Platelet-Derived Growth Factor-D Activates Complement System to Propagate Macrophage Polarization and Neovascularization.
C1qa
C3
PDGF-D
inflammation
macrophage polarization
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
28
03
2021
accepted:
10
05
2021
entrez:
21
6
2021
pubmed:
22
6
2021
medline:
22
6
2021
Statut:
epublish
Résumé
Platelet-derived growth factor-D (PDGF-D) is highly expressed in immune cells. However, the potential role of PDGF-D in immune system remains thus far unclear. Here, we reveal a novel function of PDGF-D in activating both classical and alternative complement pathways that markedly increase chemokine and cytokine responses to promote macrophage polarization. Pharmacological targeting of the complement C3a receptor using SB290157 alleviated PDGF-D-induced neuroinflammation by blocking macrophage polarization and inhibited pathological choroidal neovascularization. Our study thus suggests that therapeutic strategies targeting both PDGF-D and the complement system may open up new possibilities for the treatment of neovascular diseases.
Identifiants
pubmed: 34150781
doi: 10.3389/fcell.2021.686886
pmc: PMC8207142
doi:
Types de publication
Journal Article
Langues
eng
Pagination
686886Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2021 Xiong, Wang, Li, Huang, Zhang, Zhu, Xie, Wang, Kuang, Lin, Lee, Kumar and Li.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor declared a shared affiliation with the authors at the time of review.
Références
Mol Vis. 1999 Nov 03;5:35
pubmed: 10562659
Cell. 2018 Jan 25;172(3):534-548.e19
pubmed: 29275861
Mol Aspects Med. 2012 Aug;33(4):436-45
pubmed: 22504022
Am J Physiol Renal Physiol. 2019 Nov 1;317(5):F1171-F1182
pubmed: 31461345
Nature. 2008 Jul 24;454(7203):428-35
pubmed: 18650913
Int J Biol Sci. 2020 Sep 23;16(15):2989-3001
pubmed: 33061811
Blood. 2010 Nov 25;116(22):4395-403
pubmed: 20625009
Adv Exp Med Biol. 2010;664:15-9
pubmed: 20237997
Am J Pathol. 1996 Sep;149(3):953-61
pubmed: 8780399
J Exp Med. 1998 Feb 16;187(4):601-8
pubmed: 9463410
Mol Aspects Med. 2018 Aug;62:1-11
pubmed: 29410092
Nat Cell Biol. 2001 May;3(5):512-6
pubmed: 11331881
J Med Chem. 2020 Jan 23;63(2):529-541
pubmed: 31910011
Nephrol Dial Transplant. 2007 May;22(5):1323-31
pubmed: 17308324
Ann Thorac Surg. 2003 Mar;75(3):981-5
pubmed: 12645727
Cell Prolif. 2013 Jun;46(3):328-47
pubmed: 23692091
Invest Ophthalmol Vis Sci. 2014 Mar 25;55(3):1787-96
pubmed: 24458147
Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6152-7
pubmed: 19369214
J Leukoc Biol. 2015 Nov;98(5):713-25
pubmed: 26292978
Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14682-7
pubmed: 12391305
Front Immunol. 2020 Oct 15;11:582825
pubmed: 33178212
J Biol Chem. 2010 May 14;285(20):15500-15510
pubmed: 20231273
J Am Soc Nephrol. 2006 Apr;17(4):1054-62
pubmed: 16510766
Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2328-33
pubmed: 16452172
Oncogene. 2003 Mar 13;22(10):1501-10
pubmed: 12629513
J Immunol. 2001 May 15;166(10):6341-8
pubmed: 11342658
Am J Pathol. 2014 Nov;184(11):3142-53
pubmed: 25204844
Drug Des Devel Ther. 2019 Jul 19;13:2413-2425
pubmed: 31409975
Adv Exp Med Biol. 2008;613:121-8
pubmed: 18188936
Prog Retin Eye Res. 2001 Jan;20(1):29-48
pubmed: 11070367
J Immunol. 1998 Oct 15;161(8):4388-95
pubmed: 9780217
J Pharmacol Sci. 2010;112(1):56-63
pubmed: 20051658
Hum Mol Genet. 2017 Oct 1;26(R2):R246
pubmed: 28977452
Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5722-32
pubmed: 18055825
J Exp Med. 2013 Oct 21;210(11):2477-91
pubmed: 24101381
Mol Aspects Med. 2018 Aug;62:33-43
pubmed: 29079201
Arthritis Rheum. 2006 Mar;54(3):788-94
pubmed: 16508943
Prog Retin Eye Res. 2019 May;70:85-98
pubmed: 30552975
Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4620-30
pubmed: 18450597
Nature. 2011 Jun 08;475(7355):222-5
pubmed: 21654748
FASEB J. 2013 Feb;27(2):822-31
pubmed: 23118029
PLoS One. 2009 Nov 20;4(11):e7945
pubmed: 19936204
Blood. 2004 Nov 15;104(10):3198-204
pubmed: 15271796
Prog Retin Eye Res. 2020 Dec 13;:100936
pubmed: 33321207
Trends Neurosci. 2020 Jun;43(6):433-449
pubmed: 32459994
Gene Ther. 2012 Feb;19(2):162-8
pubmed: 21993172
Diabetes. 2018 Aug;67(8):1549-1560
pubmed: 29794241
Atherosclerosis. 2009 Feb;202(2):415-23
pubmed: 18573494
Exp Neurol. 2016 Sep;283(Pt A):157-64
pubmed: 27302678
Inflamm Res. 2014 Oct;63(10):885-93
pubmed: 25091012
Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12216-21
pubmed: 20566880
Immunol Rev. 2014 Nov;262(1):36-55
pubmed: 25319326
Gene. 2017 May 30;614:1-7
pubmed: 28267575
Immunity. 2017 Feb 21;46(2):261-272
pubmed: 28228282
Br J Ophthalmol. 2011 Dec;95(12):1631-7
pubmed: 21546514
Front Immunol. 2014 Aug 21;5:402
pubmed: 25191325