Vaginal bacterial load in the second trimester is associated with early preterm birth recurrence: a nested case-control study.
Adult
Bacterial Load
Case-Control Studies
Female
Fetal Membranes, Premature Rupture
/ epidemiology
Gestational Age
Humans
Lactobacillus
/ genetics
Lactobacillus crispatus
/ genetics
Microbiota
/ genetics
Pregnancy
Pregnancy Trimester, Second
Premature Birth
/ epidemiology
RNA, Ribosomal, 16S
/ genetics
Vagina
/ microbiology
Young Adult
Lactobacillus
preterm premature rupture of membranes
spontaneous preterm birth
vaginal microbiome
Journal
BJOG : an international journal of obstetrics and gynaecology
ISSN: 1471-0528
Titre abrégé: BJOG
Pays: England
ID NLM: 100935741
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
accepted:
17
05
2021
pubmed:
18
6
2021
medline:
17
12
2021
entrez:
17
6
2021
Statut:
ppublish
Résumé
To assess the association between vaginal microbiome (VMB) composition and recurrent early spontaneous preterm birth (sPTB)/preterm prelabour rupture of membranes (PPROM). Nested case-control study. UK tertiary referral hospital. High-risk women with previous sPTB/PPROM <34 Vaginal swabs collected between 15 and 22 weeks' gestation were analysed by 16S rRNA gene sequencing and 16S quantitative PCR. Recurrent early sPTB/PPROM. Of the 109 high-risk women, 28 had anaerobic vaginal dysbiosis, with the remainder dominated by lactobacilli (Lactobacillus iners 36/109, Lactobacillus crispatus 23/109, or other 22/109). VMB type and diversity were not associated with recurrence. Women with a recurrence, compared to those without, had a higher median vaginal bacterial load (8.64 versus 7.89 log Vaginal bacterial load is associated with early sPTB/PPROM recurrence. Domination by lactobacilli other than L. iners may protect women from developing high bacterial loads. Future PTB studies should quantify vaginal bacteria and yeasts. Increased vaginal bacterial load in the second trimester may be associated with recurrent early spontaneous preterm birth.
Identifiants
pubmed: 34139060
doi: 10.1111/1471-0528.16816
doi:
Substances chimiques
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2061-2072Informations de copyright
© 2021 John Wiley & Sons Ltd.
Références
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