Characterization of purinergic receptor 2 signaling in podocytes from diabetic kidneys.
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
25 Jun 2021
25 Jun 2021
Historique:
received:
03
12
2020
revised:
12
04
2021
accepted:
08
05
2021
entrez:
18
6
2021
pubmed:
19
6
2021
medline:
19
6
2021
Statut:
epublish
Résumé
Growing evidence suggests that renal purinergic signaling undergoes significant remodeling during pathophysiological conditions such as diabetes. This study examined the renal P2 receptor profile and ATP-mediated calcium response from podocytes in glomeruli from kidneys with type 1 or type 2 diabetic kidney disease (DKD), using type 2 diabetic nephropathy (T2DN) rats and streptozotocin-injected Dahl salt-sensitive (type 1 diabetes) rats. A dramatic increase in the ATP-mediated intracellular calcium flux in podocytes was observed in both models. Pharmacological inhibition established that P2X
Identifiants
pubmed: 34142040
doi: 10.1016/j.isci.2021.102528
pii: S2589-0042(21)00496-X
pmc: PMC8188476
doi:
Types de publication
Journal Article
Langues
eng
Pagination
102528Subventions
Organisme : NCRR NIH HHS
ID : M01 RR000058
Pays : United States
Organisme : BLRD VA
ID : I01 BX004024
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL134643
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL135749
Pays : United States
Organisme : NIDDK NIH HHS
ID : R00 DK105160
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK126720
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no competing interests.
Références
Kidney Int. 2004 Jul;66(1):157-66
pubmed: 15200422
Kidney Int. 2015 Nov;88(5):1079-87
pubmed: 26108066
Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19619-19625
pubmed: 31506348
Diabetes. 2004 Mar;53(3):735-42
pubmed: 14988259
Sci Rep. 2015 Dec 10;5:17637
pubmed: 26656101
Am J Physiol Renal Physiol. 2001 Dec;281(6):F1075-81
pubmed: 11704558
Biochem Biophys Res Commun. 2008 Dec 19;377(3):803-8
pubmed: 18938136
BMC Nephrol. 2020 May 29;21(1):206
pubmed: 32471386
J Am Soc Nephrol. 2020 Oct;31(10):2341-2354
pubmed: 32651223
Purinergic Signal. 2013 Sep;9(3):307-24
pubmed: 23546842
Front Pharmacol. 2017 Nov 22;8:860
pubmed: 29213241
Am J Physiol Renal Physiol. 2019 Nov 1;317(5):F1241-F1252
pubmed: 31545927
Compr Physiol. 2011 Jul;1(3):1175-232
pubmed: 23733640
Am J Physiol Renal Physiol. 2013 Jul 1;305(1):F134-41
pubmed: 23594827
Am J Physiol Cell Physiol. 2013 Nov 15;305(10):C1050-9
pubmed: 24048730
J Clin Invest. 2014 May;124(5):2050-8
pubmed: 24713653
Am J Physiol Renal Physiol. 2012 Oct 15;303(8):F1207-15
pubmed: 22859404
Biochem Biophys Res Commun. 2015 Nov 20;467(3):484-90
pubmed: 26456657
Physiol Rev. 2020 Jan 1;100(1):211-269
pubmed: 31437091
Am J Physiol Regul Integr Comp Physiol. 2013 Oct 1;305(7):R727-34
pubmed: 23926133
Mol Pharmacol. 2007 Dec;72(6):1447-56
pubmed: 17785580
J Am Soc Nephrol. 2009 Jun;20(6):1275-81
pubmed: 19389853
Am J Physiol Renal Physiol. 2014 May 1;306(9):F1088-97
pubmed: 24553432
Front Physiol. 2013 Aug 15;4:216
pubmed: 23966951
Nephron Exp Nephrol. 2005;101(1):e24-30
pubmed: 15925905
Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F1091-F1097
pubmed: 29923767
J Am Soc Nephrol. 2018 Jul;29(7):1917-1927
pubmed: 29793963
Am J Physiol Renal Physiol. 2019 Dec 1;317(6):F1450-F1461
pubmed: 31566426
Clin Biochem. 2009 Feb;42(3):215-20
pubmed: 19013142
Tohoku J Exp Med. 1976 May;119(1):85-90
pubmed: 951706
J Am Soc Nephrol. 2011 Sep;22(9):1696-706
pubmed: 21636640
J Am Soc Nephrol. 2010 Nov;21(11):1903-11
pubmed: 20813869
Am J Kidney Dis. 2018 Jun;71(6):884-895
pubmed: 29398179
Eur Heart J. 1983 Dec;4 Suppl H:43-50
pubmed: 6662132
Kidney Int. 2006 Nov;70(9):1599-606
pubmed: 16969386
J Am Soc Nephrol. 2019 Apr;30(4):533-545
pubmed: 30846559
Diabetes. 2018 Nov;67(11):2206-2212
pubmed: 30131395
Kidney Int. 2017 Feb;91(2):315-323
pubmed: 27780585
Diabetologia. 1997 Apr;40(4):367-73
pubmed: 9112012
EBioMedicine. 2017 May;19:73-83
pubmed: 28434946
Oncogene. 2003 Nov 24;22(53):8619-27
pubmed: 14634623
J Pathol. 2013 Nov;231(3):342-53
pubmed: 23843215
Am J Physiol Renal Physiol. 2019 Apr 1;316(4):F758-F767
pubmed: 30724104
Front Physiol. 2013 Sep 19;4:234
pubmed: 24065922
Int J Biochem Cell Biol. 2013 May;45(5):932-43
pubmed: 23434541
Biochim Biophys Acta. 2003 Sep 2;1615(1-2):7-32
pubmed: 12948585
Cell Calcium. 1998 Feb-Mar;23(2-3):173-80
pubmed: 9601613
J Am Heart Assoc. 2017 Sep 12;6(9):
pubmed: 28899893
Purinergic Signal. 2018 Dec;14(4):485-497
pubmed: 30417216
Am J Physiol Renal Physiol. 2019 Dec 1;317(6):F1649-F1655
pubmed: 31630543
J Am Soc Nephrol. 2016 Mar;27(3):848-62
pubmed: 26160898
FASEB J. 2020 Apr;34(4):5465-5482
pubmed: 32086866