Evidence of sulfur mustard poisoning by detection of the albumin-derived dipeptide biomarker C(-HETE)P after nicotinylation.
HETE-moiety
biomarker
chemical warfare agent
protein-adduct
verification
Journal
Drug testing and analysis
ISSN: 1942-7611
Titre abrégé: Drug Test Anal
Pays: England
ID NLM: 101483449
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
revised:
13
06
2021
received:
29
04
2021
accepted:
13
06
2021
pubmed:
20
6
2021
medline:
22
1
2022
entrez:
19
6
2021
Statut:
ppublish
Résumé
Sulfur mustard (SM, bis[2-chloroethyl]-sulfide) is a banned chemical warfare agent that was frequently used in recent years and led to numerous poisoned victims who developed painful erythema and blisters. Post-exposure analysis of SM incorporation can be performed by the detection of human serum albumin (HSA)-derived peptides. HSA alkylated by SM contains a hydroxyethylthioethyl (HETE)-moiety bound to the cysteine residue C
Substances chimiques
Biomarkers
0
Chemical Warfare Agents
0
Dipeptides
0
Niacin
2679MF687A
Mustard Gas
T8KEC9FH9P
Serum Albumin, Human
ZIF514RVZR
Types de publication
Journal Article
Validation Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1593-1602Subventions
Organisme : German Research Foundation
ID : GRK 2338
Informations de copyright
© 2021 The Authors. Drug Testing and Analysis published by John Wiley & Sons Ltd.
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