Sunday Driver Mediates Multi-Compartment Golgi Outposts Defects Induced by Amyloid Precursor Protein.
Golgi outposts
Sunday driver
amyloid precursor protein
dendrite defects
motor protein
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2021
2021
Historique:
received:
28
02
2021
accepted:
19
04
2021
entrez:
18
6
2021
pubmed:
19
6
2021
medline:
19
6
2021
Statut:
epublish
Résumé
Golgi defects including Golgi fragmentation are pathological features of Alzheimer's disease (AD). As a pathogenic factor in AD, amyloid precursor protein (APP) induces Golgi fragmentation in the soma. However, how APP regulates Golgi outposts (GOs) in dendrites remains unclear. Given that APP resides in and affects the movements of GOs, and in particular, reverses the distribution of multi-compartment GOs (mcGOs), we investigated the regulatory mechanism of mcGO movements in the
Identifiants
pubmed: 34140878
doi: 10.3389/fnins.2021.673684
pmc: PMC8205063
doi:
Types de publication
Journal Article
Langues
eng
Pagination
673684Informations de copyright
Copyright © 2021 Du, Chang, Cheng, Zhao and Zhou.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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