Methionine sulfoxide and the methionine sulfoxide reductase system as modulators of signal transduction pathways: a review.
Methionine oxidation
Methionine sulfoxide reductase
Oxidative stress
Posttranslational modification
Journal
Amino acids
ISSN: 1438-2199
Titre abrégé: Amino Acids
Pays: Austria
ID NLM: 9200312
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
22
04
2021
accepted:
14
06
2021
pubmed:
20
6
2021
medline:
22
12
2021
entrez:
19
6
2021
Statut:
ppublish
Résumé
Methionine oxidation and reduction is a common phenomenon occurring in biological systems under both physiological and oxidative-stress conditions. The levels of methionine sulfoxide (MetO) are dependent on the redox status in the cell or organ, and they are usually elevated under oxidative-stress conditions, aging, inflammation, and oxidative-stress related diseases. MetO modification of proteins may alter their function or cause the accumulation of toxic proteins in the cell/organ. Accordingly, the regulation of the level of MetO is mediated through the ubiquitous and evolutionary conserved methionine sulfoxide reductase (Msr) system and its associated redox molecules. Recent published research has provided new evidence for the involvement of free MetO or protein-bound MetO of specific proteins in several signal transduction pathways that are important for cellular function. In the current review, we will focus on the role of MetO in specific signal transduction pathways of various organisms, with relation to their physiological contexts, and discuss the contribution of the Msr system to the regulation of the observed MetO effect.
Identifiants
pubmed: 34145481
doi: 10.1007/s00726-021-03020-9
pii: 10.1007/s00726-021-03020-9
doi:
Substances chimiques
Methionine
AE28F7PNPL
Methionine Sulfoxide Reductases
EC 1.8.4.-
methionine sulfoxide reductase
EC 1.8.4.11
methionine sulfoxide
XN1XVI4B2C
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1011-1020Références
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