The gastrointestinal tract in hunger and satiety signalling.
CCK
GLP-1
gastric accommodation
hunger
migrating motor complex
motilin
satiety
Journal
United European gastroenterology journal
ISSN: 2050-6414
Titre abrégé: United European Gastroenterol J
Pays: England
ID NLM: 101606807
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
06
11
2020
accepted:
18
02
2021
pubmed:
22
6
2021
medline:
28
1
2022
entrez:
21
6
2021
Statut:
ppublish
Résumé
Different peripheral pathways are implicated in the regulation of the food ingestion-digestion cycle. Narrative review on gastrointestinal mechanisms involved in satiety and hunger signalling. Combined mechano- and chemoreceptors, peripherally released peptide hormones and neural pathways provide feedback to the brain to determine sensations of hunger (increase energy intake) or satiation (cessation of energy intake) and regulate the human metabolism. The gastric accommodation reflex, which consists of a transient relaxation of the proximal stomach during food intake, has been identified as a major determinant of meal volume, through activation of tension-sensitive gastric mechanoreceptors. Motilin, whose release is the trigger of gastric Phase 3, has been identified as the major determinant of return of hunger after a meal. In addition, the release of several peptide hormones such as glucagon-like peptide 1 (GLP-1), cholecystokinin as well as motilin and ghrelin contributes to gut-brain signalling with relevance to control of hunger and satiety. A number of nutrients, such as bitter tastants, as well as pharmacological agents, such as endocannabinoid receptor antagonists and GLP-1 analogues act on these pathways to influence hunger, satiation and food intake. Gastrointestinal mechanisms such as gastric accommodation and motilin release are key determinants of satiety and hunger.
Sections du résumé
BACKGROUND
Different peripheral pathways are implicated in the regulation of the food ingestion-digestion cycle.
METHODS
Narrative review on gastrointestinal mechanisms involved in satiety and hunger signalling.
RESULTS
Combined mechano- and chemoreceptors, peripherally released peptide hormones and neural pathways provide feedback to the brain to determine sensations of hunger (increase energy intake) or satiation (cessation of energy intake) and regulate the human metabolism. The gastric accommodation reflex, which consists of a transient relaxation of the proximal stomach during food intake, has been identified as a major determinant of meal volume, through activation of tension-sensitive gastric mechanoreceptors. Motilin, whose release is the trigger of gastric Phase 3, has been identified as the major determinant of return of hunger after a meal. In addition, the release of several peptide hormones such as glucagon-like peptide 1 (GLP-1), cholecystokinin as well as motilin and ghrelin contributes to gut-brain signalling with relevance to control of hunger and satiety. A number of nutrients, such as bitter tastants, as well as pharmacological agents, such as endocannabinoid receptor antagonists and GLP-1 analogues act on these pathways to influence hunger, satiation and food intake.
CONCLUSION
Gastrointestinal mechanisms such as gastric accommodation and motilin release are key determinants of satiety and hunger.
Identifiants
pubmed: 34153172
doi: 10.1002/ueg2.12097
pmc: PMC8280794
doi:
Substances chimiques
Ghrelin
0
Motilin
52906-92-0
Glucagon-Like Peptide 1
89750-14-1
Cholecystokinin
9011-97-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
727-734Informations de copyright
© 2021 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC. on behalf of United European Gastroenterology.
