Comparison of proteolytic, cytotoxic and anticoagulant properties of chromatographically fractionated bromelain to un-fractionated bromelain.

Bromelain cancer coagulation cytotoxic proteolysis

Journal

American journal of translational research
ISSN: 1943-8141
Titre abrégé: Am J Transl Res
Pays: United States
ID NLM: 101493030

Informations de publication

Date de publication:
2021
Historique:
received: 12 10 2020
accepted: 02 03 2021
entrez: 21 6 2021
pubmed: 22 6 2021
medline: 22 6 2021
Statut: epublish

Résumé

Bromelain consisting of a number of proteolytic enzymes possess anticancer and thrombotic properties. Hence, four chromatically separated fractions were examined for their proteolytic, anticancer and antithrombotic activity. Bromelain fractions were separated using ion-exchange column chromatography. Proteolytic properties were assessed using standard azocasein assay. Anticancer properties were first assessed using four different cell lines PANC-1, HEP 2B, HEP 3G and OVCAR-3 on cells grown in 96 well plates. Subsequently, fraction 2 and fraction 3 combined with gemcitabine were tested in ASPC-1 cells. Then cytotoxicity of fraction 3 was compared to bromelain in combination with doxorubicin and N-acetylcysteine on HEP G2 and HEP 3B cells. Finally, the anticoagulation effect of fraction 3 or bromelain combined with N-acetylcysteine was evaluated using human blood. Fraction 3 showed the highest proteolytic activity (5% greater than standard bromelain) whilst others were less active. Cytotoxicity as assessed by IC50 indicated fraction 3 to be the most potent whilst the others did not follow their proteolytic potency order. OVCAR-3 was the most sensitive amongst the cell lines. Fraction 3 showed higher potency in combination with gemcitabine in ASPC-1 cells compared to fraction 2. Similarly, fraction 3 in combination with doxorubicin showed higher toxicity when compared to bromelain. Fraction 3 or bromelain only showed thrombolytic activity in combination with N-acetylcysteine. Fraction 3 may be developed for clinical use since it showed better cytotoxicity compared to bromelain.

Identifiants

pubmed: 34150016
pmc: PMC8205729

Types de publication

Journal Article

Langues

eng

Pagination

4309-4321

Informations de copyright

AJTR Copyright © 2021.

Déclaration de conflit d'intérêts

None.

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Auteurs

Samina Badar (S)

Department of Surgery, University of New South Wales, St. George Hospital Kogarah, NSW, Australia.

Mohamed Azarkan (M)

Service de Chimie Générale I (CP 609), Protein Chemistry Unit, Faculty of Medicine, Université Libre de Bruxelles (ULB) Brussels, Belgium.

Ahmed H Mekkawy (AH)

Department of Surgery, University of New South Wales, St. George Hospital Kogarah, NSW, Australia.
Mucpharm Pty Ltd Australia.

Javed Akhter (J)

Department of Surgery, University of New South Wales, St. George Hospital Kogarah, NSW, Australia.
Mucpharm Pty Ltd Australia.

Krishna Pillai (K)

Department of Surgery, University of New South Wales, St. George Hospital Kogarah, NSW, Australia.
Mucpharm Pty Ltd Australia.

Rachida El Mahyaoui (R)

Service de Chimie Générale I (CP 609), Protein Chemistry Unit, Faculty of Medicine, Université Libre de Bruxelles (ULB) Brussels, Belgium.

Kevin Ke (K)

Department of Surgery, University of New South Wales, St. George Hospital Kogarah, NSW, Australia.

Lauren Cavanaugh (L)

Haematology Department, St. George Hospital Kogarah, NSW, Australia.

David L Morris (DL)

Department of Surgery, University of New South Wales, St. George Hospital Kogarah, NSW, Australia.
Mucpharm Pty Ltd Australia.

Classifications MeSH