A new classification of cardio-oncology syndromes.
Cancer
Cardiac Tumours
Cardio-oncology
Cardiotoxicity
Cardiovascular disease
Heart failure
Immune system
Inflammation
Medical diagnostic radiation
Prevention
Prognostic biomarkers
Journal
Cardio-oncology (London, England)
ISSN: 2057-3804
Titre abrégé: Cardiooncology
Pays: England
ID NLM: 101689938
Informations de publication
Date de publication:
21 Jun 2021
21 Jun 2021
Historique:
received:
11
02
2021
accepted:
30
05
2021
entrez:
22
6
2021
pubmed:
23
6
2021
medline:
23
6
2021
Statut:
epublish
Résumé
Increasing evidence suggests a multifaceted relationship exists between cancer and cardiovascular disease (CVD). Here, we introduce a 5-tier classification system to categorize cardio-oncology syndromes (COS) that represent the aspects of the relationship between cancer and CVD. COS Type I is characterized by mechanisms whereby the abrupt onset or progression of cancer can lead to cardiovascular dysfunction. COS Type II includes the mechanisms by which cancer therapies can result in acute or chronic CVD. COS Type III is characterized by the pro-oncogenic environment created by the release of cardiokines and high oxidative stress in patients with cardiovascular dysfunction. COS Type IV is comprised of CVD therapies and diagnostic procedures which have been associated with promoting or unmasking cancer. COS Type V is characterized by factors causing systemic and genetic predisposition to both CVD and cancer. The development of this framework may allow for an increased facilitation of cancer care while optimizing cardiovascular health through focused treatment targeting the COS type.
Identifiants
pubmed: 34154667
doi: 10.1186/s40959-021-00110-1
pii: 10.1186/s40959-021-00110-1
pmc: PMC8218489
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
24Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : H2020 European Research Council
ID : 818715
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