Références
United European Gastroenterol J. 2021 Jul;9(6):727-734
pubmed: 34153172
Neurogastroenterol Motil. 2020 Dec;32(12):e13944
pubmed: 32666613
Regul Pept. 1983 Aug;6(4):363-9
pubmed: 6635258
Neurogastroenterol Motil. 2015 Jan;27(1):63-71
pubmed: 25393165
Am J Physiol Gastrointest Liver Physiol. 2007 May;292(5):G1359-65
pubmed: 17290009
Physiol Behav. 1990 Jun;47(6):1213-9
pubmed: 2395927
J Clin Endocrinol Metab. 2018 Feb 1;103(2):575-585
pubmed: 29177486
Neurogastroenterol Motil. 2012 Feb;24(2):108-12, e81
pubmed: 22103293
Am J Clin Nutr. 2016 Mar;103(3):730-7
pubmed: 26817505
Neurogastroenterol Motil. 2008 Jun;20(6):649-59
pubmed: 18298441
Am J Clin Nutr. 2017 Mar;105(3):580-588
pubmed: 28148502
Gastroenterology. 1991 Aug;101(2):503-11
pubmed: 2065926
Sci Rep. 2018 Jan 29;8(1):1819
pubmed: 29379095
Am J Physiol Gastrointest Liver Physiol. 2014 Jul 1;307(1):G122-8
pubmed: 24742985
Am J Physiol Gastrointest Liver Physiol. 2013 Jun 15;304(12):G1117-27
pubmed: 23599045
Nat Rev Gastroenterol Hepatol. 2012 Mar 27;9(5):271-85
pubmed: 22450306
Gastroenterology. 1980 Oct;79(4):716-9
pubmed: 7409389
J Vet Sci. 2014 Dec;15(4):459-64
pubmed: 24962407
Neurogastroenterol Motil. 2012 Jul;24(7):612-5, e267-8
pubmed: 22519421
Neurogastroenterol Motil. 2019 Nov;31(11):e13697
pubmed: 31448521
Gut. 2006 Mar;55(3):327-33
pubmed: 16216827
J Neurosci. 2020 Sep 9;40(37):7054-7064
pubmed: 32817248
Am J Gastroenterol. 2013 May;108(5):698-706
pubmed: 23458851
Int J Obes (Lond). 2013 May;37(5):693-8
pubmed: 22846777
Am J Physiol Gastrointest Liver Physiol. 2012 Apr;302(7):G732-9
pubmed: 22268097
Am J Physiol. 1987 Aug;253(2 Pt 1):G165-70
pubmed: 2887117
Aliment Pharmacol Ther. 2011 Mar;33(5):607-14
pubmed: 21198709
Gastroenterology. 1979 Jul;77(1):115-20
pubmed: 447006
Neurogastroenterol Motil. 2019 Apr;31(4):e13546
pubmed: 30740834
Aliment Pharmacol Ther. 2019 Apr;49(8):997-1004
pubmed: 30828846
Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2094-9
pubmed: 21245306
Gut. 2003 Sep;52(9):1271-7
pubmed: 12912857
Neurogastroenterol Motil. 2011 Apr;23(4):316-22, e153-4
pubmed: 21299720
Neurogastroenterol Motil. 2018 Jan;30(1):
pubmed: 28776826
Physiol Behav. 1994 Dec;56(6):1165-71
pubmed: 7878086
Gut. 1999 Jan;44(1):81-6
pubmed: 9862830
Gut. 2001 Mar;48(3):347-55
pubmed: 11171824
Am J Physiol. 1997 Sep;273(3 Pt 1):G721-6
pubmed: 9316477
Neurogastroenterol Motil. 2018 Jan;30(1):
pubmed: 28762592
Neurogastroenterol Motil. 2003 Oct;15(5):447-55
pubmed: 14507346
J Mol Endocrinol. 2010 Jan;44(1):37-44
pubmed: 19696113
Gut. 2001 Aug;49(2):203-8
pubmed: 11454795
Gastroenterology. 1998 Dec;115(6):1346-52
pubmed: 9834261
Aliment Pharmacol Ther. 2010 May;31(10):1123-31
pubmed: 20146701
Am J Physiol. 1972 Feb;222(2):428-31
pubmed: 5058385
Aliment Pharmacol Ther. 2011 Apr;33(8):880-94
pubmed: 21342212
Gut. 2016 Jul;65(7):1110-8
pubmed: 25986945
Nutrients. 2020 May 27;12(6):
pubmed: 32471227
Nutr Neurosci. 2019 Dec;22(12):850-862
pubmed: 29607741
Nat Rev Gastroenterol Hepatol. 2013 Dec;10(12):729-40
pubmed: 24061204
Gut. 2002 Mar;50(3):341-8
pubmed: 11839712
Gut. 2016 Feb;65(2):214-24
pubmed: 25539673
Am J Physiol Gastrointest Liver Physiol. 2002 Mar;282(3):G424-31
pubmed: 11841992