Nanoparticle-Based Therapies for Turning Cold Tumors Hot: How to Treat an Immunosuppressive Tumor Microenvironment.
cancer therapies
cold tumors
drug delivery
hot tumors
immunotherapies
nanoparticles
nanotechnologies
tumor immune microenvironment
Journal
Frontiers in bioengineering and biotechnology
ISSN: 2296-4185
Titre abrégé: Front Bioeng Biotechnol
Pays: Switzerland
ID NLM: 101632513
Informations de publication
Date de publication:
2021
2021
Historique:
received:
31
03
2021
accepted:
10
05
2021
entrez:
21
6
2021
pubmed:
22
6
2021
medline:
22
6
2021
Statut:
epublish
Résumé
Nanotechnologies are rapidly increasing their role in immuno-oncology in line with the need for novel therapeutic strategies to treat patients unresponsive to chemotherapies and immunotherapies. The tumor immune microenvironment (TIME) has emerged as critical for tumor classification and patient stratification to design better treatments. Notably, the tumor infiltration of effector T cells plays a crucial role in antitumor responses and has been identified as the primary parameter to define hot, immunosuppressed, excluded, and cold tumors. Organic and inorganic nanoparticles (NPs) have been applied as carriers of new targeted therapies to turn cold or altered (i.e., immunosuppressed or excluded) tumors into more therapeutically responsive hot tumors. This mini-review discusses the significant advances in NP-based approaches to turn immunologically cold tumors into hot ones.
Identifiants
pubmed: 34150739
doi: 10.3389/fbioe.2021.689245
pmc: PMC8207137
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
689245Informations de copyright
Copyright © 2021 Giustarini, Pavesi and Adriani.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Pharmaceutics. 2020 Mar 25;12(4):
pubmed: 32218326
Oncoimmunology. 2020 Jul 21;9(1):1796002
pubmed: 32934889
Nano Lett. 2019 May 8;19(5):2774-2783
pubmed: 30943039
ACS Nano. 2011 Dec 27;5(12):9648-57
pubmed: 22111911
Lab Invest. 2020 Apr;100(4):606-618
pubmed: 31857701
Vaccine. 2010 Feb 3;28(5):1383-90
pubmed: 19931385
Br J Cancer. 2019 Jan;120(1):6-15
pubmed: 30413827
Proc Natl Acad Sci U S A. 2020 Jun 16;117(24):13428-13436
pubmed: 32493746
Nat Commun. 2019 Jul 26;10(1):3345
pubmed: 31350404
Cancers (Basel). 2020 Dec 08;12(12):
pubmed: 33302414
Mol Cell Proteomics. 2012 Apr;11(4):M111.014647
pubmed: 22159717
Front Chem. 2020 Nov 23;8:594619
pubmed: 33330383
BMC Cancer. 2015 Jan 15;15:4
pubmed: 25588705
Nano Lett. 2012 Jun 13;12(6):3213-7
pubmed: 22554317
Sci Rep. 2019 Mar 1;9(1):3299
pubmed: 30824859
Front Mol Biosci. 2020 Jan 31;6:160
pubmed: 32118030
Int J Nanomedicine. 2016 Nov 02;11:5729-5742
pubmed: 27843314
Lancet. 2018 May 26;391(10135):2128-2139
pubmed: 29754777
Biomaterials. 2013 Jan;34(3):746-55
