IFN-β Acts on Monocytes to Ameliorate CNS Autoimmunity by Inhibiting Proinflammatory Cross-Talk Between Monocytes and Th Cells.
Animals
Antigen-Presenting Cells
/ immunology
Autoimmunity
/ drug effects
Cell Communication
/ genetics
Cytokines
/ metabolism
Disease Models, Animal
Disease Susceptibility
/ immunology
Encephalomyelitis, Autoimmune, Experimental
/ etiology
Granulocyte-Macrophage Colony-Stimulating Factor
/ biosynthesis
Interferon-beta
/ metabolism
Mice
Mice, Knockout
Monocytes
/ drug effects
T-Lymphocytes, Helper-Inducer
/ drug effects
EAE
GM-CSF
IFN-β
Th cells
monocytes
multiple sclerosis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
11
03
2021
accepted:
12
05
2021
entrez:
21
6
2021
pubmed:
22
6
2021
medline:
30
10
2021
Statut:
epublish
Résumé
IFN-β has been the treatment for multiple sclerosis (MS) for almost three decades, but understanding the mechanisms underlying its beneficial effects remains incomplete. We have shown that MS patients have increased numbers of GM-CSF
Identifiants
pubmed: 34149716
doi: 10.3389/fimmu.2021.679498
pmc: PMC8213026
doi:
Substances chimiques
Cytokines
0
Interferon-beta
77238-31-4
Granulocyte-Macrophage Colony-Stimulating Factor
83869-56-1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
679498Subventions
Organisme : NCI NIH HHS
ID : P30 CA056036
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI124386
Pays : United States
Informations de copyright
Copyright © 2021 Rasouli, Casella, Ishikawa, Thome, Boehm, Ertel, Melo-Silva, Mari, Porazzi, Zhang, Xiao, Sigal, Fortina, Zhang, Rostami and Ciric.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Brain Behav Immun. 2011 Aug;25(6):1170-81
pubmed: 21420486
Bioinformatics. 2011 Jun 15;27(12):1739-40
pubmed: 21546393
J Clin Invest. 2008 May;118(5):1680-90
pubmed: 18382764
Eur J Immunol. 1999 Mar;29(3):774-80
pubmed: 10092079
Nat Immunol. 2020 Jan;21(1):65-74
pubmed: 31848486
J Immunol. 2008 May 15;180(10):6457-61
pubmed: 18453561
Nat Commun. 2014 Oct 03;5:5056
pubmed: 25278028
Nat Med. 2010 Apr;16(4):406-12
pubmed: 20348925
J Exp Med. 2016 May 30;213(6):929-49
pubmed: 27139491
Immunity. 2006 Feb;24(2):179-89
pubmed: 16473830
Immunity. 2015 Dec 15;43(6):1148-59
pubmed: 26682986
J Immunol. 2015 Jun 1;194(11):5085-93
pubmed: 25917097
Mult Scler. 2008 Mar;14(2):166-76
pubmed: 17942524
Sci Immunol. 2017 Oct 6;2(16):
pubmed: 28986418
Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14116-21
pubmed: 22893686
Neurology. 1993 Apr;43(4):655-61
pubmed: 8469318
J Neuropathol Exp Neurol. 2006 Feb;65(2):124-41
pubmed: 16462204
Blood. 1998 Feb 1;91(3):1037-43
pubmed: 9446667
J Biol Chem. 2014 Oct 17;289(42):29014-29
pubmed: 25193661
Immunity. 2015 Sep 15;43(3):502-14
pubmed: 26341401
J Neuroinflammation. 2016 Jun 07;13(1):139
