Utilization of Intravenous Lidocaine Infusion for the Treatment of Refractory Chronic Pain.
CRPS
Chronic Pain
Fibromyalgia
Headache
Lidocaine
Low Back Pain
Journal
Anesthesiology and pain medicine
ISSN: 2228-7523
Titre abrégé: Anesth Pain Med
Pays: Netherlands
ID NLM: 101585412
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
19
12
2020
accepted:
21
12
2020
entrez:
21
6
2021
pubmed:
22
6
2021
medline:
22
6
2021
Statut:
epublish
Résumé
Chronic pain accounts for one of the most common reasons patients seek medical care. The financial burden of chronic pain on health care is seen by direct financial cost and resource utilization. Many risk factors may contribute to chronic pain, but there is no definite risk. Managing chronic pain is a balance between maximally alleviating symptoms by utilizing a therapeutic regimen that is safe for long-term use. Currently, non-opioid analgesics, NSAIDs, and opioids are some of the medical treatment options, but these have numerous adverse effects and may not be the best option for long-term use. However, Lidocaine can achieve both central and peripheral analgesic effects with relatively few side effects, which may be an ideal compound for managing chronic pain. This is a Narrative Review. Infusion of lidocaine (2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide), an amino-amide compound, is emerging as a promising option to fill the therapeutic void for treatment of chronic pain. Numerous studies have outlined dosing protocols for lidocaine infusion for the management of perioperative pain, outlined below. While there are slight variations in these different protocols, they all center around a similar dosing regimen to administer a bolus to reach a rapid steady state, followed by infusion for up to 72 hours to maintain the therapeutic analgesic effects. Lidocaine may be a promising pharmacologic solution with a low side effect profile that provides central and peripheral analgesia. Even though the multifaceted mechanism is not entirely understood yet, lidocaine may be a promising novel remedy in treating chronic pain in various conditions.
Identifiants
pubmed: 34150583
doi: 10.5812/aapm.112290
pmc: PMC8207879
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
e112290Informations de copyright
Copyright © 2020, Author(s).
Déclaration de conflit d'intérêts
Conflict of Interests: None declared.
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