Indoleamine 2,3-dioxygenase 1 (IDO1): an up-to-date overview of an eclectic immunoregulatory enzyme.
Src kinase
dendritic cells
early endosomes
indoleamine 2,3-dioxygenase 1
moonlighting protein
phosphatidylinositol 3-kinase
tryptophan metabolism
Journal
The FEBS journal
ISSN: 1742-4658
Titre abrégé: FEBS J
Pays: England
ID NLM: 101229646
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
revised:
04
06
2021
received:
12
04
2021
accepted:
18
06
2021
pubmed:
20
6
2021
medline:
20
10
2022
entrez:
19
6
2021
Statut:
ppublish
Résumé
Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the initial rate-limiting step in the degradation of the essential amino acid tryptophan along the kynurenine pathway. When discovered more than 50 years ago, IDO1 was thought to be an effector molecule capable of mediating a survival strategy based on the deprivation of bacteria and tumor cells of the essential amino acid tryptophan. Since 1998, when tryptophan catabolism was discovered to be crucially involved in the maintenance of maternal T-cell tolerance, IDO1 has become the focus of several laboratories around the world. Indeed, IDO1 is now considered as an authentic immune regulator not only in pregnancy, but also in autoimmune diseases, chronic inflammation, and tumor immunity. However, in the last years, a bulk of new information-including structural, biological, and functional evidence-on IDO1 has come to light. For instance, we now know that IDO1 has a peculiar conformational plasticity and, in addition to a complex and highly regulated catalytic activity, is capable of performing a nonenzymic function that reprograms the expression profile of immune cells toward a highly immunoregulatory phenotype. With this state-of-the-art review, we aimed at gathering the most recent information obtained for this eclectic protein as well as at highlighting the major unresolved questions.
Identifiants
pubmed: 34145969
doi: 10.1111/febs.16086
pmc: PMC9786828
doi:
Substances chimiques
Indoleamine-Pyrrole 2,3,-Dioxygenase
0
Kynurenine
343-65-7
Tryptophan
8DUH1N11BX
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6099-6118Informations de copyright
© 2021 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
Références
Nat Rev Mol Cell Biol. 2010 May;11(5):329-41
pubmed: 20379207
FEBS J. 2015 Jul;282(14):2735-45
pubmed: 25950090
Trends Immunol. 2016 Mar;37(3):193-207
pubmed: 26839260
Immunol Rev. 2010 Jul;236:243-64
pubmed: 20636821
Biochim Biophys Acta. 2010 Apr;1803(4):520-5
pubmed: 20144902
Biochim Biophys Acta. 2016 Aug;1863(8):2084-92
pubmed: 27169926
J Biol Chem. 1967 Nov 25;242(22):5260-6
pubmed: 6065097
Nat Commun. 2017 Nov 22;8(1):1693
pubmed: 29167421
Autoimmun Rev. 2019 Apr;18(4):334-348
pubmed: 30797943
Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19961-6
pubmed: 21041655
Clin Cancer Res. 2018 Jun 1;24(11):2559-2573
pubmed: 29500275
Amino Acids. 2014 Oct;46(10):2295-304
pubmed: 25005783
J Immunol. 2005 Nov 1;175(9):5601-5
