Physico-chemical characterization of bilirubin-10-sulfonate and comparison of its acid-base behavior with unconjugated bilirubin.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
18 06 2021
18 06 2021
Historique:
received:
11
01
2021
accepted:
09
06
2021
entrez:
19
6
2021
pubmed:
20
6
2021
medline:
20
6
2021
Statut:
epublish
Résumé
Unconjugated bilirubin (UCB) is the end-product of heme catabolism in the intravascular compartment. Although beneficial for human health when mildly elevated in the body, when present at greater than a critical threshold concentration, UCB exerts toxic effects that are related to its physico-chemical properties, particularly affecting the central nervous system. The aim of the present study was to characterize bilirubin-10-sulfonate (ranarubin), a naturally occurring bile pigment, including determination of its mixed acidity constants (pK
Identifiants
pubmed: 34145377
doi: 10.1038/s41598-021-92377-8
pii: 10.1038/s41598-021-92377-8
pmc: PMC8213708
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
12896Références
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