THE EFFECTS OF ETANERCEPT AND CABERGOLINE ON ENDOMETRIOTIC IMPLANTS, UTERUS AND OVARIES IN RAT ENDOMETRIOSIS MODEL.


Journal

Journal of reproductive immunology
ISSN: 1872-7603
Titre abrégé: J Reprod Immunol
Pays: Ireland
ID NLM: 8001906

Informations de publication

Date de publication:
08 2021
Historique:
received: 07 03 2021
revised: 10 05 2021
accepted: 25 05 2021
pubmed: 18 6 2021
medline: 27 1 2022
entrez: 17 6 2021
Statut: ppublish

Résumé

The pathophysiology of endometriosis is still unknown and treatment options remain controversial. Searches focus on angiogenesis, stem cells, immunologic and inflammatory factors. This study investigated the effects of etanercept and cabergoline on ovaries, ectopic, and eutopic endometrium in an endometriosis rat model. This randomized, placebo-controlled, blinded study included 50 rats, Co(control), Sh(Sham), Cb(cabergoline), E(etanercept), and E + Cb(etanercept + cabergoline) groups. After surgical induction of endometriosis, 2

Identifiants

pubmed: 34139652
pii: S0165-0378(21)00070-X
doi: 10.1016/j.jri.2021.103340
pii:
doi:

Substances chimiques

Tumor Necrosis Factor-alpha 0
Vascular Endothelial Growth Factor A 0
vascular endothelial growth factor A, rat 0
Cabergoline LL60K9J05T
Etanercept OP401G7OJC

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

103340

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Cihan Deniz Keleş (CD)

Department of Obstetrics & Gynecology, Milas Government Hospital, Muğla, Turkey.

Birol Vural (B)

Department of Obstetrics & Gynecology, Assisted Reproductive Technology Unit, Şişli Kolan International Hospital, İstanbul, Turkey. Electronic address: vuralbirol@yahoo.com.tr.

Serdar Filiz (S)

Department of Histology & Embryology, Assisted Reprodoctive Technology Unit, Kocaeli University School of Medicine, Kocaeli, Turkey.

Fisun Vural (F)

Department of Obstetrics & Gynecology, Haydarpaşa Numune Training and Research Hospital, Health Sciences University, Hamidiye Medical Faculty, Istanbul, Turkey.

Gülçin Gacar (G)

Center for Stem Cell and Gene Therapies Research and Practice, Institute of Health Sciences, Kocaeli University School of Medicine, Kocaeli, Turkey.

Fatma Ceyla Eraldemir (FC)

Department of Medical Biochemistry, Kocaeli University School of Medicine, Kocaeli, Turkey.

Sema Kurnaz (S)

Department of Histology & Embryology, Kocaeli University School of Medicine, Kocaeli, Turkey.

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Classifications MeSH