A double-blind randomized controlled trial combining cognitive training (CoRe) and neurostimulation (tDCS) in the early stages of cognitive impairment.
Cognitive training
Inter-individual variability
Multi-domain intervention
Neurodegenerative diseases
tDCS
Journal
Aging clinical and experimental research
ISSN: 1720-8319
Titre abrégé: Aging Clin Exp Res
Pays: Germany
ID NLM: 101132995
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
05
02
2021
accepted:
10
06
2021
pubmed:
23
6
2021
medline:
1
2
2022
entrez:
22
6
2021
Statut:
ppublish
Résumé
The prevalence of neurodegenerative diseases is expected to increase over the next years, therefore, new methods able to prevent and delay cognitive decline are needed. To evaluate the effectiveness of a combined treatment protocol associating a computerized cognitive training (CoRe) with anodal transcranial direct current stimulation (tDCS). In this randomized controlled trial, 33 patients in the early stage of cognitive impairment were assigned to the experimental group (CoRE + real tDCS) or control group (CoRE + sham tDCS). In each group, the intervention lasted 3 consecutive weeks (4 sessions/week). A neuropsychological assessment was administered at baseline (T0), post-intervention (T1) and 6-months later (T2). The CoRE + real tDCS group only improved in working memory and attention/processing speed at both T1 and T2. It reported a stable MMSE score at T2, while the CoRE + sham tDCS group worsened. Age, mood, and T0 MMSE score resulted to play a role in predicting treatment effects. Combined multi-domain interventions may contribute to preventing or delaying disease progression. Trial registration number (ClinicalTrials.gov): NCT04118686.
Sections du résumé
BACKGROUND
BACKGROUND
The prevalence of neurodegenerative diseases is expected to increase over the next years, therefore, new methods able to prevent and delay cognitive decline are needed.
AIMS
OBJECTIVE
To evaluate the effectiveness of a combined treatment protocol associating a computerized cognitive training (CoRe) with anodal transcranial direct current stimulation (tDCS).
METHODS
METHODS
In this randomized controlled trial, 33 patients in the early stage of cognitive impairment were assigned to the experimental group (CoRE + real tDCS) or control group (CoRE + sham tDCS). In each group, the intervention lasted 3 consecutive weeks (4 sessions/week). A neuropsychological assessment was administered at baseline (T0), post-intervention (T1) and 6-months later (T2).
RESULTS
RESULTS
The CoRE + real tDCS group only improved in working memory and attention/processing speed at both T1 and T2. It reported a stable MMSE score at T2, while the CoRE + sham tDCS group worsened. Age, mood, and T0 MMSE score resulted to play a role in predicting treatment effects.
CONCLUSION
CONCLUSIONS
Combined multi-domain interventions may contribute to preventing or delaying disease progression.
TRIAL REGISTRATION
BACKGROUND
Trial registration number (ClinicalTrials.gov): NCT04118686.
Identifiants
pubmed: 34156651
doi: 10.1007/s40520-021-01912-0
pii: 10.1007/s40520-021-01912-0
doi:
Banques de données
ClinicalTrials.gov
['NCT04118686']
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
73-83Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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