Inhibitors Targeting YAP in Gastric Cancer: Current Status and Future Perspectives.
Hippo pathway
Yes-associated protein
gastric adenocarcinoma
small molecule inhibitor
targeted therapy
Journal
Drug design, development and therapy
ISSN: 1177-8881
Titre abrégé: Drug Des Devel Ther
Pays: New Zealand
ID NLM: 101475745
Informations de publication
Date de publication:
2021
2021
Historique:
received:
25
02
2021
accepted:
19
05
2021
entrez:
18
6
2021
pubmed:
19
6
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Gastric cancer (GC) is one of the most common cancers globally, threatening global health. The deregulation of the Hippo signaling pathway has been discovered in GC and may be related to cancer development, proliferation, metastasis, and drug resistance. Yes-associated protein (YAP), as a downstream effector of the Hippo signaling pathway and a crucial co-transcription factor in the nucleus, is a promising and vital potential drug target for the treatment of GC. A series of drugs or compounds that inhibit YAP has been developed or confirmed. Therefore, this review will focus on summarizing the drugs and small-molecule inhibitors that have been reported to inhibit YAP and discuss the clinical prospects of YAP inhibitors in GC.
Identifiants
pubmed: 34140763
doi: 10.2147/DDDT.S308377
pii: 308377
pmc: PMC8203099
doi:
Substances chimiques
Antineoplastic Agents
0
YAP-Signaling Proteins
0
YAP1 protein, human
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2445-2456Informations de copyright
© 2021 Yong et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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