Enhanced virulence of Plasmodium falciparum in blood of diabetic patients.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2021
2021
Historique:
received:
04
10
2020
accepted:
22
03
2021
entrez:
17
6
2021
pubmed:
18
6
2021
medline:
25
2
2023
Statut:
epublish
Résumé
Rising prevalence of diabetes in sub-Saharan Africa, coupled with continued malaria transmission, has resulted more patients dealing with both communicable and non-communicable diseases. We previously reported that travelers with type 2 diabetes mellitus (T2DM) infected with Plasmodium falciparum were three times more likely to develop severe malaria than non-diabetics. Here we explore the biological basis for this by testing blood from uninfected subjects with type 1 and type 2 diabetes, ex vivo, for their effects on parasite growth and rosetting (binding of infected erythrocytes to uninfected erythrocytes). Rosetting was associated with type 2 diabetes, blood glucose and erythrocyte sedimentation rate (ESR), while parasite growth was positively associated with blood glucose, glycated hemoglobin (HbA1c), body mass index (BMI), fibrinogen and triglycerides. This study establishes a link between diabetes and malaria virulence assays, potentially explaining the protective effect of good glycemic control against severe malaria in subjects with diabetes.
Identifiants
pubmed: 34138868
doi: 10.1371/journal.pone.0249666
pii: PONE-D-20-31196
pmc: PMC8211161
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0249666Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Microbiol Spectr. 2016 Dec;4(6):
pubmed: 28084206
J Exp Med. 1992 Nov 1;176(5):1311-7
pubmed: 1402677
Science. 1967 Aug 18;157(3790):829-31
pubmed: 17842794
Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17471-6
pubmed: 17959777
Am J Trop Med Hyg. 1992 May;46(5):589-94
pubmed: 1599053
Phys Rev Lett. 2013 Jan 4;110(1):018102
pubmed: 23383842
Trends Parasitol. 2014 Apr;30(4):170-5
pubmed: 24636355
Diabetologia. 2008 Mar;51(3):493-501
pubmed: 18183363
BMJ Open Diabetes Res Care. 2017 Jan 5;5(1):e000304
pubmed: 28191320
Clin Infect Dis. 2017 Sep 15;65(6):949-958
pubmed: 28510633
Circ Res. 1966 Apr;18(4):437-46
pubmed: 4952703
Biorheology. 1999;36(4):287-97
pubmed: 10690265
J Exp Med. 1989 May 1;169(5):1835-40
pubmed: 2654325
Clin Hemorheol Microcirc. 2006;35(1-2):307-10
pubmed: 16899949
Sci Rep. 2016 Jul 11;6:29317
pubmed: 27403804
J Med. 1989;20(3-4):297-302
pubmed: 2809426
Emerg Infect Dis. 2010 Oct;16(10):1601-4
pubmed: 20875289
Clin Hemorheol Microcirc. 2006;35(1-2):261-4
pubmed: 16899939
Lancet. 1990 Dec 15;336(8729):1457-60
pubmed: 1979090
Nat Rev Microbiol. 2017 Aug;15(8):479-491
pubmed: 28603279
Sci Rep. 2018 Feb 19;8(1):3262
pubmed: 29459776
Br J Haematol. 1992 Dec;82(4):757-63
pubmed: 1482664
Microcirculation. 2008 Oct;15(7):585-90
pubmed: 18608991
J Diabetes Sci Technol. 2008 Nov;2(6):1130-8
pubmed: 19885302
Sci Rep. 2014 Mar 11;4:4348
pubmed: 24614613
Blood. 1987 Nov;70(5):1572-6
pubmed: 3663946
Cell Rep. 2016 Feb 2;14(4):723-736
pubmed: 26776517
Clin Sci (Lond). 1992 Mar;82(3):309-13
pubmed: 1312416
Nat Med. 1996 Feb;2(2):204-8
pubmed: 8574966
Nat Med. 2015 Apr;21(4):314-7
pubmed: 25751816
Diabetol Metab Syndr. 2011 Jan 14;3(1):2
pubmed: 21232158
Biorheology. 2009;46(1):63-72
pubmed: 19252229
Lancet Diabetes Endocrinol. 2017 Aug;5(8):622-667
pubmed: 28688818
Am J Trop Med Hyg. 1992 May;46(5):503-10
pubmed: 1599043
World Health Organ Tech Rep Ser. 2000;894:i-xii, 1-253
pubmed: 11234459
J Parasitol. 1983 Dec;69(6):1060-7
pubmed: 6371212
Infect Immun. 1995 Jun;63(6):2323-6
pubmed: 7768616
J Control Release. 2016 Nov 10;241:57-67
pubmed: 27620073
Exp Parasitol. 1999 Dec;93(4):215-24
pubmed: 10600447
Malar J. 2013 Dec 07;12:442
pubmed: 24314058
J Gen Physiol. 1973 May;61(5):638-54
pubmed: 4705641