Hetero-Bis-Conjugation of Bioactive Molecules to Half-Sandwich Ruthenium(II) and Iridium(III) Complexes Provides Synergic Effects in Cancer Cell Cytotoxicity.
Antineoplastic Agents
/ chemical synthesis
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Coordination Complexes
/ chemical synthesis
DNA Damage
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Iridium
/ chemistry
Ligands
Molecular Structure
Pyridines
/ chemistry
Ruthenium
/ chemistry
Tumor Cells, Cultured
Journal
Inorganic chemistry
ISSN: 1520-510X
Titre abrégé: Inorg Chem
Pays: United States
ID NLM: 0366543
Informations de publication
Date de publication:
05 Jul 2021
05 Jul 2021
Historique:
pubmed:
23
6
2021
medline:
14
7
2021
entrez:
22
6
2021
Statut:
ppublish
Résumé
Four bipyridine-type ligands variably derivatized with two bioactive groups (taken from ethacrynic acid, flurbiprofen, biotin, and benzylpenicillin) were prepared via sequential esterification steps from commercial 2,2'-bipyridine-4,4'-dicarboxylic acid and subsequently coordinated to ruthenium(II)
Identifiants
pubmed: 34156246
doi: 10.1021/acs.inorgchem.1c00641
doi:
Substances chimiques
Antineoplastic Agents
0
Coordination Complexes
0
Ligands
0
Pyridines
0
Iridium
44448S9773
Ruthenium
7UI0TKC3U5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM