Distal chromosome 1q aberrations and initial response to ibrutinib in central nervous system relapsed mantle cell lymphoma.
Central nervous system relapse
Chromosome 1 aberration
Copy number alteration
Ibrutinib response
Mantle cell lymphoma
Journal
Leukemia research reports
ISSN: 2213-0489
Titre abrégé: Leuk Res Rep
Pays: England
ID NLM: 101608906
Informations de publication
Date de publication:
2021
2021
Historique:
received:
05
01
2021
revised:
14
05
2021
accepted:
23
05
2021
entrez:
21
6
2021
pubmed:
22
6
2021
medline:
22
6
2021
Statut:
epublish
Résumé
Relapse involving the central nervous system (CNS) is an infrequent event in the progression of mantle cell lymphoma (MCL) with an incidence of approximately four percent. We report four cases of MCL with CNS relapse. In three of the four patients a large chromosomal copy-number alteration (CNA) of 1q was demonstrated together with TP53 mutation/deletion. These patients experienced brief response to ibrutinib, whereas a fourth patient harboring mutated ATM demonstrated a long-term effect to ibrutinib and no CNA. Although it is unclear whether chromosome 1q CNA contribute to specific phenotypes these reports may be of value as such lesions are uncommon features of MCL.
Identifiants
pubmed: 34150491
doi: 10.1016/j.lrr.2021.100255
pii: S2213-0489(21)00022-4
pmc: PMC8190481
doi:
Types de publication
Case Reports
Langues
eng
Pagination
100255Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2021 The Author(s). Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
The authors have nothing to disclose.
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