Estrogen receptor-α signaling in post-natal mammary development and breast cancers.
17β-estradiol
ERα-positive luminal cells
Lineage specification
Mammary gland
Stem cells
Journal
Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
25
01
2021
accepted:
19
05
2021
revised:
12
05
2021
pubmed:
23
6
2021
medline:
3
8
2021
entrez:
22
6
2021
Statut:
ppublish
Résumé
17β-estradiol controls post-natal mammary gland development and exerts its effects through Estrogen Receptor ERα, a member of the nuclear receptor family. ERα is also critical for breast cancer progression and remains a central therapeutic target for hormone-dependent breast cancers. In this review, we summarize the current understanding of the complex ERα signaling pathways that involve either classical nuclear "genomic" or membrane "non-genomic" actions and regulate in concert with other hormones the different stages of mammary development. We describe the cellular and molecular features of the luminal cell lineage expressing ERα and provide an overview of the transgenic mouse models impacting ERα signaling, highlighting the pivotal role of ERα in mammary gland morphogenesis and function and its implication in the tumorigenic processes. Finally, we describe the main features of the ERα-positive luminal breast cancers and their modeling in mice.
Identifiants
pubmed: 34156490
doi: 10.1007/s00018-021-03860-4
pii: 10.1007/s00018-021-03860-4
pmc: PMC8316234
doi:
Substances chimiques
Estrogen Receptor alpha
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
5681-5705Informations de copyright
© 2021. The Author(s).
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