pubmed: 16237046
J Clin Invest. 2006 Jun;116(6):1571-81
pubmed: 16710471
J Immunol. 2009 Apr 1;182(7):4313-20
pubmed: 19299731
Chem Rev. 1996 Nov 7;96(7):2841-2888
pubmed: 11848843
Int Rev Immunol. 2011 Feb;30(1):16-34
pubmed: 21235323
Metab Brain Dis. 2016 Aug;31(4):737-47
pubmed: 27072164
Cancer Immunol Res. 2020 Jan;8(1):32-45
pubmed: 31806638
Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17615-22
pubmed: 19822761
Infect Immun. 1994 Sep;62(9):3705-11
pubmed: 8063385
Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):13966-71
pubmed: 22891315
Proteins. 2010 Nov 1;78(14):2961-72
pubmed: 20715188
FEBS J. 2020 Oct;287(19):4141-4149
pubmed: 32534477
Front Immunol. 2020 Jun 16;11:1185
pubmed: 32612606
Nat Immunol. 2002 Nov;3(11):1097-101
pubmed: 12368911
Gene. 2007 Jul 1;396(1):203-13
pubmed: 17499941
Nat Rev Immunol. 2007 Oct;7(10):817-23
pubmed: 17767193
J Chem Inf Model. 2009 Apr;49(4):900-12
pubmed: 19292498
Nature. 2019 Feb;566(7745):548-552
pubmed: 30760924
Front Immunol. 2017 Apr 13;8:428
pubmed: 28450863
Immunity. 2005 May;22(5):633-42
pubmed: 15894280
Nat Immunol. 2011 Jul 31;12(9):870-8
pubmed: 21804557
Blood. 2009 Jun 11;113(24):6102-11
pubmed: 19366986
Int J Tryptophan Res. 2017 Oct 09;10:1178646917735098
pubmed: 29051706
Front Immunol. 2020 Aug 18;11:1861
pubmed: 32973768
Front Immunol. 2018 Mar 19;9:575
pubmed: 29616047
FASEB J. 1991 Aug;5(11):2516-22
pubmed: 1907934
Proc Natl Acad Sci U S A. 2016 May 10;113(19):5435-40
pubmed: 27114543
J Exp Med. 2003 Jul 7;198(1):153-60
pubmed: 12835483
Oncoimmunology. 2014 Dec 15;3(10):e957994
pubmed: 25941578
Nat Immunol. 2012 Nov;13(11):1045-1054
pubmed: 23023391
Mutat Res Rev Mutat Res. 2018 Apr - Jun;776:32-45
pubmed: 29807576
ChemMedChem. 2020 May 19;15(10):891-899
pubmed: 32190988
J Neurochem. 2001 Aug;78(4):842-53
pubmed: 11520905
Immunity. 2017 Feb 21;46(2):233-244
pubmed: 28214225
Nat Med. 2005 Mar;11(3):312-9
pubmed: 15711557
Mol Cell Biol. 2002 Jul;22(13):4750-9
pubmed: 12052882
Nature. 2011 Oct 05;478(7368):197-203
pubmed: 21976023
J Immunol. 2017 Mar 1;198(5):1900-1909
pubmed: 28130499
J Immunol. 2009 Aug 15;183(4):2475-83
pubmed: 19635913
Clin Cancer Res. 2019 Mar 1;25(5):1462-1471
pubmed: 30377198
J Immunol. 2001 May 15;166(10):6332-40
pubmed: 11342657
Arch Biochem Biophys. 2015 Mar 15;570:47-57
pubmed: 25712221
PLoS One. 2019 Oct 17;14(10):e0223901
pubmed: 31622420
Curr Opin Immunol. 1997 Jun;9(3):338-43
pubmed: 9203414
J Biol Chem. 1980 Feb 25;255(4):1339-45
pubmed: 7354029
Cell. 2013 Dec 5;155(6):1296-308
pubmed: 24315099
Trends Immunol. 2020 Nov;41(11):1037-1050
pubmed: 33055013
Biochem Pharmacol. 2018 Dec;158:286-297
pubmed: 30391205
Gynecol Oncol. 2009 Nov;115(2):185-92
pubmed: 19665763
Blood. 2007 Feb 1;109(3):1061-8
pubmed: 17008544
J Cell Mol Med. 2017 Jan;21(1):165-176
pubmed: 27696702
Cancer Immunol Res. 2020 Jan;8(1):19-31
pubmed: 31806639
J Am Chem Soc. 2009 Sep 16;131(36):12866-7
pubmed: 19737010
J Am Chem Soc. 2012 Feb 15;134(6):3034-41
