Performance of Xpert MTB/RIF Ultra for tuberculosis diagnosis in the context of passive and active case finding.
Journal
The European respiratory journal
ISSN: 1399-3003
Titre abrégé: Eur Respir J
Pays: England
ID NLM: 8803460
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
27
01
2021
accepted:
11
05
2021
pubmed:
19
6
2021
medline:
27
1
2022
entrez:
18
6
2021
Statut:
epublish
Résumé
We present a field evaluation of the diagnostic accuracy of Xpert MTB/RIF ("Xpert") and Xpert MTB/RIF Ultra ("Ultra") using two cohorts in a high tuberculosis/HIV burden setting in Southern Mozambique. Single respiratory specimens from symptomatic adults accessing healthcare services (passive case finding (PCF) cohort) and from household and community close contacts (active case finding (ACF) cohort) were tested by smear microscopy, culture, Xpert and Ultra. Liquid and solid culture served as a composite reference standard. We explored the impact of trace results on specificity 1419 and 252 participants were enrolled in the PCF and ACF cohorts, respectively. For the PCF cohort, Ultra showed higher sensitivity than Xpert overall (0.95 (95% CI 0.90-0.98) These results add evidence on the improved sensitivity of Ultra and support its use in different case finding scenarios.
Identifiants
pubmed: 34140293
pii: 13993003.00257-2021
doi: 10.1183/13993003.00257-2021
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIBIB NIH HHS
ID : U54 EB027049
Pays : United States
Informations de copyright
Copyright ©The authors 2021. For reproduction rights and permissions contact permissions@ersnet.org.
Déclaration de conflit d'intérêts
Conflict of interest: B. Saavedra has nothing to disclose. Conflict of interest: E. Mambuque has nothing to disclose. Conflict of interest: D. Nguenha has nothing to disclose. Conflict of interest: N. Gomes has nothing to disclose. Conflict of interest: S. Munguambe has nothing to disclose. Conflict of interest: J.I. Garcia has nothing to disclose. Conflict of interest: S. Izco has nothing to disclose. Conflict of interest: S. Acacio has nothing to disclose. Conflict of interest: A. Murias-Closas has nothing to disclose. Conflict of interest: M. Cossa has nothing to disclose. Conflict of interest: I. Losada has nothing to disclose. Conflict of interest: H. Pernas-Pardavila has nothing to disclose. Conflict of interest: L. Oliveras has nothing to disclose. Conflict of interest: G. Theron has nothing to disclose. Conflict of interest: A.L. García-Basteiro has nothing to disclose.