 2021 Jan;44(1):290-296
pubmed: 33444163
N Engl J Med. 2016 Nov 10;375(19):1834-1844
pubmed: 27633186
Nat Rev Nephrol. 2017 Oct;13(10):605-628
pubmed: 28869249
Diabetes Care. 2019 Dec;42(12):2272-2281
pubmed: 31530666
JACC Basic Transl Sci. 2018 Nov 21;3(6):844-857
pubmed: 30623143
Diabetes Obes Metab. 2020 Apr;22(4):640-647
pubmed: 31808298
Lancet Diabetes Endocrinol. 2014 Apr;2(4):289-297
pubmed: 24703047
Diabetes Care. 2014 Jul;37(7):1938-43
pubmed: 24667461
Obesity (Silver Spring). 2016 Nov;24(11):2278-2288
pubmed: 27804269
Lancet Diabetes Endocrinol. 2020 Apr;8(4):262-264
pubmed: 32135134
Clin Ther. 2015 Jan 1;37(1):225-241.e8
pubmed: 25554560
Diabetes Care. 2020 Jan;43(Suppl 1):S98-S110
pubmed: 31862752
Mol Metab. 2017 Nov;6(11):1339-1349
pubmed: 29107282
Diabetes Care. 2013 Oct;36(10):2945-51
pubmed: 23698396
JAMA. 2015 Aug 18;314(7):687-99
pubmed: 26284720
J Pathol. 2018 May;245(1):85-100
pubmed: 29435980
Clin Pharmacokinet. 2019 Sep;58(9):1193-1203
pubmed: 30945118
J Clin Endocrinol Metab. 2002 Mar;87(3):1239-46
pubmed: 11889194
Sci Adv. 2020 Aug 26;6(35):eaaz9890
pubmed: 32923621
Lancet. 2016 Feb 13;387(10019):679-90
pubmed: 26608256
Lancet. 2013 Jan 12;381(9861):117-24
pubmed: 23141817
Diabetes Care. 2021 Mar;44(3):765-773
pubmed: 33397768
J Clin Endocrinol Metab. 2019 Jul 1;104(7):2463-2472
pubmed: 30137354
Appetite. 2018 Aug 1;127:334-340
pubmed: 29782892
Diabetes. 2012 Apr;61(4):888-96
pubmed: 22357961
Surg Obes Relat Dis. 2018 May;14(5):708-714
pubmed: 29776493
Diabetes Care. 2016 Sep;39(9):1501-9
pubmed: 27311491
Curr Diabetes Rev. 2013 Mar 1;9(2):161-93
pubmed: 23256660
N Engl J Med. 2021 Mar 25;384(12):1113-1124
pubmed: 33185364
Cochrane Database Syst Rev. 2020 Jul 23;7:CD012990
pubmed: 32700772
Physiol Rev. 2007 Oct;87(4):1409-39
pubmed: 17928588
Diabetes Care. 2010 May;33(5):1028-30
pubmed: 20200309
Front Neurosci. 2018 Nov 13;12:830
pubmed: 30542257
Nat Rev Endocrinol. 2018 Jul;14(7):390-403
pubmed: 29728598
Lancet Diabetes Endocrinol. 2019 Oct;7(10):776-785
pubmed: 31422062
Nat Rev Endocrinol. 2012 Dec;8(12):728-42
pubmed: 22945360
Lancet. 2019 Jul 13;394(10193):121-130
pubmed: 31189511
Diabetologia. 2006 Mar;49(3):452-8
pubmed: 16447057
Lancet Diabetes Endocrinol. 2016 Mar;4(3):221-232
pubmed: 26656289
J Gastroenterol Hepatol. 2016 Jan;31(1):23-31
pubmed: 26111358
Clin J Am Soc Nephrol. 2016 Aug 8;11(8):1384-91
pubmed: 27340284
JCI Insight. 2020 Mar 26;5(6):
pubmed: 32213703
Mol Metab. 2019 Dec;30:72-130
pubmed: 31767182
Diabetes. 2011 May;60(5):1561-5
pubmed: 21430088
Medicina (Kaunas). 2019 May 31;55(6):
pubmed: 31159279
Lancet. 2008 Oct 4;372(9645):1240-50
pubmed: 18782641
Lancet. 2019 Jul 6;394(10192):39-50
pubmed: 31186120
Lancet. 2009 Jul 4;374(9683):39-47
pubmed: 19515413
N Engl J Med. 2016 Jul 28;375(4):311-22
pubmed: 27295427
Diabetes Care. 2016 Oct;39(10):1693-701
pubmed: 27493132
Diabetes Care. 2014 Aug;37(8):2159-67
pubmed: 24879836
Life Sci. 2020 Jun 1;250:117531
pubmed: 32151691
Lancet. 2017 Oct 7;390(10103):1664-1675
pubmed: 28781108
Nat Med. 2018 Jul;24(7):931-938
pubmed: 29892066
Hepatology. 2017 Mar;65(3):950-968
pubmed: 27880981
N Engl J Med. 2015 Dec 3;373(23):2247-57
pubmed: 26630143
Gut. 2006 Feb;55(2):243-51
pubmed: 15985560
Endocrinology. 1999 Apr;140(4):1687-94
pubmed: 10098504
Diabetes Care. 2013 Aug;36(8):2346-50
pubmed: 23564922
Diabetes. 2010 Jul;59(7):1765-70
pubmed: 20150286
Eur J Pharmacol. 2018 Jan 5;818:103-109
pubmed: 29066413
Diabetes Obes Metab. 2017 Sep;19(9):1242-1251
pubmed: 28266779
Diabetes. 2010 Apr;59(4):1030-7
pubmed: 20068138
N Engl J Med. 2021 Mar 18;384(11):989
pubmed: 33567185
Sci Rep. 2019 Feb 20;9(1):2375
pubmed: 30787365
Cell Metab. 2019 Feb 5;29(2):246-253
pubmed: 30726758