pubmed: 27266518
J Clin Invest. 1991 Mar;87(3):986-95
pubmed: 1705569
Sci Immunol. 2020 Oct 23;5(52):
pubmed: 33097590
Immunity. 2011 Feb 25;34(2):213-23
pubmed: 21349431
Proc Natl Acad Sci U S A. 1988 Dec;85(23):9253-7
pubmed: 3057504
J Exp Med. 2001 Oct 1;194(7):873-82
pubmed: 11581310
Science. 2017 Apr 21;356(6335):
pubmed: 28428369
J Immunol. 2007 Jan 1;178(1):39-48
pubmed: 17182538
Nature. 1989 Feb 2;337(6206):471-3
pubmed: 2464767
J Immunol. 2014 Oct 1;193(7):3600-12
pubmed: 25187652
Neurology. 2014 Jul 15;83(3):278-86
pubmed: 24871874
Nat Immunol. 2007 Dec;8(12):1372-9
pubmed: 17994023
Acta Neuropathol Commun. 2015 Apr 03;3:20
pubmed: 25853624
Blood. 1989 Mar;73(4):1033-7
pubmed: 2537665
J Autoimmun. 2017 Nov;84:1-11
pubmed: 28641926
Sci Immunol. 2019 Jan 25;4(31):
pubmed: 30679199
Trends Immunol. 2015 Oct;36(10):651-662
pubmed: 26431942
Front Immunol. 2019 Apr 12;10:778
pubmed: 31031767
Nature. 2005 Apr 21;434(7036):1035-40
pubmed: 15815647
EBioMedicine. 2019 Nov;49:269-283
pubmed: 31648992
J Neurol. 2005 Sep;252 Suppl 3:iii3-iii9
pubmed: 16170498
Nat Immunol. 2011 Jun;12(6):568-75
pubmed: 21516111
Clin Immunol. 2000 May;95(2):117-23
pubmed: 10779405
J Immunol. 1997 Oct 1;159(7):3100-3
pubmed: 9317104
Nat Immunol. 2018 Jul;19(7):711-722
pubmed: 29925996
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Sci Transl Med. 2014 Jun 18;6(241):241ra80
pubmed: 24944195
Arthritis Res. 2002;4(6):346-52
pubmed: 12453310
J Neuroimmunol. 2018 Apr 15;317:45-54
pubmed: 29290406
J Immunol. 1997 Oct 1;159(7):3096-9
pubmed: 9317103
J Exp Med. 2000 Oct 2;192(7):1075-80
pubmed: 11015448
J Clin Invest. 2018 Dec 3;128(12):5322-5334
pubmed: 30226829
J Immunol. 2011 Dec 1;187(11):5660-70
pubmed: 22058414
Nat Rev Immunol. 2015 Feb;15(2):87-103
pubmed: 25614319
Immunity. 2008 May;28(5):675-86
pubmed: 18424188
J Autoimmun. 2016 Feb;67:8-18
pubmed: 26341385
J Immunol. 2013 Apr 1;190(7):3225-34
pubmed: 23455508
J Clin Invest. 1997 Nov 15;100(10):2552-61
pubmed: 9366570
Nat Rev Immunol. 2014 Jan;14(1):36-49
pubmed: 24362405
Trends Immunol. 2011 Jun;32(6):272-7
pubmed: 21530402
J Immunol. 2012 Sep 1;189(5):2079-83
pubmed: 22837488
Nat Immunol. 2006 Nov;7(11):1151-6
pubmed: 16998492
Neurology. 2007 Jun 12;68(24 Suppl 4):S8-11
pubmed: 17562848
Nat Immunol. 2020 May;21(5):525-534
pubmed: 32313246
Neurol Neuroimmunol Neuroinflamm. 2015 May 21;2(4):e117
pubmed: 26185773
Nat Immunol. 2011 Jun;12(6):560-7
pubmed: 21516112
Nat Immunol. 2007 Dec;8(12):1380-9
pubmed: 17994022
Front Immunol. 2017 Oct 27;8:1392
pubmed: 29163476
Ann Neurol. 2004 May;55(5):627-38
pubmed: 15122702
Annu Rev Immunol. 2009;27:519-50
pubmed: 19302047
Nat Med. 2019 Aug;25(8):1290-1300
pubmed: 31332391
J Neuroimmunol. 2004 Oct;155(1-2):172-82
pubmed: 15342209