Analysis of exosome-derived microRNAs reveals insights of intercellular communication during invasion of breast, prostate and glioblastoma cancer cells.


Journal

Cell adhesion & migration
ISSN: 1933-6926
Titre abrégé: Cell Adh Migr
Pays: United States
ID NLM: 101469464

Informations de publication

Date de publication:
12 2021
Historique:
entrez: 23 6 2021
pubmed: 24 6 2021
medline: 15 12 2021
Statut: ppublish

Résumé

MiRNAs represent a mechanism that regulates gene expression in many pathological conditions. Exosomes are known to be secreted from all types of cells, and the exosomes-released molecules are crucial messengers that can regulate cellular processes. We investigated the miRNAs content of exosomes released by cancer cells during the invasion . An invasion stimulus has been generated through scratches created on the confluent cells of cancer cell lines: glioblastoma, breast and prostate cancers.Several miRNAs were found to be significantly differentially abundant during the cell invasion , both in common among different cell lines and exclusive. Understanding the language codes among cells involved in invasion can lead to the development of therapies that can inhibit cellular communication, slowing or eventually stopping their activity.

Identifiants

pubmed: 34157951
doi: 10.1080/19336918.2021.1935407
pmc: PMC8224203
doi:

Substances chimiques

MicroRNAs 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

180-201

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Auteurs

Francesca Lessi (F)

Fondazione Pisana per La Scienza, Pisa, Italy.

Paolo Aretini (P)

Fondazione Pisana per La Scienza, Pisa, Italy.

Milena Rizzo (M)

Institute of Clinical Physiology (IFC), CNR, Pisa, Italy.

Mariangela Morelli (M)

Fondazione Pisana per La Scienza, Pisa, Italy.

Michele Menicagli (M)

Fondazione Pisana per La Scienza, Pisa, Italy.

Sara Franceschi (S)

Fondazione Pisana per La Scienza, Pisa, Italy.

Chiara Maria Mazzanti (CM)

Fondazione Pisana per La Scienza, Pisa, Italy.

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Classifications MeSH