Predictors and Complications of Post Kidney Transplant Leukopenia.
cytomegalovirus
immunotherapy
kidney transplantation
post-kidney transplant complications
post-transplant leukopenia
Journal
Progress in transplantation (Aliso Viejo, Calif.)
ISSN: 2164-6708
Titre abrégé: Prog Transplant
Pays: United States
ID NLM: 100909380
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
pubmed:
24
6
2021
medline:
29
10
2021
entrez:
23
6
2021
Statut:
ppublish
Résumé
Leukopenia occurs frequently following kidney transplantation and is associated with adverse clinical outcomes including increased infectious risk. In this study we sought to characterize the causes and complications of leukopenia following kidney transplantation. In a cohort of adult patients (≥18 years) who underwent kidney transplant from Jan 2006-Dec 2017, we used univariable Cox proportional Hazards models to identify predictors of post-transplant leukopenia (WBC < 3500 mm Of 388 recipients, 152 (39%) developed posttransplant leukopenia. Factors associated with leukopenia included antithymocyte globulin as induction therapy (HR 3.32, 95% CI 2.25-4.91), valganciclovir (HR 1.84, 95% CI 1.25-2.70), tacrolimus (HR 3.05, 95% CI 1.08-8.55), prior blood transfusion (HR 1.17 per unit, 95% CI 1.09- 1.25), and donor age (HR 1.02 per year, 95% CI 1.00-1.03). Cytomegalovirus infection occurred in 26 patients with leukopenia (17.1%). Other than cytomegalovirus, leukopenia was not associated with posttransplant complications. Leukopenia commonly occurred posttransplant and was associated with modifiable and non-modifiable pretransplant factors.
Sections du résumé
BACKGROUND
Leukopenia occurs frequently following kidney transplantation and is associated with adverse clinical outcomes including increased infectious risk. In this study we sought to characterize the causes and complications of leukopenia following kidney transplantation.
METHODS
In a cohort of adult patients (≥18 years) who underwent kidney transplant from Jan 2006-Dec 2017, we used univariable Cox proportional Hazards models to identify predictors of post-transplant leukopenia (WBC < 3500 mm
RESULTS
Of 388 recipients, 152 (39%) developed posttransplant leukopenia. Factors associated with leukopenia included antithymocyte globulin as induction therapy (HR 3.32, 95% CI 2.25-4.91), valganciclovir (HR 1.84, 95% CI 1.25-2.70), tacrolimus (HR 3.05, 95% CI 1.08-8.55), prior blood transfusion (HR 1.17 per unit, 95% CI 1.09- 1.25), and donor age (HR 1.02 per year, 95% CI 1.00-1.03). Cytomegalovirus infection occurred in 26 patients with leukopenia (17.1%). Other than cytomegalovirus, leukopenia was not associated with posttransplant complications.
CONCLUSION
Leukopenia commonly occurred posttransplant and was associated with modifiable and non-modifiable pretransplant factors.
Identifiants
pubmed: 34159855
doi: 10.1177/15269248211024614
doi:
Substances chimiques
Antilymphocyte Serum
0
Valganciclovir
GCU97FKN3R
Types de publication
Journal Article
Langues
eng