pubmed: 23107297
Science. 2006 Sep 29;313(5795):1960-4
pubmed: 17008531
Nat Rev Immunol. 2009 Apr;9(4):271-85
pubmed: 19319144
Nat Commun. 2019 Nov 8;10(1):5108
pubmed: 31704921
Nano Lett. 2016 May 11;16(5):3268-77
pubmed: 27057591
Adv Mater. 2020 Apr;32(16):e1906745
pubmed: 32105374
Life Sci. 2020 Sep 15;257:118059
pubmed: 32659368
Front Immunol. 2019 Jul 12;10:1563
pubmed: 31354719
Acta Pharm Sin B. 2020 Dec;10(12):2272-2298
pubmed: 33354501
J Control Release. 2019 Apr 28;300:154-160
pubmed: 30844475
J Immunother Cancer. 2020 Mar;8(1):
pubmed: 32169869
Front Oncol. 2018 Mar 12;8:49
pubmed: 29594035
J Control Release. 2020 Sep 10;325:235-248
pubmed: 32649972
Biomaterials. 2016 Apr;85:78-87
pubmed: 26854393
Cancers (Basel). 2020 Dec 13;12(12):
pubmed: 33322132
Blood. 2009 Aug 20;114(8):1537-44
pubmed: 19423728
Nanoscale. 2020 Jan 2;12(2):413-436
pubmed: 31829394
J Control Release. 2014 Oct 28;192:209-18
pubmed: 25068703
Acta Pharmacol Sin. 2020 Jul;41(7):986-994
pubmed: 32317755
Biochemistry. 2020 May 12;59(18):1713-1715
pubmed: 32301606
Int J Nanomedicine. 2018 Oct 09;13:6207-6221
pubmed: 30349245
Cancers (Basel). 2020 Dec 04;12(12):
pubmed: 33291555
Nat Rev Cancer. 2009 Jan;9(1):57-63
pubmed: 19052556
Immunity. 1994 Aug;1(5):405-13
pubmed: 7882171
Nat Rev Cancer. 2004 Oct;4(10):806-13
pubmed: 15510161
Biomolecules. 2019 Feb 12;9(2):
pubmed: 30759891
Nanomedicine. 2018 Feb;14(2):237-246
pubmed: 29127039
Molecules. 2020 Jun 10;25(11):
pubmed: 32532030
Ther Deliv. 2017 Jul;8(8):625-631
pubmed: 28730939
Int J Nanomedicine. 2021 Feb 22;16:1435-1456
pubmed: 33654395
Oncoimmunology. 2020 Jun 2;9(1):1771143
pubmed: 32934877
Adv Sci (Weinh). 2020 Jun 09;7(16):1903323
pubmed: 32832347
Life Sci. 2019 Aug 15;231:116545
pubmed: 31176782
Nat Rev Mol Cell Biol. 2014 Dec;15(12):786-801
pubmed: 25415508
Theranostics. 2018 Jun 6;8(13):3490-3503
pubmed: 30026861
J Exp Med. 2016 Oct 17;213(11):2315-2331
pubmed: 27697834
ACS Nano. 2016 Jun 28;10(6):5823-34
pubmed: 27257911
ISRN Oncol. 2013 Jun 11;2013:371854
pubmed: 23840967
Nat Biotechnol. 2018 Sep;36(8):707-716
pubmed: 29985479
ACS Nano. 2019 Oct 22;13(10):11008-11021
pubmed: 31503443
Sci Adv. 2020 Jul 03;6(27):eaba8564
pubmed: 32923587
Lung Cancer. 2005 Jan;47(1):17-29
pubmed: 15603851
Sci Adv. 2020 Jan 15;6(3):eaax5032
pubmed: 31998834
Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5655-E5663
pubmed: 28652358
ACS Nano. 2019 Nov 26;13(11):12357-12371
pubmed: 31545587
J Natl Cancer Inst. 2015 Nov 17;108(1):
pubmed: 26577528
Biomacromolecules. 2020 Sep 14;21(9):3704-3712
pubmed: 32816460
Cancer Immunol Immunother. 2019 Dec;68(12):2081-2094
pubmed: 31720815
Sci Transl Med. 2014 Mar 19;6(228):228ra37
pubmed: 24648340
