Synthesis of hapten, production of monoclonal antibody, and development of immunoassay for ribavirin detection in chicken.

Animals Antibodies, Monoclonal / immunology Chickens / metabolism Enzyme-Linked Immunosorbent Assay / methods Female Haptens / biosynthesis Mice Mice, Inbred BALB C Ribavirin / analysis
chicken computational chemistry haptens monoclonal antibody ribavirin

Journal

Journal of food science
ISSN: 1750-3841
Titre abrégé: J Food Sci
Pays: United States
ID NLM: 0014052

Informations de publication

Date de publication:
Jul 2021
Historique:
revised: 08 04 2021
received: 02 02 2021
accepted: 27 04 2021
pubmed: 20 6 2021
medline: 20 7 2021
entrez: 19 6 2021
Statut: ppublish

Résumé

Ribavirin (RBV) is an effective antiviral drug, whose use is prohibited in animal husbandry worldwide. In this work, a novel immunizing hapten of RBV, named Hapten 4, was designed by comparing the conformational and electronic properties of RBV and haptens based on computational chemistry. Hapten 4 was synthesized and conjugated with carrier proteins to produce monoclonal antibody (mAb). The obtained mAb 4C3 for RBV exhibited an IC

Identifiants

DOI: 10.1111/1750-3841.15789 PMID: 34146404
pubmed: 34146404
doi: 10.1111/1750-3841.15789
doi:

Substances chimiques

Antibodies, Monoclonal 0
Haptens 0
Ribavirin 49717AWG6K

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2851-2860

Informations de copyright

© 2021 Institute of Food Technologists®.

Références

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Auteurs

Jianyu Zhu (J)

College of Veterinary Medicine, Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety Beijing Laboratory for Food Quality and Safety, China Agricultural University, Beijing, People's Republic of China.

Qiang Li (Q)

College of Veterinary Medicine, Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety Beijing Laboratory for Food Quality and Safety, China Agricultural University, Beijing, People's Republic of China.

Xuezhi Yu (X)

College of Veterinary Medicine, Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety Beijing Laboratory for Food Quality and Safety, China Agricultural University, Beijing, People's Republic of China.

Xiya Zhang (X)

Henan Province Engineering Research Center for Food Safety Control of Processing and Circulation, College of Food Science and Technology, Henan Agricultural University, Zhengzhou, Henan, People's Republic of China.

Hongfang Li (H)

College of Veterinary Medicine, Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety Beijing Laboratory for Food Quality and Safety, China Agricultural University, Beijing, People's Republic of China.

Kai Wen (K)

College of Veterinary Medicine, Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety Beijing Laboratory for Food Quality and Safety, China Agricultural University, Beijing, People's Republic of China.
ORCID: 0000-0002-9553-259X

Yuebin Ke (Y)

Department of Genetic Toxicology, Shenzhen Center for Disease Control and Prevention, People's Republic of China.

Suxia Zhang (S)

College of Veterinary Medicine, Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety Beijing Laboratory for Food Quality and Safety, China Agricultural University, Beijing, People's Republic of China.

Zhanhui Wang (Z)

College of Veterinary Medicine, Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety Beijing Laboratory for Food Quality and Safety, China Agricultural University, Beijing, People's Republic of China.
ORCID: 0000-0002-0167-9559

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Synthesis of hapten, production of monoclonal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Synthesis of hapten, production of monoclonal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Oiseaux › Poulets › Synthesis of hapten, production of monoclonal...
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Dosage immunologique › Techniques d'immunoadsorption › Test ELISA › Synthesis of hapten, production of monoclonal...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Épitopes › Haptènes › Synthesis of hapten, production of monoclonal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Synthesis of hapten, production of monoclonal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Synthesis of hapten, production of monoclonal...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Ribavirine › Synthesis of hapten, production of monoclonal...