SARS-CoV-2 seroconversions and chains of infection in healthcare professionals in a German maximum care provider (The CoSHeP study).
Chains of infection
Healthcare-professionals
Persisting immunity
SARS-CoV-2-IgG
Journal
Infection
ISSN: 1439-0973
Titre abrégé: Infection
Pays: Germany
ID NLM: 0365307
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
03
03
2021
accepted:
09
06
2021
pubmed:
19
6
2021
medline:
26
11
2021
entrez:
18
6
2021
Statut:
ppublish
Résumé
The CoSHeP study provides novel data on SARS-CoV-2 seroconversion rates in healthcare professionals (HP) at risk at the University Hospital Bonn, a maximum healthcare provider in a region of 900.000 inhabitants. Single-center, longitudinal observational study investigating rate of SARS-CoV-2 IgG seroconversion in HP at 2 time-points. SARS-CoV-2 IgG was measured with Roche Elecsys Anti-SARS-CoV-2 assay. Overall, 150 HP were included. Median age was 35 (range: 19-68). Main operational areas were intensive care unit (53%, n = 80), emergency room (31%, n = 46), and infectious disease department (16%, n = 24). SARS-CoV-2-IgG was detected in 5 participants (3%) at inclusion in May/June 2020, and in another 11 participants at follow-up (December 2020/ January 2021). Of the 16 seropositive participants, 14 had already known their SARS-CoV-2 infection because they had performed a PCR-test previously triggered by symptoms. Trailing chains of infection by self-assessment, 31% (n = 5) of infections were acquired through private contacts, 25% (n = 4) most likely through semi-private contacts during work. 13% (n = 2) were assumed to result through contact with contagious patients, further trailing was unsuccessful in 31% (n = 5). All five participants positive for SARS-CoV-2 IgG at inclusion remained positive with a median of 7 months after infection. Frontline HP caring for hospitalized patients with COVID-19 are at higher risk of SARS-CoV-2 infections. Noteworthy, based upon identified chains of infection most of the infections were acquired in private environment and semi-private contacts during work. The low rate of infection through infectious patients reveals that professional hygiene standards are effective in preventing SARS-CoV-2 infections in HP. Persisting SARS-CoV-2-IgG might indicate longer lasting immunity supporting prioritization of negative HP for vaccination.
Identifiants
pubmed: 34143409
doi: 10.1007/s15010-021-01641-6
pii: 10.1007/s15010-021-01641-6
pmc: PMC8211969
doi:
Substances chimiques
Antibodies, Viral
0
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1039-1043Informations de copyright
© 2021. The Author(s).
Références
Nat Commun. 2020 Jul 8;11(1):3500
pubmed: 32641730
Elife. 2020 Aug 21;9:
pubmed: 32820721
MMWR Morb Mortal Wkly Rep. 2020 Apr 17;69(15):477-481
pubmed: 32298247
N Engl J Med. 2021 Feb 11;384(6):533-540
pubmed: 33369366
J Clin Virol. 2020 Jul;128:104437
pubmed: 32434708
JAMA. 2020 Jul 14;324(2):195-197
pubmed: 32539107
Lancet. 2020 May 2;395(10234):1418-1420
pubmed: 32305073
Nat Commun. 2020 Oct 8;11(1):5064
pubmed: 33033249
Infection. 2020 Aug;48(4):631-634
pubmed: 32524515
Lancet Public Health. 2020 Sep;5(9):e475-e483
pubmed: 32745512