Multi drug resistant tuberculosis
Mycobacterium tuberculosis complex
Nontuberculous mycobacteria
Journal
Ethiopian journal of health sciences
ISSN: 2413-7170
Titre abrégé: Ethiop J Health Sci
Pays: Ethiopia
ID NLM: 101224773
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
entrez:
23
6
2021
pubmed:
24
6
2021
medline:
19
8
2021
Statut:
ppublish
Résumé
Mycobacterial infections are known to cause a public health problem globally. The burden of pulmonary disease from nontuberculous mycobacteria is reportedly on the rise in different parts of the world despite the fact that there is limited data about the disease in sub-Saharan Africa including Ethiopia. Hence, we aimed to assess the magnitude of M. tuberculosis and nontuberculous mycobacteria (NTM) among presumptive pulmonary tuberculosis patients attending St. Paul's hospital Medical College, Addis Ababa, Ethiopia. A cross-sectional study was conducted from June to September 20/2016. Morning sputum specimens were collected, processed and cultured in Lowenstein Jensen medium and BACTEC MGIT 960 media. The nontuberculous mycobacteria were further confirmed and characterized by Genotype CM/AS assays. The socio-demographic, clinical and chest x-ray data were collected using a structured questionnaire. The data was analyzed using SPSS version 20. Out of 275 presumptive tuberculosis patients enrolled in the study, 29(10.5%) were culture positive for Mycobacteria. Of these, 3(10.3%) were found to be NTM and 26(89.6%) were Mycobacterium tuberculosis complex. Of the NTM, two were unidentified and one typed as M.peregrinum. There was no co-isolation of Mycobacterium tuberculosis complex and nontuberculous mycobacteria. Overall, 6(23.1%) Mycobacterium tuberculosis complex isolates were resistant to at least one anti-tuberculosis drug. Of these, two were multidrug resistant tuberculosis cases (7.7%) detected from previously treated patients. Relatively low magnitude of Mycobacterium tuberculosis complex and nontuberculous mycobacteria isolates were seen in the study area. Therefore, further study using a large sample size is needed to be done to consider nontuberculous mycobacteria infection as a differential diagnosis in presumptive pulmonary tuberculosis patients.
Sections du résumé
BACKGROUND
BACKGROUND
Mycobacterial infections are known to cause a public health problem globally. The burden of pulmonary disease from nontuberculous mycobacteria is reportedly on the rise in different parts of the world despite the fact that there is limited data about the disease in sub-Saharan Africa including Ethiopia. Hence, we aimed to assess the magnitude of M. tuberculosis and nontuberculous mycobacteria (NTM) among presumptive pulmonary tuberculosis patients attending St. Paul's hospital Medical College, Addis Ababa, Ethiopia.
METHODS
METHODS
A cross-sectional study was conducted from June to September 20/2016. Morning sputum specimens were collected, processed and cultured in Lowenstein Jensen medium and BACTEC MGIT 960 media. The nontuberculous mycobacteria were further confirmed and characterized by Genotype CM/AS assays. The socio-demographic, clinical and chest x-ray data were collected using a structured questionnaire. The data was analyzed using SPSS version 20.
RESULTS
RESULTS
Out of 275 presumptive tuberculosis patients enrolled in the study, 29(10.5%) were culture positive for Mycobacteria. Of these, 3(10.3%) were found to be NTM and 26(89.6%) were Mycobacterium tuberculosis complex. Of the NTM, two were unidentified and one typed as M.peregrinum. There was no co-isolation of Mycobacterium tuberculosis complex and nontuberculous mycobacteria. Overall, 6(23.1%) Mycobacterium tuberculosis complex isolates were resistant to at least one anti-tuberculosis drug. Of these, two were multidrug resistant tuberculosis cases (7.7%) detected from previously treated patients.
CONCLUSION
CONCLUSIONS
Relatively low magnitude of Mycobacterium tuberculosis complex and nontuberculous mycobacteria isolates were seen in the study area. Therefore, further study using a large sample size is needed to be done to consider nontuberculous mycobacteria infection as a differential diagnosis in presumptive pulmonary tuberculosis patients.
Identifiants
pubmed: 34158748
doi: 10.4314/ejhs.v31i1.3
pii: jEJHS.v31.i1.pg15
pmc: PMC8188102
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
15-24Subventions
Organisme : FIC NIH HHS
ID : D43 TW009127
Pays : United States
Informations de copyright
© 2021 Daniel Kahase, et al.
Références
Int J Mycobacteriol. 2019 Jan-Mar;8(1):1-6
pubmed: 30860172
Int J Tuberc Lung Dis. 2010 May;14(5):654-6
pubmed: 20392362
Pulm Med. 2014;2014:894976
pubmed: 25132991
PLoS One. 2013 May 09;8(5):e63170
pubmed: 23671669
Trop Med Int Health. 2016 Sep;21(9):1181-90
pubmed: 27383726
Nihon Kokyuki Gakkai Zasshi. 2010 Nov;48(11):866-70
pubmed: 21141068
PLoS One. 2015 Jun 08;10(6):e0129073
pubmed: 26052701
Semin Respir Crit Care Med. 2013 Feb;34(1):87-94
pubmed: 23460008
J Infect Dev Ctries. 2012 Jan 12;6(1):33-9
pubmed: 22240426
BMC Res Notes. 2016 Feb 17;9:109
pubmed: 26887928
Int J Tuberc Lung Dis. 2013 May;17(5):676-81
pubmed: 23575335
BMC Infect Dis. 2013 Feb 18;13:88
pubmed: 23413873
Emerg Infect Dis. 2011 Mar;17(3):506-9
pubmed: 21392445
BMC Public Health. 2015 Jun 20;15:572
pubmed: 26092570
Int J Tuberc Lung Dis. 2004 Nov;8(11):1388-91
pubmed: 15581212
Afr Health Sci. 2012 Sep;12(3):305-11
pubmed: 23382744
Biomed Res Int. 2014;2014:919474
pubmed: 25574470
PLoS One. 2011 Apr 19;6(4):e18614
pubmed: 21526179
Asian Pac J Trop Med. 2015 Jan;8(1):35-40
pubmed: 25901922
Ann Am Thorac Soc. 2014 Jan;11(1):117-21
pubmed: 24460445
Tuberc Res Treat. 2012;2012:301056
pubmed: 22919477
J Clin Microbiol. 2003 Nov;41(11):5121-6
pubmed: 14605148
Ethiop Med J. 2009 Jan;47(1):17-24
pubmed: 19743776