Enzyme-free impedimetric biosensor-based molecularly imprinted polymer for selective determination of L-hydroxyproline.
Bone diseases
Electrochemical impedance spectroscopy
L-hydroxyproline
Molecularly imprinted polymer
Non-enzymatic sensor
Journal
Biosensors & bioelectronics
ISSN: 1873-4235
Titre abrégé: Biosens Bioelectron
Pays: England
ID NLM: 9001289
Informations de publication
Date de publication:
01 Nov 2021
01 Nov 2021
Historique:
received:
21
04
2021
revised:
25
05
2021
accepted:
28
05
2021
pubmed:
20
6
2021
medline:
20
8
2021
entrez:
19
6
2021
Statut:
ppublish
Résumé
This study first reported enzyme-free impedimetric biosensor-based molecularly imprinted polymers for selective and sensitive determination of L-hydroxyproline (L-hyp), a biomarker for the early diagnosis of bone diseases. In recent study, utilizing a single 3-aminophenylboronic acid (3-APBA) to create imprinted surfaces could result in a strong interaction and difficulty in removal of a template molecule. Hence, a mixture of monomer solution containing 3-APBA and o-phenylenediamine (OPD) in the presence of the L-hyp molecule was co-electropolymerized onto the screen-printed electrode using cyclic voltammetry (CV) to eradicate this mentioned limitation. The detection principle of this sensor is relied on alteration of mediator's charge transfer resistance (R
Identifiants
pubmed: 34146970
pii: S0956-5663(21)00424-3
doi: 10.1016/j.bios.2021.113387
pii:
doi:
Substances chimiques
Molecularly Imprinted Polymers
0
Hydroxyproline
RMB44WO89X
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113387Informations de copyright
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