Thalamo-cortical networks in subtypes of migraine with aura patients.
aura
diffusion tensor imaging
migraine
networks
resting state
thalamus
Journal
The journal of headache and pain
ISSN: 1129-2377
Titre abrégé: J Headache Pain
Pays: England
ID NLM: 100940562
Informations de publication
Date de publication:
19 Jun 2021
19 Jun 2021
Historique:
received:
26
04
2021
accepted:
01
06
2021
entrez:
20
6
2021
pubmed:
21
6
2021
medline:
23
6
2021
Statut:
epublish
Résumé
We searched for differences in resting-state functional connectivity (FC) between brain networks and its relationship with the microstructure of the thalamus between migraine with pure visual auras (MA), and migraine with complex neurological auras (MA+), i.e. with the addition of at least one of sensory or language symptom. 3T MRI data were obtained from 20 patients with MA and 15 with MA + and compared with those from 19 healthy controls (HCs). We collected resting state data among independent component networks. Diffusivity metrics of bilateral thalami were calculated and correlated with resting state ICs-Z-scores. As compared to HCs, both patients with MA and MA + disclosed disrupted FC between the default mode network (DMN) and the right dorsal attention system (DAS). The MA + subgroup had lower microstructural metrics than both HCs and the MA subgroup, which correlated negatively with the strength of DMN connectivity. Although the microstructural metrics of MA patients did not differ from those of HCs, these patients lacked the correlation with the strength of DAS connectivity found in HCs. The present findings suggest that, as far as MRI profiles are concerned, the two clinical phenotypes of migraine with aura have both common and distinct morpho-functional features of nodes in the thalamo-cortical network.
Sections du résumé
BACKGROUND
BACKGROUND
We searched for differences in resting-state functional connectivity (FC) between brain networks and its relationship with the microstructure of the thalamus between migraine with pure visual auras (MA), and migraine with complex neurological auras (MA+), i.e. with the addition of at least one of sensory or language symptom.
METHODS
METHODS
3T MRI data were obtained from 20 patients with MA and 15 with MA + and compared with those from 19 healthy controls (HCs). We collected resting state data among independent component networks. Diffusivity metrics of bilateral thalami were calculated and correlated with resting state ICs-Z-scores.
RESULTS
RESULTS
As compared to HCs, both patients with MA and MA + disclosed disrupted FC between the default mode network (DMN) and the right dorsal attention system (DAS). The MA + subgroup had lower microstructural metrics than both HCs and the MA subgroup, which correlated negatively with the strength of DMN connectivity. Although the microstructural metrics of MA patients did not differ from those of HCs, these patients lacked the correlation with the strength of DAS connectivity found in HCs.
CONCLUSIONS
CONCLUSIONS
The present findings suggest that, as far as MRI profiles are concerned, the two clinical phenotypes of migraine with aura have both common and distinct morpho-functional features of nodes in the thalamo-cortical network.
Identifiants
pubmed: 34147064
doi: 10.1186/s10194-021-01272-0
pii: 10.1186/s10194-021-01272-0
pmc: PMC8214259
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
58Subventions
Organisme : Italian Ministry of Health
ID : Italian Ministry of Health
Organisme : Fondazione Roma
ID : Fondazione Roma
Références
Cephalalgia. 2018 Jan;38(1):1-211
pubmed: 29368949
Front Neuroinform. 2012 Mar 27;6:10
pubmed: 22470337
Neuroimage. 2008 Feb 15;39(4):1666-81
pubmed: 18082428
Pain. 2020 Apr;161(4):856-864
pubmed: 31815918
Neural Comput. 1995 Nov;7(6):1129-59
pubmed: 7584893
Front Neuroanat. 2018 Jan 17;11:138
pubmed: 29387002
Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9673-8
pubmed: 15976020
Hum Brain Mapp. 2014 Apr;35(4):1461-8
pubmed: 23450507
J Neurol. 2020 Jan;267(1):185-191
pubmed: 31606759
Brain. 2007 Dec;130(Pt 12):3102-10
pubmed: 17956910
J Headache Pain. 2015;16:92
pubmed: 26527348
NMR Biomed. 2002 Nov-Dec;15(7-8):435-55
pubmed: 12489094
J Headache Pain. 2017 Dec;18(1):8
pubmed: 28124204
Nat Rev Neurosci. 2002 Mar;3(3):201-15
pubmed: 11994752
Cephalalgia. 2008 Oct;28(10):1061-8
pubmed: 18644035
Brain. 2011 Aug;134(Pt 8):2387-95
pubmed: 21729907
Hum Brain Mapp. 1998;6(3):160-88
pubmed: 9673671
Neuroimage. 2017 Jul 1;154:188-205
pubmed: 27989777
Neurology. 2016 Nov 15;87(20):2154-2160
pubmed: 27742813
Neuroreport. 2007 Mar 5;18(4):301-5
pubmed: 17435592
J Cogn Neurosci. 2013 Jan;25(1):74-86
pubmed: 22905821
Eur J Neurol. 2015 Apr;22(4):702-e46
pubmed: 25573335
PLoS Med. 2006 Oct;3(10):e402
pubmed: 17048979
Front Neurol. 2019 Oct 18;10:1112
pubmed: 31681162
Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):676-82
pubmed: 11209064
J Stroke Cerebrovasc Dis. 2018 May;27(5):1262-1266
pubmed: 29331612
Front Neurol. 2019 Oct 01;10:1039
pubmed: 31632336
Philos Trans R Soc Lond B Biol Sci. 2005 May 29;360(1457):1001-13
pubmed: 16087444
Neurology. 2019 May 28;92(22):e2550-e2558
pubmed: 31053665
J Headache Pain. 2016 Dec;17(1):100
pubmed: 27778244
Neuroimage Clin. 2017 Jul 22;16:196-204
pubmed: 28794980
Neurosci Lett. 1999 Dec 10;276(3):201-3
pubmed: 10612640
Headache. 2006 Feb;46(2):286-97
pubmed: 16492238
AJNR Am J Neuroradiol. 2012 Sep;33(8):1546-52
pubmed: 22517281
Brain Struct Funct. 2016 May;221(4):1971-84
pubmed: 25924563
Neuroscientist. 2014 Apr;20(2):150-9
pubmed: 23835449
Hum Brain Mapp. 2017 May;38(5):2635-2642
pubmed: 28240389
Cephalalgia. 2016 Feb;36(2):139-47
pubmed: 25926619
Cephalalgia. 2017 Sep;37(10):979-989
pubmed: 27573009
Trends Cogn Sci. 2020 Apr;24(4):302-315
pubmed: 32160567
Curr Opin Neurobiol. 2007 Aug;17(4):417-22
pubmed: 17707635
Cephalalgia. 2014 Oct;34(11):870-6
pubmed: 24554619
Cephalalgia. 2005 Jul;25(7):507-18
pubmed: 15955037
Cereb Cortex. 2021 Jun 10;31(7):3213-3225
pubmed: 33667310
PLoS One. 2008;3(11):e3631
pubmed: 18982065
J Neurosci. 2011 Apr 13;31(15):5755-63
pubmed: 21490217
Eur J Neurosci. 2015 Jan;41(1):120-8
pubmed: 25327971