Ultrasound-mediated disruption of the blood tumor barrier for improved therapeutic delivery.
Animals
Biological Transport
/ radiation effects
Biological Variation, Population
Blood-Brain Barrier
/ metabolism
Brain Neoplasms
/ drug therapy
Disease Models, Animal
Drug Delivery Systems
High-Intensity Focused Ultrasound Ablation
/ adverse effects
Humans
Neoplasm Metastasis
Permeability
/ radiation effects
Treatment Outcome
Tumor Microenvironment
/ drug effects
Ultrasonic Therapy
Ultrasonic Waves
Blood-brain barrier
Blood-tumor barrier
Disruption
Drug delivery
Focused ultrasound
Permeability
Journal
Neoplasia (New York, N.Y.)
ISSN: 1476-5586
Titre abrégé: Neoplasia
Pays: United States
ID NLM: 100886622
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
17
03
2021
revised:
28
04
2021
accepted:
30
04
2021
pubmed:
18
6
2021
medline:
18
1
2022
entrez:
17
6
2021
Statut:
ppublish
Résumé
The blood-brain barrier (BBB) is a major anatomical and physiological barrier limiting the passage of drugs into brain. Central nervous system tumors can impair the BBB by changing the tumor microenvironment leading to the formation of a leaky barrier, known as the blood-tumor barrier (BTB). Despite the change in integrity, the BTB remains effective in preventing delivery of chemotherapy into brain tumors. Focused ultrasound is a unique noninvasive technique that can transiently disrupt the BBB and increase accumulation of drugs within targeted areas of the brain. Herein, we summarize the current understanding of different types of targeted ultrasound mediated BBB/BTB disruption techniques. We also discuss influence of the tumor microenvironment on BBB opening, as well as the role of immunological response following disruption. Lastly, we highlight the gaps between evaluation of the parameters governing opening of the BBB/BTB. A deeper understanding of physical opening of the BBB/BTB and the biological effects following disruption can potentially enhance treatment strategies for patients with brain tumors.
Identifiants
pubmed: 34139452
pii: S1476-5586(21)00025-7
doi: 10.1016/j.neo.2021.04.005
pmc: PMC8208897
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
676-691Subventions
Organisme : NCI NIH HHS
ID : F99 CA253768
Pays : United States
Organisme : NCI NIH HHS
ID : F99 CA264445
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM121322
Pays : United States
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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