Osmotic hemolysis is a donor-specific feature of red blood cells under various storage conditions and genetic backgrounds.
RBC Transfusion
blood component preparations
donors
Journal
Transfusion
ISSN: 1537-2995
Titre abrégé: Transfusion
Pays: United States
ID NLM: 0417360
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
revised:
23
04
2021
received:
25
02
2021
accepted:
20
05
2021
pubmed:
20
6
2021
medline:
9
11
2021
entrez:
19
6
2021
Statut:
ppublish
Résumé
Transfusion research has recently focused on the discovery of red blood cell (RBC) storage capacity biomarkers and the elucidation of donor variation effects. This shift of focus can further strengthen personalization of transfusion therapy, by revealing probable links between donor biology, RBC storage lesion profile, and posttransfusion performance. We performed a paired correlation analysis of osmotic fragility in freshly drawn RBCs and during cold storage in different preservative solutions at weekly intervals until unit's expiration date (n = 231), or following 24 h reconstitution in allogeneic plasma (n = 32) from healthy controls or transfusion-dependent beta-thalassemia patients. We observed exceptional correlation profiles (r > 0.700, p < 10 Our findings highlighted the potential of osmotic fragility to serve as a donor-signature on RBCs at every step of any individual transfusion chain (donor, blood product, and probably, recipient).
Sections du résumé
BACKGROUND
Transfusion research has recently focused on the discovery of red blood cell (RBC) storage capacity biomarkers and the elucidation of donor variation effects. This shift of focus can further strengthen personalization of transfusion therapy, by revealing probable links between donor biology, RBC storage lesion profile, and posttransfusion performance.
STUDY DESIGN AND METHODS
We performed a paired correlation analysis of osmotic fragility in freshly drawn RBCs and during cold storage in different preservative solutions at weekly intervals until unit's expiration date (n = 231), or following 24 h reconstitution in allogeneic plasma (n = 32) from healthy controls or transfusion-dependent beta-thalassemia patients.
RESULTS
We observed exceptional correlation profiles (r > 0.700, p < 10
CONCLUSION
Our findings highlighted the potential of osmotic fragility to serve as a donor-signature on RBCs at every step of any individual transfusion chain (donor, blood product, and probably, recipient).
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2538-2544Informations de copyright
© 2021 AABB.
Références
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