Water temperature affects the biotransformation and accumulation of a psychoactive pharmaceutical and its metabolite in aquatic organisms.
Aquatic invertebrate
Benzodiazepine
Dragonfly
Drug
Fish
Temazepam
Journal
Environment international
ISSN: 1873-6750
Titre abrégé: Environ Int
Pays: Netherlands
ID NLM: 7807270
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
03
05
2021
revised:
07
06
2021
accepted:
07
06
2021
pubmed:
18
6
2021
medline:
12
8
2021
entrez:
17
6
2021
Statut:
ppublish
Résumé
Pharmaceutically active compounds (PhACs) have been shown to accumulate in aquatic and riparian food-webs. Yet, our understanding of how temperature, a key environmental factor in nature, affects uptake, biotransformation, and the subsequent accumulation of PhACs in aquatic organisms is limited. In this study, we tested to what extent bioconcentration of an anxiolytic drugs (temazepam and oxazepam) is affected by two temperature regimes (10 and 20 °C) and how the temperature affects the temazepam biotransformation and subsequent accumulation of its metabolite (oxazepam) in aquatic organisms. We used European perch (Perca fluviatilis) and dragonfly larvae (Sympetrum sp.), which represent predator and prey species of high ecological relevance in food chains of boreal and temperate aquatic ecosystems. Experimental organisms were exposed to target pharmaceuticals at a range of concentrations (0.2-6 µg L
Identifiants
pubmed: 34139590
pii: S0160-4120(21)00330-5
doi: 10.1016/j.envint.2021.106705
pii:
doi:
Substances chimiques
Pharmaceutical Preparations
0
Water Pollutants, Chemical
0
Water
059QF0KO0R
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
106705Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.