The ATF6β-calreticulin axis promotes neuronal survival under endoplasmic reticulum stress and excitotoxicity.
Activating Transcription Factor 6
/ metabolism
Animals
Brain
Calreticulin
/ metabolism
Cell Death
/ physiology
Cell Survival
/ physiology
Endoplasmic Reticulum
/ metabolism
Endoplasmic Reticulum Stress
/ physiology
Female
Hippocampus
Homeostasis
Kainic Acid
/ pharmacology
Male
Mice
Mice, Inbred C57BL
Neurons
/ metabolism
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
22 06 2021
22 06 2021
Historique:
received:
01
03
2021
accepted:
09
06
2021
entrez:
23
6
2021
pubmed:
24
6
2021
medline:
9
11
2021
Statut:
epublish
Résumé
While ATF6α plays a central role in the endoplasmic reticulum (ER) stress response, the function of its paralogue ATF6β remains elusive, especially in the central nervous system (CNS). Here, we demonstrate that ATF6β is highly expressed in the hippocampus of the brain, and specifically regulates the expression of calreticulin (CRT), a molecular chaperone in the ER with a high Ca
Identifiants
pubmed: 34158584
doi: 10.1038/s41598-021-92529-w
pii: 10.1038/s41598-021-92529-w
pmc: PMC8219835
doi:
Substances chimiques
Activating Transcription Factor 6
0
Atf6b protein, mouse
0
Calreticulin
0
Kainic Acid
SIV03811UC
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13086Références
J Neural Transm (Vienna). 2014 Oct;121(10):1233-43
pubmed: 24728926
J Cell Biol. 1980 Jun;85(3):890-902
pubmed: 6248568
Dev Cell. 2007 Sep;13(3):365-76
pubmed: 17765680
J Neurosci. 2007 Jan 24;27(4):901-8
pubmed: 17251432
Int J Mol Sci. 2014 Nov 25;15(12):21740-53
pubmed: 25429433
Cell. 2012 Jun 8;149(6):1257-68
pubmed: 22682248
J Neurochem. 2016 Dec;139(6):1124-1137
pubmed: 27333444
J Neuroimmunol. 2003 Feb;135(1-2):62-71
pubmed: 12576225
Front Neurosci. 2019 Jun 19;13:637
pubmed: 31275110
Neuropharmacology. 2015 Oct;97:210-9
pubmed: 26051398
Nat Commun. 2014 Jun 13;5:4153
pubmed: 24923787
Exp Cell Res. 2000 Apr 10;256(1):105-11
pubmed: 10739657
Neurochem Int. 2016 Jan;92:67-74
pubmed: 26724566
Biochemistry. 2008 Mar 25;47(12):3697-704
pubmed: 18303859
Int J Biochem Cell Biol. 2012 Jun;44(6):842-6
pubmed: 22373697
Nat Protoc. 2006;1(5):2406-15
pubmed: 17406484
Nucleic Acids Res. 2019 Jan 8;47(D1):D745-D751
pubmed: 30407521
Nat Biotechnol. 2013 Jan;31(1):46-53
pubmed: 23222703
Mol Cell Biol. 2000 Sep;20(18):6755-67
pubmed: 10958673
Acta Neuropathol. 2000 Aug;100(2):153-60
pubmed: 10963362
Sci Rep. 2019 Feb 14;9(1):2059
pubmed: 30765833
J Clin Invest. 2001 Nov;108(10):1439-50
pubmed: 11714735
Cell Calcium. 2003 Feb;33(2):83-9
pubmed: 12531184
J Cell Biol. 1999 Mar 8;144(5):857-68
pubmed: 10085286
PLoS One. 2012;7(10):e47950
pubmed: 23112876
J Neurochem. 2015 Feb;132(3):342-53
pubmed: 25351847
Cell. 2006 May 5;125(3):443-51
pubmed: 16678092
J Clin Invest. 2001 May;107(10):1245-53
pubmed: 11375414
Biochem J. 2001 Apr 1;355(Pt 1):19-28
pubmed: 11256944
J Cell Biol. 1997 Aug 11;138(3):547-57
pubmed: 9245785
Mol Neurodegener. 2017 May 25;12(1):42
pubmed: 28545479
Mol Biol Cell. 2013 May;24(9):1387-95
pubmed: 23447699
PLoS One. 2017 Jan 10;12(1):e0169861
pubmed: 28072885
Neurobiol Dis. 2015 Jan;73:130-6
pubmed: 25277755
Nature. 2013 Jul 18;499(7458):295-300
pubmed: 23868258
Sci Rep. 2015 Sep 21;5:14254
pubmed: 26388295
Biochem J. 2009 Feb 1;417(3):651-66
pubmed: 19133842
Science. 2011 Nov 25;334(6059):1081-6
pubmed: 22116877
PLoS One. 2014 Feb 07;9(2):e88506
pubmed: 24516667
J Biochem. 2009 Dec;146(6):743-50
pubmed: 19861400
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
J Biol Chem. 1998 Dec 11;273(50):33741-9
pubmed: 9837962
J Neurosci. 2012 Apr 4;32(14):4901-12
pubmed: 22492046