Proteomic differences in the hippocampus and cortex of epilepsy brain tissue.
epilepsy
proteomics
seizures
synaptophysin
Journal
Brain communications
ISSN: 2632-1297
Titre abrégé: Brain Commun
Pays: England
ID NLM: 101755125
Informations de publication
Date de publication:
2021
2021
Historique:
received:
09
09
2020
revised:
10
12
2020
accepted:
11
12
2020
entrez:
23
6
2021
pubmed:
24
6
2021
medline:
24
6
2021
Statut:
epublish
Résumé
Epilepsy is a common neurological disorder affecting over 70 million people worldwide, with a high rate of pharmaco-resistance, diverse comorbidities including progressive cognitive and behavioural disorders, and increased mortality from direct (e.g. sudden unexpected death in epilepsy, accidents, drowning) or indirect effects of seizures and therapies. Extensive research with animal models and human studies provides limited insights into the mechanisms underlying seizures and epileptogenesis, and these have not translated into significant reductions in pharmaco-resistance, morbidities or mortality. To help define changes in molecular signalling networks associated with seizures in epilepsy with a broad range of aetiologies, we examined the proteome of brain samples from epilepsy and control cases. Label-free quantitative mass spectrometry was performed on the hippocampal cornu ammonis 1-3 region (CA1-3), frontal cortex and dentate gyrus microdissected from epilepsy and control cases (
Identifiants
pubmed: 34159317
doi: 10.1093/braincomms/fcab021
pii: fcab021
pmc: PMC8214864
doi:
Types de publication
Journal Article
Langues
eng
Pagination
fcab021Subventions
Organisme : NIA NIH HHS
ID : P01 AG060882
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066512
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG058267
Pays : United States
Organisme : NIH HHS
ID : S10 OD010582
Pays : United States
Informations de copyright
Published by Oxford University Press on behalf of the Guarantors of Brain 2021. This work is written by (a) US Government employee(s) and is in the public domain in the US.
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