Functional hyperactivity in long QT syndrome type 1 pluripotent stem cell-derived sympathetic neurons.

Action Potentials / physiology Humans Induced Pluripotent Stem Cells / cytology Leukocytes, Mononuclear / cytology Long QT Syndrome / physiopathology Neurons / physiology Patch-Clamp Techniques Sympathetic Nervous System / physiopathology
arrhythmia mechanisms human induced pluripotent stem cells long QT syndrome sympathetic hyperactivity sympathetic neurons

Journal

American journal of physiology. Heart and circulatory physiology
ISSN: 1522-1539
Titre abrégé: Am J Physiol Heart Circ Physiol
Pays: United States
ID NLM: 100901228

Informations de publication

Date de publication:
01 07 2021
Historique:
pubmed: 19 6 2021
medline: 15 9 2021
entrez: 18 6 2021
Statut: ppublish

Résumé

Sympathetic activation is an established trigger of life-threatening cardiac events in long QT syndrome type 1 (LQT1).

Identifiants

DOI: 10.1152/ajpheart.01002.2020 PMID: 34142889
pubmed: 34142889
doi: 10.1152/ajpheart.01002.2020
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

H217-H227

Auteurs

Annika Winbo (A)

Department of Physiology, University of Auckland, Auckland, New Zealand.
Manaaki Mānawa Centre for Heart Research, University of Auckland, Auckland, New Zealand.
Department of Paediatric and Congenital Cardiac Services, Starship Children's Hospital, Auckland, New Zealand.
The Cardiac Inherited Disease Group (CIDG), Auckland, New Zealand.
Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.
ORCID: 0000-0002-9323-3166

Suganeya Ramanan (S)

Department of Physiology, University of Auckland, Auckland, New Zealand.
Manaaki Mānawa Centre for Heart Research, University of Auckland, Auckland, New Zealand.

Emily Eugster (E)

DeVos Cardiovascular Research Program Spectrum Health/Van Andel Research Institute, Grand Rapids, Michigan.

Annika Rydberg (A)

Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.
ORCID: 0000-0001-9655-7783

Stefan Jovinge (S)

DeVos Cardiovascular Research Program Spectrum Health/Van Andel Research Institute, Grand Rapids, Michigan.
Cardiovascular Institute, Stanford University of Medicine, Stanford, California.

Jonathan R Skinner (JR)

Manaaki Mānawa Centre for Heart Research, University of Auckland, Auckland, New Zealand.
Department of Paediatric and Congenital Cardiac Services, Starship Children's Hospital, Auckland, New Zealand.
The Cardiac Inherited Disease Group (CIDG), Auckland, New Zealand.

Johanna M Montgomery (JM)

Department of Physiology, University of Auckland, Auckland, New Zealand.
Manaaki Mānawa Centre for Heart Research, University of Auckland, Auckland, New Zealand.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Potentiels de membrane › Potentiels d'action › Functional hyperactivity in long QT syndrome...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Functional hyperactivity in long QT syndrome...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches pluripotentes › Cellules souches pluripotentes induites › Functional hyperactivity in long QT syndrome...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Functional hyperactivity in long QT syndrome...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Troubles du rythme cardiaque › Syndrome du QT long › Functional hyperactivity in long QT syndrome...
questionsmedicales.fr › Cellules › Neurones › Functional hyperactivity in long QT syndrome...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Techniques de patch-clamp › Functional hyperactivity in long QT syndrome...
questionsmedicales.fr › Système nerveux › Système nerveux périphérique › Système nerveux autonome › Système nerveux sympathique › Functional hyperactivity in long QT syndrome...