pubmed: 22299628
J Cell Biol. 2002 Sep 30;158(7):1239-49
pubmed: 12356868
Clin Cancer Res. 2015 Dec 15;21(24):5427-33
pubmed: 26519060
Nat Commun. 2020 Aug 11;11(1):4011
pubmed: 32782249
Clin Cancer Res. 2006 Feb 15;12(4):1144-51
pubmed: 16489067
Nat Commun. 2013;4:1852
pubmed: 23673637
Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3249-3254
pubmed: 29531094
Trends Mol Med. 2018 Nov;24(11):931-941
pubmed: 30236470
Front Immunol. 2019 Jul 09;10:1565
pubmed: 31354721
Biochemistry. 2005 Nov 1;44(43):14318-28
pubmed: 16245948
Sci Rep. 2017 Mar 03;7:43337
pubmed: 28256612
ChemMedChem. 2019 Dec 17;14(24):2084-2092
pubmed: 31724832
Front Immunol. 2021 Jan 18;11:613069
pubmed: 33584695
Cell. 2017 Aug 10;170(4):605-635
pubmed: 28802037
Blood. 2007 Sep 1;110(5):1540-9
pubmed: 17483297
Hum Immunol. 2013 Feb;74(2):166-9
pubmed: 23200754
Lancet Oncol. 2019 Aug;20(8):1083-1097
pubmed: 31221619
Trends Genet. 2003 Aug;19(8):415-7
pubmed: 12902157
EMBO Rep. 2020 Dec 3;21(12):e49756
pubmed: 33159421
Semin Cell Dev Biol. 2015 Apr;40:134-41
pubmed: 25773161
J Biol Chem. 2013 Jan 18;288(3):1548-67
pubmed: 23209301
J Neurol Sci. 1995 May;130(1):39-47
pubmed: 7650530
Front Immunol. 2015 Jan 12;5:673
pubmed: 25628622
J Immunol. 2006 Jun 1;176(11):6752-61
pubmed: 16709834
PLoS One. 2009 Jul 22;4(7):e6344
pubmed: 19623258
Nat Med. 2007 May;13(5):579-86
pubmed: 17417651
Cancer Immunol Res. 2015 Feb;3(2):161-72
pubmed: 25271151
J Mol Graph Model. 2007 Nov;26(4):728-39
pubmed: 17544772
Expert Opin Drug Discov. 2020 Oct;15(10):1223-1232
pubmed: 32568559
Front Immunol. 2020 May 27;11:839
pubmed: 32536910
Neuroreport. 2003 Dec 19;14(18):2311-5
pubmed: 14663182
J Cell Mol Med. 2015 Jul;19(7):1593-605
pubmed: 25783564
Front Immunol. 2014 Aug 11;5:384
pubmed: 25157255
J Immunol. 2010 Sep 15;185(6):3190-8
pubmed: 20720200
Blood. 2000 Jul 15;96(2):483-90
pubmed: 10887109
J Biol Chem. 2003 Aug 8;278(32):29525-31
pubmed: 12766158
JCI Insight. 2018 Mar 22;3(6):
pubmed: 29563329
Int J Tryptophan Res. 2011;4:29-37
pubmed: 22084601
Cell. 2013 Dec 5;155(6):1209-10
pubmed: 24315090
Acta Crystallogr D Struct Biol. 2020 Dec 1;76(Pt 12):1211-1221
pubmed: 33263327
Trends Microbiol. 2006 Apr;14(4):183-9
pubmed: 16517165
Int J Tryptophan Res. 2010;3:151-6
pubmed: 22084595
J Am Chem Soc. 2021 Feb 3;143(4):1836-1845
pubmed: 33373218
FEBS J. 2021 Dec;288(24):6972-6989
pubmed: 33354925
Cancer Immunol Res. 2017 Aug;5(8):695-709
pubmed: 28765120
Diabetes. 2018 Sep;67(9):1858-1866
pubmed: 29945890
Clin Cancer Res. 2019 Jan 15;25(2):724-734
pubmed: 30266763
Nat Rev Immunol. 2003 Apr;3(4):317-30
pubmed: 12669022
J Cell Mol Med. 2014 Oct;18(10):2082-91
pubmed: 25215657
Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2497-502
pubmed: 22308364
Acta Crystallogr F Struct Biol Commun. 2018 Nov 1;74(Pt 11):717-724
pubmed: 30387777
Neuropharmacology. 2016 Mar;102:59-71
pubmed: 26522434
Front Immunol. 2020 Sep 24;11:531491
pubmed: 33072086
