SOX11 Inhibitors Are Cytotoxic in Mantle Cell Lymphoma.
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
15 08 2021
15 08 2021
Historique:
received:
07
01
2021
revised:
19
03
2021
accepted:
27
05
2021
pubmed:
24
6
2021
medline:
2
4
2022
entrez:
23
6
2021
Statut:
ppublish
Résumé
Mantle cell lymphoma (MCL) is a fatal subtype of non-Hodgkin lymphoma. SOX11 transcription factor is overexpressed in the majority of nodal MCL. We have previously reported that B cell-specific overexpression of SOX11 promotes MCL pathogenesis via critically increasing BCR signaling Using a combination of We find mechanistic validation of on-target activity of these SOX11i in the inhibition of BCR signaling and the transcriptional modulation of SOX11 target genes, specifically, in SOX11-expressing MCL cells. One of the three SOX11i exhibits relatively superior Taken together, our results provide a foundation for therapeutically targeting SOX11 in MCL by a novel class of small molecules.
Identifiants
pubmed: 34158358
pii: 1078-0432.CCR-20-5039
doi: 10.1158/1078-0432.CCR-20-5039
pmc: PMC8364871
mid: NIHMS1714578
doi:
Substances chimiques
SOX11 protein, human
0
SOXC Transcription Factors
0
Sox11 protein, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4652-4663Subventions
Organisme : NIGMS NIH HHS
ID : T32 GM062754
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA169487
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA244899
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA252222
Pays : United States
Organisme : NIH HHS
ID : S10 OD018522
Pays : United States
Organisme : NIH HHS
ID : S10 OD026880
Pays : United States
Informations de copyright
©2021 American Association for Cancer Research.
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