J Control Release. 2014 Sep 28;190:451-64
pubmed: 24794900
PLoS One. 2016 Aug 02;11(8):e0160330
pubmed: 27483433
J Hematol Oncol. 2019 Nov 27;12(1):125
pubmed: 31775797
Pharmaceuticals (Basel). 2020 Aug 12;13(8):
pubmed: 32806755
Theranostics. 2021 Jan 1;11(2):906-924
pubmed: 33391512
Adv Drug Deliv Rev. 2003 Feb 24;55(3):403-19
pubmed: 12628324
Nat Commun. 2020 Oct 9;11(1):5120
pubmed: 33037194
Nat Commun. 2018 Aug 23;9(1):3390
pubmed: 30139933
J Control Release. 2019 Nov 10;313:80-95
pubmed: 31622695
Nat Rev Drug Discov. 2019 Mar;18(3):197-218
pubmed: 30610226
Biomater Sci. 2019 Nov 1;7(11):4624-4635
pubmed: 31451819
Front Immunol. 2019 Oct 22;10:2388
pubmed: 31695691
Sci Adv. 2020 Apr 29;6(18):eaaz6579
pubmed: 32494680
Biomaterials. 2019 May;203:23-30
pubmed: 30851490
Nat Nanotechnol. 2016 Nov;11(11):986-994
pubmed: 27668795
Tumour Biol. 2014 Apr;35(4):2871-82
pubmed: 24338768
JCI Insight. 2018 Nov 15;3(22):
pubmed: 30429378
Nat Nanotechnol. 2017 Jul;12(7):648-654
pubmed: 28436963
Mediators Inflamm. 2018 Nov 25;2018:1202797
pubmed: 30595664
Immunotherapy. 2020 Apr;12(5):311-322
pubmed: 32237938
Science. 2015 Apr 3;348(6230):74-80
pubmed: 25838376
Nature. 2016 Sep 22;537(7621):539-543
pubmed: 27626381
Nat Biomed Eng. 2021 May;5(5):455-466
pubmed: 33558734
J Biol Chem. 2016 Apr 22;291(17):8931-50
pubmed: 26719339
Adv Mater. 2019 Dec;31(51):e1904364
pubmed: 31659802
Front Pharmacol. 2018 Aug 06;9:878
pubmed: 30127747
Mol Pharm. 2020 Jun 1;17(6):2109-2124
pubmed: 32383885
J Immunol. 2017 Jul 15;199(2):397-402
pubmed: 28615418
Int J Cell Biol. 2016;2016:9259646
pubmed: 28083070
Biomaterials. 2012 Aug;33(22):5504-13
pubmed: 22579236
Mol Pharm. 2018 Sep 4;15(9):3642-3653
pubmed: 29337566
Adv Ther (Weinh). 2020 Oct;3(10):
pubmed: 34295963
Sci Rep. 2019 Aug 5;9(1):11335
pubmed: 31383907
Carcinogenesis. 2008 Jul;29(7):1334-42
pubmed: 18566014
Curr Top Med Chem. 2014;14(9):1182-93
pubmed: 24678704
Br J Cancer. 2006 Aug 7;95(3):272-81
pubmed: 16832418
APL Bioeng. 2021 Jan 25;5(1):011501
pubmed: 33532673
Nat Biomed Eng. 2018 Aug;2(8):578-588
pubmed: 31015631
Mol Cancer. 2019 Jan 24;18(1):17
pubmed: 30678689
J Control Release. 2019 Jan 10;293:104-112
pubmed: 30476528
ACS Cent Sci. 2020 Jul 22;6(7):1208-1222
pubmed: 32724855
Sci Adv. 2020 Aug 28;6(35):eabc3646
pubmed: 32923651
Breast Cancer Res Treat. 2009 Mar;114(1):47-62
pubmed: 18373191
Cancer Res. 2017 Sep 15;77(18):4763-4772
pubmed: 28536279
Adv Mater. 2019 Aug;31(34):e1803322
pubmed: 30773696
J Control Release. 2012 Feb 28;158(1):148-55
pubmed: 22062689
Biomaterials. 2016 Jun;91:140-150
pubmed: 27019026
Nano Lett. 2017 Feb 8;17(2):862-869
pubmed: 28027646
Nanomicro Lett. 2021 Mar 16;13(1):92
pubmed: 34138315
Nanomedicine (Lond). 2019 Apr;14(8):955-967
pubmed: 30901292