A cerebellar-thalamocortical pathway drives behavioral context-dependent movement initiation.
2-photon imaging
behavioural context
cerebellar nuclei
cerebellar thalamocortical pathway
in vivo patch-clamp
motor cortex
motor thalamus
motor timing
movement initiation
photoactivation
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
21 07 2021
21 07 2021
Historique:
received:
23
09
2019
revised:
07
04
2021
accepted:
11
05
2021
pubmed:
20
6
2021
medline:
10
8
2021
entrez:
19
6
2021
Statut:
ppublish
Résumé
Executing learned motor behaviors often requires the transformation of sensory cues into patterns of motor commands that generate appropriately timed actions. The cerebellum and thalamus are two key areas involved in shaping cortical output and movement, but the contribution of a cerebellar-thalamocortical pathway to voluntary movement initiation remains poorly understood. Here, we investigated how an auditory "go cue" transforms thalamocortical activity patterns and how these changes relate to movement initiation. Population responses in dentate/interpositus-recipient regions of motor thalamus reflect a time-locked increase in activity immediately prior to movement initiation that is temporally uncoupled from the go cue, indicative of a fixed-latency feedforward motor timing signal. Blocking cerebellar or motor thalamic output suppresses movement initiation, while stimulation triggers movements in a behavioral context-dependent manner. Our findings show how cerebellar output, via the thalamus, shapes cortical activity patterns necessary for learned context-dependent movement initiation.
Identifiants
pubmed: 34146469
pii: S0896-6273(21)00356-1
doi: 10.1016/j.neuron.2021.05.016
pmc: PMC8315304
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2326-2338.e8Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/R018537/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 110131/Z/15/Z
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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