Trends Immunol. 2003 May;24(5):242-8
pubmed: 12738417
J Immunol. 2016 Aug 1;197(3):962-70
pubmed: 27316681
J Reprod Immunol. 2004 Apr;61(2):79-86
pubmed: 15063631
Cancer Res. 2007 Aug 1;67(15):7082-7
pubmed: 17671174
Cell Microbiol. 2013 Jul;15(7):1079-87
pubmed: 23521858
Nat Rev Drug Discov. 2019 May;18(5):379-401
pubmed: 30760888
Mol Med. 2012 Jul 18;18:834-42
pubmed: 22481272
Biochemistry. 2016 May 17;55(19):2785-93
pubmed: 27112409
J Endocrinol. 2013 Dec 02;220(1):73-83
pubmed: 24190896
Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20828-33
pubmed: 19088199
Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2611-6
pubmed: 16477023
Mol Inform. 2016 Sep;35(8-9):449-59
pubmed: 27546049
PLoS One. 2013 Apr 22;8(4):e59749
pubmed: 23630570
J Am Chem Soc. 2018 Jul 11;140(27):8518-8525
pubmed: 29897749
Nat Rev Immunol. 2004 Oct;4(10):762-74
pubmed: 15459668
Sci Rep. 2016 Dec 20;6:39199
pubmed: 27995966
Eur J Immunol. 2007 Apr;37(4):876-9
pubmed: 17393386
Biochim Biophys Acta. 2007 Aug;1774(8):1058-68
pubmed: 17644054
Mol Cell. 2018 Sep 6;71(5):653-673
pubmed: 30193094
Biochemistry. 2019 Feb 19;58(7):974-986
pubmed: 30585477
Eur J Immunol. 2006 Mar;36(3):690-700
pubmed: 16482510
Cell Rep. 2021 Jan 26;34(4):108673
pubmed: 33503414
Sci Adv. 2018 Mar 07;4(3):eaar2766
pubmed: 29532035
Eur J Immunol. 2020 Jul;50(7):944-948
pubmed: 32428262
Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):E62-E71
pubmed: 29255022
J Biol Chem. 1996 Aug 9;271(32):19140-5
pubmed: 8702590
Immunol Rev. 2012 Sep;249(1):158-75
pubmed: 22889221
J Autoimmun. 2020 Dec;115:102509
pubmed: 32605792
J Immunol. 2017 Apr 1;198(7):2957-2966
pubmed: 28242650
Cancer Res. 2017 Dec 15;77(24):6795-6811
pubmed: 29247038
Science. 1998 Aug 21;281(5380):1191-3
pubmed: 9712583
Nature. 2014 Jul 10;511(7508):184-90
pubmed: 24930766
Front Immunol. 2021 Apr 21;12:679953
pubmed: 33968089
Int Immunol. 2014 Jul;26(7):357-67
pubmed: 24402311
Mol Brain. 2009 Mar 27;2:8
pubmed: 19323847
Proc Natl Acad Sci U S A. 2020 Feb 18;117(7):3848-3857
pubmed: 32024760
J Med Chem. 2011 Aug 11;54(15):5320-34
pubmed: 21726069
Parkinsons Dis. 2011;2011:716859
pubmed: 21687761
Nat Immunol. 2011 Aug 18;12(9):809-11
pubmed: 21852775
Oncotarget. 2014 Feb 28;5(4):1038-51
pubmed: 24657910
Biomed Pharmacother. 2021 May;137:111295
pubmed: 33550042
Front Immunol. 2015 Feb 03;6:34
pubmed: 25691885
Nat Immunol. 2003 Dec;4(12):1206-12
pubmed: 14578884
Biochemistry. 2010 Jun 22;49(24):5028-34
pubmed: 20476772
J Am Coll Surg. 2009 May;208(5):781-7; discussion 787-9
pubmed: 19476837
Cell Transplant. 2018 Nov;27(11):1657-1683
pubmed: 30311501
Int J Tryptophan Res. 2016 Oct 12;9:67-77
pubmed: 27773992
Front Immunol. 2020 Mar 11;11:292
pubmed: 32226425
Front Immunol. 2014 Dec 15;5:640
pubmed: 25566253
J Mol Evol. 2007 Dec;65(6):705-14
pubmed: 18026683
Front Immunol. 2019 Aug 20;10:1973
pubmed: 31481962
Diabetes. 2014 Nov;63(11):3835-45
pubmed: 24939426
Front Immunol. 2019 Mar 19;10:453
pubmed: 30941125